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Method for extracting naringin

An extraction method and a technology of naringin, which are applied in the field of extracting naringin monomers, achieve the effects of high extraction yield, simple and feasible process, and simple extraction process

Inactive Publication Date: 2003-07-23
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The method for extracting naringin monomer from medicinal materials has not yet been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Cut the medicinal material of Fructus aurantii into decoction pieces, add 100°C water to submerge the medicinal material, extract three times with water, one hour each time, and filter; the filtrate is concentrated into an extract, passed through a macroporous resin column, eluted with water, and then eluted with 70% ethanol ; Collect the ethanol eluate, recover the ethanol from the eluent, obtain a precipitate, recrystallize the precipitate three times with water, and spray dry to obtain naringin monomer. The yield was 90.7%.

Embodiment 2

[0025] Crush the citrus medicinal materials without sieving, add 100°C water to submerge the medicinal materials, extract three times, each time for 1 hour, filter, and combine the filtrate; concentrate the filtrate, add absolute ethanol until the ethanol concentration is 30%, leave it overnight, filter, and supernatant Liquid recovery ethanol. Pass the extract through a silica gel column, elute with water first, and then elute with 80% ethanol; collect the ethanol eluate, recover ethanol from the eluate, obtain a precipitate, dry the precipitate, and recrystallize five times with absolute ethanol to obtain pomelo peel Glycoside monomer. The yield was 87.4%.

Embodiment 3

[0027] The red orange medicinal material is cut into decoction pieces, extracted twice with water at 70°C for 3 hours each time, filtered, and the filtrate is combined; the filtrate is concentrated into an extract, and the extract is added with 95% ethanol until the ethanol concentration is 60%, and left standing overnight to produce Precipitate, filter, remove the precipitate, recover ethanol from the filtrate, and elute the obtained liquid aluminum peroxide column with water first, and then with 95% ethanol; collect the ethanol eluate, recover and concentrate to obtain a precipitate, and weigh the precipitate with ethyl acetate Crystallize four times to get naringin monomer. The yield was 89.7%.

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Abstract

A process for extracting naringoside from medicinal materials including crushing, extracting more times, filtering, collecting filtration, concentrating, depositing in alcohol, column separation, eluting with organic solvent, volatilizing solvent, and recrystallizing more times. Its advantages are high extracting rate (85% or more), and high purity (95%).

Description

technical field [0001] The invention relates to a method for extracting naringin monomer from various medicinal materials containing naringin. Background technique [0002] Naringin is a flavonoid compound widely present in various Chinese herbal medicines, such as Citrus aurantium, Citrus aurantium, citrus, lemon, grapefruit, tangerine, orange, etc. Naringin is one of the main active ingredients of various medicinal materials. Studies have proved that naringin has antibacterial and anti-inflammatory effects, relieves cough and reduces phlegm, reduces plasma cholesterol concentration, and improves vascular circulation. It has been used as a bittering agent, sweating agent, and lowering cholesterol. [0003] The obtaining route of naringin, except Rosenmund (Rosenmund, Ber., 61,2608 (1958)) and Zemlen, the method described by Bognar (Ber., 75,648 (1942)) and other chemical methods are synthesized and obtained, also It can be obtained by extrac...

Claims

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Application Information

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IPC IPC(8): C07H1/08C07H17/07
Inventor 苏薇薇王永刚方铁铮彭维吴忠
Owner SUN YAT SEN UNIV
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