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Extraction of ÔÇÿzuojinÔÇÖ total alkaloid and its application

A technology of total alkaloids and Zuojin, which is applied in the extraction of total alkaloids of Zuojin and its application field, can solve the problems of preparation preparation difficulties, poor preparation quality, large dosage, etc., and achieve easy preparation of preparations, poor hygroscopicity, The effect of high purity

Inactive Publication Date: 2003-07-23
GUIYANG HAOZHEN PHARMA DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the production process of Zuojin medicine, the extraction of raw materials is decocted and extracted (or directly crushed to make finished medicine), and the extract obtained by this method is an extract, which has low purity and strong hygroscopicity. , preparation preparation is difficult, the quality of the preparation is poor, and the dosage is large

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1. Extract the total alkaloids of Zuojin according to the following steps.

[0015] a, material preparation: take 6 Kg of Coptidis Rhizoma and 1 Kg of Evodia Evodia as raw materials, grind Coptis Rhizoma and Evodia Evodia into coarse powder respectively, and then mix them to obtain product A;

[0016] b. Extraction: Add 56Kg of methanol hydrochloride with a concentration of 1% as the extraction solvent to product A, heat and reflux for extraction twice, each time for 2 hours, filter, and combine the filtrates to obtain methanol hydrochloride extract; Double the amount of water and decoct twice, each time for 2 hours, filter, combine the decoction, concentrate to a relative density of 1.1, and obtain a concentrated solution; mix the hydrochloric acid methanol extract with the concentrated solution, place the precipitate, suction filter, and recover the methanol from the filtrate get product B;

[0017] c. Add 14Kg 200-300-mesh neutral alumina to product B, mix ...

Embodiment 2

[0019] Example 2. Extract the total alkaloids of Zuojin according to the following steps.

[0020] a, material preparation: take 6 Kg of Coptidis Rhizoma and 1 Kg of Evodia Evodia as raw materials, grind Coptis Rhizoma and Evodia Evodia into coarse powder respectively, and then mix them to obtain product A;

[0021] b. Extraction: add 50Kg of methanol hydrochloride with a concentration of 1.2% to product A as the extraction solvent, heat and reflux for extraction twice, each time for 1 hour, filter, and combine the filtrates to obtain methanol hydrochloride extract; Double the amount of water and decoct twice, each time for 2 hours, filter, combine the decoction, concentrate to a relative density of 1.1, and obtain a concentrated solution; mix the hydrochloric acid methanol extract with the concentrated solution, place the precipitate, suction filter, and recover the methanol from the filtrate get product B;

[0022] c. Add 20Kg 200-300-mesh neutral alumina to product B, mix...

Embodiment 3

[0024] Example 3. Extract the total alkaloids of Zuojin according to the following steps.

[0025] a, material preparation: take 6 Kg of Coptidis Rhizoma and 1 Kg of Evodia Evodia as raw materials, grind Coptis Rhizoma and Evodia Evodia into coarse powder respectively, and then mix them to obtain product A;

[0026] b. Extraction: Add 60Kg of methanol hydrochloride with a concentration of 0.8% as the extraction solvent to product A, heat and reflux for extraction twice, each time for 2 hours, filter, and combine the filtrates to obtain methanol hydrochloride extract; Decoct twice the amount of water for 2 hours each time, filter, combine the decoction liquid, concentrate to a relative density of 0.9, and obtain a concentrated liquid; mix the hydrochloric acid methanol extract with the concentrated liquid, place for precipitation, suction filter, and recover the methanol from the filtrate get product B;

[0027] c. Add 17Kg 200-300-mesh neutral alumina to product B, mix well,...

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Abstract

A Zuojin alkaloid used for preparing different medicines is prepared from coptis root and evodia fruit through breaking, mixing, adding methanol hydrochloride, thermal reflux, filtering to obtain theliquid extract, decocting the dregs, filtering, concentrating to obtain liquid, mixing two kinds of liquid together, deposition, pumping filter, recovering methanol, adding alumina, mixing, drying, thermal reflux extracting with alcohol, crystallizing, filtering and drying. Its advantages are high purity and high feasibility.

Description

technical field [0001] The invention relates to a method for extracting effective components of Chinese medicinal materials and the application of the extract, in particular to a method for extracting total alkaloids from Chinese medicinal materials and the application of the total alkaloids. Background technique [0002] Zuojin medicine has a good curative effect on acute and chronic gastritis, enteritis, gastric ulcer and other diseases. However, in the production process of Zuojin medicine, the extraction of raw materials is decocted and extracted (or directly crushed to make finished medicine), and the extract obtained by this method is an extract, which has low purity and strong hygroscopicity. , the preparation is difficult, the quality of the preparation is poor, and the dosage is large. Contents of the invention [0003] The object of the present invention is to provide an extraction and application method of total alkaloids of left gold. The extract obtained by ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P1/04C07G5/00
Inventor 杨亮郭晶范宝成
Owner GUIYANG HAOZHEN PHARMA DEV
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