Improved stannous oral compositions
An oral composition and the technology of the composition are applied in the direction of drug combination, oral care, dentistry, etc., and can solve the problems of unacceptable astringency of the preparation, reduction of tooth staining, loss of antibacterial/anti-plaque activity, etc.
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Examples
Embodiment I
[0099] Example I is a two-phase dentifrice composition. Sodium polyphosphate (Glass H of FMC Corporation, n=21 unit condensed phosphate polymer) is included in the first dentifrice composition, stannous fluoride and other stannous Salt is included in the second dentifrice composition.
[0100] Ingredients
Formulation 1a
Formulation 2a
Formulation 3a
Formulation 4a
0.500
0.200
0.200
0.300
Water
2.210
-
-
1.400
1.500
1.100
1.100
1.100
Glycerin
29.890
45.550
43.550
39.850
Polyethylene glycol
1.500
-
-
6.000
0.200
-
-
-
8.000
-
-
-
10.000
8.000
10.00...
Embodiment II
[0110] Example II is a single-phase dentifrice composition, including stannous salt, Glass H polyphosphate or polyphosphonate suspension and different fluoride ion sources, formulated with low water bottom materials to ensure the polymerization of MSA and stannous ions stability. Another example is the stannous dentifrice described in US Patent 5,004,594 by Majeti et al.
preparation Embodiment II
[0111] The compositions of Example II (formulations A-D) were prepared as follows: glycerin and thickener were added to the main mixing tank and mixed. If possible, add sodium gluconate to it and mix well. Add sodium lauryl sulfate solution and flavor, and stir until the thickener is hydrated / dissolved. Add silicon dioxide and titanium dioxide and mix well. Add stannous and / or fluoride salt and mix well. Finally, add polymer surfactant (Glass H or polyphosphonate) and mix well.
[0112] Ingredients
Formulation A
Formulation B
Formulation C
Formulation D
Comparative example
1.00
1.200
1.500
1.150
1.000
Glycerin
53.166
54.300
52.872
9.000
14.425
Poloxamer 407
5.000
3.000
8.000
-
-
Stannous chloride
0.680
-
-
1.500
1.500
-
1...
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