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Preparation method of affinity polysulfone-chitosan compound asymmetrical ultrafiltration film

A technology of chitosan and ultrafiltration membranes, applied in chemical instruments and methods, membrane technology, semipermeable membrane separation, etc., can solve problems such as complex activation methods, single active groups, and no consideration of the internal structure of the membrane, and achieve Ideal pore structure, simple preparation method, and good mechanical strength

Inactive Publication Date: 2003-04-30
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above methods all introduce a certain number of active groups and improve the hydrophilic properties of the membrane to a certain extent, but

Method used

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  • Preparation method of affinity polysulfone-chitosan compound asymmetrical ultrafiltration film
  • Preparation method of affinity polysulfone-chitosan compound asymmetrical ultrafiltration film
  • Preparation method of affinity polysulfone-chitosan compound asymmetrical ultrafiltration film

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0011] Example 1: 1. Preparation of chloromethylated polysulfone asymmetric membrane

[0012] Take the chloromethylated polysulfone and polyethylene glycol and place them in dimethylformamide, the chloromethylated polysulfone / polyethylene glycol is 4 / 1, the molecular weight of polyethylene glycol is 600, 80-85℃ Stir for 12 hours. Then put the casting solution in a dark place and stand for 24 hours. Pour the casting liquid on the glass plate, the temperature of the glass plate is 50 ℃, scrape with a spatula to form a film, evaporate for 30 seconds, immerse in distilled water, and solidify for 1 hour. The solidified membrane was taken out and rinsed with running water for 24 hours to obtain a chloromethylated polysulfone asymmetric membrane with through holes at the bottom. 2. Preparation of hydroxymethyl polysulfone membrane

[0013] Take the chloromethylated polysulfone membrane prepared in step 1 and place it in a 15% soda ash solution and shake at a constant temperature of 85° C...

Example Embodiment

[0015] Embodiment two:

[0016] Take the chloromethylated polysulfone and ethylene glycol monomethyl ether and place them in N-methylpyrrolidone, the chloromethylated polysulfone / ethylene glycol monomethyl ether is 4 / 1, and stir at 80-85°C for 15 hours. Then put the casting solution in a dark place and stand for 24 hours. Pour the casting liquid on the glass plate, the temperature of the glass plate is 70 ℃, scrape with a scraper to form a film, evaporate for 1 minute, immerse in a 10% propionic acid solution, and solidify for 1 hour. The solidified film was taken out and rinsed with running water for 24 hours. The chloromethylated polysulfone asymmetric membrane is obtained.

[0017] The hydroxymethyl polysulfone membrane and polysulfone-chitosan composite membrane were prepared according to the scheme of Example 1.

Example Embodiment

[0018] Embodiment three:

[0019] Dissolve 80 mg of sodium borohydride in 12 ml of 2M NaOH, add 20 ml of water and 4 ml of dioxirane. The methylol polysulfone membrane prepared in Example 1 was placed in the above solution, shaken and activated at room temperature for 4 hours, and then washed with distilled water 3 times. The activated membrane was placed in a 2% chitosan acetic acid solution with an acetic acid concentration of 10% (volume), shaken at 40°C for 5 hours, and then placed in an oven at 120°C to dry for 4 hours. The dried membrane was washed with 1% acetic acid solution for 1 hour, and washed with a large amount of distilled water for 1 day to obtain a polysulfone-chitosan composite membrane.

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Abstract

A process for preparing asymmetric ultrafilter affinity polysulfone-chitosan membrane includes such steps as hydrolyzing the chloromethylated polysulfone as basic material in alkaline aqueous solution at 50-90 deg.C to obtain hydroxymethyl polysulfone membrane, and directly or indirectly reaction with the acidic aqueous solution of chitosan for coupling chitosan to obtain the target membrane. Its advantages are high hydrophilicity and mechanical strength, low non-specific adsorpativity, and ideal artery structure.

Description

technical field [0001] The invention relates to a method for preparing an affinity polysulfone-chitosan composite asymmetric ultrafiltration membrane, which belongs to the preparation technology of the composite ultrafiltration membrane. Background technique [0002] Affinity ultrafiltration is to use the pore size of the membrane and the ligands bonded on the surface of the membrane and in the pores to separate and purify the sample solution. It can not only separate the target biomolecules from other molecules, but also remove part of the solvent to achieve purpose of concentration. Polysulfone has been widely used in ultrafiltration technology due to its superior film-forming properties and good chemical stability, but its inherent hydrophobicity and no functional groups on the molecule can be directly used to immobilize biomacromolecules. So that it cannot be directly used as a medium for affinity separation, it must be chemically modified. A...

Claims

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Application Information

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IPC IPC(8): B01D69/12B01D71/08B01D71/68
Inventor 石巍张凤宝张国亮王淑兰赵永江
Owner TIANJIN UNIV
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