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Fukangzuo injection fluid and its preparation method

A fluconazole injection and fluconazole technology are applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., can solve problems such as inability to use, and achieve convenient portability, definite curative effect and low price. Effect

Inactive Publication Date: 2003-09-17
江西制药有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above two injections (large capacity) are subject to certain restrictions in clinical use. For example, injections containing sodium chloride cannot be used for patients who clinically limit sodium salts, and injections containing glucose are not suitable for some diabetic patients. limited use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Formula 1: Fluconazole 40g per 1000ml:

[0022] Fluconazole 40g

[0023] Propylene glycol 600ml

[0024] Activated carbon 3g

[0025] Add water for injection to 1000ml

[0026] Packed in 200 pieces, each 5ml

[0027] Preparation:

[0028] 1. Add fluconazole to propylene glycol at 60--80°C, stir to dissolve fluconazole, and cool to 40--50°C;

[0029] 2. Add activated carbon, add fresh water for injection to 1000ml, and stir for 15 minutes;

[0030] 3. Then remove the activated carbon through the sand core filter rod, and then finely filter through the φ0.65μm microporous membrane. The filtrate is tested for intermediates, and the pH value and the content of fluconazole in the solution are measured. After passing the test, it is potted and sealed. 200 ampoules, each 5ml;

[0031] 4. Disinfect and sterilize the filled ampoules in a disinfection cabinet, then use colored water to check for leaks, and then perform light inspection, pa...

Embodiment 2

[0033] Formula 2: 60g of fluconazole per 1000ml:

[0034] Fluconazole 60g

[0035] Propylene glycol 1000ml

[0036] Activated carbon 3g

[0037] 50 bottles, each 20ml

[0038] The preparation method is the same as in Example 1.

Embodiment 3

[0040] Formula 3: Fluconazole 20g per 1000ml:

[0041] Fluconazole 20g

[0042] Glycerol 300ml

[0043] Activated carbon 3g

[0044] Add water for injection to 1000ml

[0045] Packed in 1000 pieces, each 1ml

[0046] The preparation method is the same as in Example 1.

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PUM

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Abstract

A low-dosage fluconazole injection for preventing and treating mycotic infection by intravenous drip is prepared through dissolving fluoconazole in cosolvent, adding activated carbon and fresh water for injection, and certain conventional steps. its advantages are sure curative effect, low cost and not freezing at -20 deg.C.

Description

technical field [0001] The invention relates to medicines in the medical field, in particular to a small-capacity fluconazole injection with broad-spectrum antifungal effects and a preparation method thereof. Background technique [0002] Fluconazole (C 13 h 12 f 2 N 6 O) is a white crystalline powder, easily soluble in alcohol and slightly soluble in water. It is recorded in the Chinese Pharmacopoeia 2000 edition. It is a new type of triazole antifungal drug with broad-spectrum antifungal effect and can selectively inhibit Sterol synthesis by fungi, highly selective for inhibition of fungal cytochrome P-450-dependent enzymes. It has a good antibacterial effect on Cryptococcus and Candida in vivo and in vitro, and is the first choice for clinical antifungal infection. Because AIDS patients have low immunity and their mucous membranes are particularly susceptible to fungal infection, the drug can also be used as an adjuvant treatment for AIDS. [0003] Because of the ra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4196A61P31/10
Inventor 刘智
Owner 江西制药有限责任公司
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