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Melatonin composition with soporific effect and its prepn

A technology of melatonin and composition, applied in the field of melatonin composition with hypnotic effect and its preparation, can solve the problems of strong side effects, limited application population, unsatisfactory patients, etc. The best, the effect of expanding the scope of application

Inactive Publication Date: 2003-05-14
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs have strong side effects and cannot satisfy patients.
The body's endogenous hypnotic substance melatonin can induce physiological sleep without the toxic and side effects of benzodiazepines. In recent years, more and more people use melatonin to treat insomnia, but the hypnotic effect of melatonin is relatively low. Weak, and has a certain inhibitory effect on the reproductive system of young and middle-aged people, which limits its application population

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0006] Extraction of spinous date kernels: crush the fried spiny date kernels with a grinder, and take the sifted fine powder for later use.

[0007] Extraction of Epimedium: Take a certain amount of Epimedium and soak in water for 1 hour, heat to a slight boil for 1 hour, filter, add water to the filter residue and boil for 1 hour, filter, combine the two filtrates, evaporate excess water in a 70°C water bath, Concentrate, dry under reduced pressure and grind into fine powder for use.

[0008] The melatonin, vitamin B6, wild jujube seed, epimedium and zinc gluconate are evenly mixed to make dosage forms such as tablets or capsules to obtain the melatonin composition.

Embodiment 2

[0010] Animals: male mice, 18-22g was used in the experiment of prolonging the sleep time of mice with pentobarbital sodium by the melatonin composition.

[0011] Drugs: melatonin, jujube seed, epimedium, vitamin B6, zinc gluconate, pentobarbital sodium.

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Abstract

The present invention can eliminate the inhibition of melatonin on genital system and expands its application range. The melatonin compostion incldues melatonin, vitamin B6, soporific Chinese medicine components, kidney invigorating and Yang strengthening Chinese medicine components, zinc gluconate and medicinal carrier. Its preparation process includes crushing fried common jujube kernel; soaking, boiling and filtering crushed common jujube kernel and epimedium; concentration, decompression drying, grinding into medicine powder; mixing all the medicinal components; and tabletting or capsulizing.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to a melatonin composition with hypnotic effect and a preparation method thereof. Background technique: [0002] Insomnia and sleep-wake rhythm disturbances are common diseases that can seriously affect human health. Benzodiazepines have been used clinically for many years. However, these drugs have strong side effects and cannot satisfy patients. The body's endogenous hypnotic substance melatonin can induce physiological sleep without the toxic and side effects of benzodiazepines. In recent years, more and more people use melatonin to treat insomnia, but the hypnotic effect of melatonin is relatively low. It is weak, and has a certain inhibitory effect on the reproductive system of young and middle-aged people, which limits its application population. The composition improves the therapeutic effect of melatonin and expands the application range of the medicine. Invention con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P25/20
Inventor 李经才王芳徐峰韩向晖张若明
Owner SHENYANG PHARMA UNIVERSITY
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