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Carmustine slow-release tablet and its preparation method

A slow-release film and a slow-release film technology are applied in the field of carbazide slow-release film and its preparation, which can solve the problems of inability to specifically act on tumor sites, large toxic reactions, etc., to avoid peaks and troughs, reduce painful effect

Inactive Publication Date: 2004-09-01
天津市第一中心医院 +1
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Problems solved by technology

[0004] Carmustine (BCNU), which is commercially available for intravenous administration, is currently a commonly used anti-tumor chemotherapy drug in clinical practice. It spreads through the blood-brain barrier and reaches the whole body, but cannot specifically act on the tumor site, and has a relatively high toxicity.

Method used

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  • Carmustine slow-release tablet and its preparation method
  • Carmustine slow-release tablet and its preparation method

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Embodiment Construction

[0033] Polylactic acid-chloroform (CHCL 3 ) solution: first mix 0.05kg of 20,000 molecular weight L-polylactic acid and 70,000 molecular weight L-polylactic acid into solid polylactic acid powder; put 0.1kg of solid polylactic acid powder into a round bottom flask, add chloroform Solution 0.9kg, put the flask in a matching electric heating mantle, install a condensing device at the mouth of the bottle, turn on the power (connected to an adjustable transformer), heat slowly, adjust the voltage when boiling to keep it slightly boiling for 1 hour, and then disconnect the power Turn off heat.

[0034] When the temperature of the solution drops to room temperature, add 0.01 kg of carmustine and shake gently to completely dissolve the carmustine.

[0035] Casting film: In the ultra-clean bench, pour the polylactic acid-carmustine-chloroform solution prepared above into several polyethylene molds to make a film containing 10% carmustine with a diameter of about 13-15mm , a diaphrag...

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Abstract

The invention relates to a carmustine slow release diaphragm and method for making same, which is a medical arrangement characterized by macromolecular compound carrying agent or antitumor agent, wherein carmustine and degradable high molecular polymer are used to form films to be implanted into tumor position through operation, the polymer is degraded, thus the medicament releases slowly at a finite speed to achieving the goal of localized treatment.

Description

technical field [0001] The invention relates to a medical preparation or an antineoplastic drug characterized by a macromolecular compound carrier, in particular to a carmustine slow-release membrane and a preparation method thereof. Background technique [0002] Half of primary brain tumors are gliomas, and most (77%) malignant gliomas die within 1 year of diagnosis. The main reason why glioma is difficult to cure is that it is easy to relapse. Because of its infiltrative growth and unclear boundary with normal brain tissue, it is impossible to completely remove it by surgery. For malignant glioma treated with surgery alone, the average survival period is only 6 months, but with radiotherapy after surgery, the average survival period is no more than one year. In the past 10 years, important progress has been made in chemotherapy, but it is difficult for chemotherapy drugs to penetrate the blood-brain barrier through conventional intravenous administration. lead to increas...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/17A61K47/34A61P35/00
Inventor 王金环鲁格徐新女苏同芳李牧祁建滨刘宏胜张又平刘萍
Owner 天津市第一中心医院
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