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Indometacin eyedrops

A technology of indomethacin and eye drops, applied in sensory diseases, anti-infective drugs, drug combinations, etc., can solve problems such as retention, systemic side effects, and less obvious curative effects, and achieve inhibition of cyclooxygenase activity and release Inflammatory effect, the effect of simple production method

Inactive Publication Date: 2004-08-04
赵珊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, although there are many drugs used to treat eye injuries such as uveitis, conjunctivitis, and keratitis and inflammation caused by eye surgery in ophthalmology, their curative effects are not obvious. Commonly used drugs such as cortisone acetate eye drops liquid, dexamethasone eye drops, etc., but because some eye drops belong to hormone drugs and have effects contrary to clinical treatment, the scope of application is not wide enough
Domestic clinical use of indomethacin preparations mostly stays in traditional oral administration, often causing systemic side effects, which is the deficiency of existing drugs for the treatment of eye diseases

Method used

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Examples

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Embodiment Construction

[0007] Examples of the parts by weight of raw materials included in the present invention are: 40 indomethacin, polyethylene glycol-4003200, 8 sodium sulfite, 48 borax, 176 boric acid, and 8000 water for injection.

[0008] The molecular formula of indomethacin of the present invention is: C 19 h 16 CINO 4

[0009] The shape of the present invention is light yellow clear liquid with a pH value of 6.5-8.5.

[0010] The production method of the embodiment of the present invention is: A. Weighing: use a specified scale or balance to accurately weigh indomethacin, sodium sulfite, borax, and boric acid as the above-mentioned parts by weight, and store them in clean containers for subsequent use; B. : Take 8000 parts of heavy water for injection and put it in a clean batching tank (1), add 8 parts by weight of sodium sulfite, 48 parts of borax, and 176 parts of boric acid successively under the condition of stirring, fully dissolve, airtight, boil and sterilize in 100 ℃ water for...

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Abstract

An indometacin eyedrops for treating ophthalmopathy including the non-infective inflammation caused by operating is prepared from indometacin, polyethanediol-400, sodium sulfite, borax, boric acid and the water for injection.

Description

1. Technical field [0001] The invention relates to a medicine for treating eye diseases, in particular to an indomethacin eye drop. 2. Background technology [0002] At present, although there are many drugs used to treat eye injuries such as uveitis, conjunctivitis, and keratitis and inflammation caused by eye surgery in ophthalmology, their curative effects are not obvious. Commonly used drugs such as cortisone acetate eye drops Liquid, dexamethasone eye drops, etc., but because some of the eye drops belong to hormone drugs, which have the effect contrary to clinical treatment, so the scope of application is not wide enough. Domestic clinical use of indomethacin preparations mostly stays in the traditional oral administration, which often causes systemic side effects, which is the deficiency of the existing drugs for treating eye diseases. 3. Contents of the invention [0003] The purpose of the present invention is to invent a kind of indomethacin eye drop, this eye dr...

Claims

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Application Information

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IPC IPC(8): A61K31/405A61P27/02A61P31/00
Inventor 赵珊
Owner 赵珊
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