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Gelatin-blood plasma and its preparing method

A technology for replacing plasma and gelatin, which is applied in the field of replacing plasma with gelatin and its preparation to achieve the effect of maintaining normal urine volume and increasing or restoring blood volume

Inactive Publication Date: 2003-11-26
刘威
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The plasma substitute prepared by applying gelatin in medicine is called gelatin substitute plasma, and the preparation method of relevant gelatin substitute plasma is as described in CN1036397A and CN1037084A, and these comparative documents all use marine echinoderm-starfish as raw materials to prepare gelatin substitute plasma. There are no related reports on the preparation of gelatin substitute plasma from seal skin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1. Pretreatment of seal raw materials:

[0040] Newly hunted fur seals are slaughtered and skinned, subcutaneous fat removed, hair and epidermis scraped off, frozen at -80°C, thawed naturally with flowing water before use, cut into small pieces of 5×5cm, and used at 2°C Soak in 0.3% (w / v) NaOH solution for 18 hours (add 1.5 liters of NaOH solution per 1 kg of block seal skin), wash with water, and then wash with 0.3% (v / v) H at 2°C. 2 SO 4 Soak in the solution for 18 hours (add 1.5 liters of H for every 1kg of block seal skin 2 SO 4 solution), washed with water;

[0041] 2. Extract gelatin:

[0042] Make the pretreated bulk seal skin into a paste, add 1000ml of 0.05% (v / v) HCl solution for every 0.5kg paste seal skin, extract at 70°C for 12 hours, filter the gelatin extract, remove Precipitate, adding ordinary bleaching earth (diatomaceous earth) with a particle size of 150 meshes to the filtrate to make the bleaching earth content 5% (w / v), fully stirring, standin...

Embodiment 2

[0046] Step 1 and 2 are exactly the same as embodiment 1, but the proportioning in step 3 changes to some extent, specifically described as follows:

[0047] 3. Preparation of gelatin plasma:

[0048] Take 29g of pure sea dog gelatin, add 5.37g of sodium chloride for injection, 0.36g of potassium chloride, 0.13g of magnesium chloride, and 3.35g of sodium lactate, then add 1000ml of distilled water, filter the obtained solution, put it in a bag, and put it under a pressure of 103.41kPa. Sterilize and sterilize under autoclave for 15 minutes to obtain the finished product of gelatin instead of plasma.

Embodiment 3

[0050] Step 1 and 2 are exactly the same as embodiment 1, but the proportioning in step 3 changes to some extent, specifically described as follows:

[0051] 3. Preparation of gelatin plasma:

[0052] Take 31g of pure sea dog gelatin, add 5.39g of sodium chloride for injection, 0.38g of potassium chloride, 0.15g of magnesium chloride, and 3.37g of sodium lactate, then add 1000ml of distilled water, filter the obtained solution, put it in a bag, and put it under a pressure of 103.41kPa Sterilize and sterilize under autoclaving for 20 minutes to obtain the finished product of gelatin instead of plasma.

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PUM

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Abstract

The present invention relates to a kind of gelatin as blood plasma substitute and its preparation process. The blood plasma substitute is prepared with gelatin extracted from fur seal skin as material and possessing molecular weight 15000-36000. The blood plasma substitute consists of pure fur seal gelatin 29-31 g, sodium chloride for injection 5.37-5.39 g, potassium chloride 0.36-0.38 g, magnesium chloride 0.13-0.15 g, sodium lactate 3.35-3.37 g and distilled water 1000 ml. The blood plasma substitute is made to participate metabolism in body; has the functions of expanding blood capacity, maintaining essential osmotic pressure and improving blood circulation; and may be injected together with other intravenous injection to produce obvious curative effect and no toxic side effect.

Description

technical field [0001] The invention relates to a gelatin plasma substitute and a preparation method thereof. More precisely, the present invention relates to gelatin substitute plasma and its preparation method using fur dog skin as raw material. Background technique [0002] As we all know, plasma is the liquid part of circulating blood, which is an aqueous solution containing serum proteins, inorganic salts, electrolytes, glucose and fibrinogen. Plasma differs from serum, which is plasma from which fibrin has been separated during coagulation. When the human body encounters an emergency and suffers hemorrhagic shock, plasma is usually used as a lost blood substitute to expand blood volume to resist shock and achieve the purpose of first aid. In the rescue of hemorrhagic trauma, the required amount of plasma is also very large. With the spread of hepatitis and HIV, it is difficult to guarantee the safety of using human blood plasma and blood products, not to mention the...

Claims

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Application Information

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IPC IPC(8): A61K35/36A61K38/01A61K38/16A61P7/08
Inventor 何谓鉴刘威刘俊祥刘损
Owner 刘威
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