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Chinese medicine injection for treating acute cerebral hemorrhage and preparation method thereof

A technology of injection and traditional Chinese medicine, which is applied in blood diseases, medical preparations containing active ingredients, drug combinations, etc. The effect of improving hemiplegia signs and neurological deficits and reducing mortality

Inactive Publication Date: 2002-10-02
张平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Chinese medicine has Angongniuhuang Pills, Zhibaodan, Suhexiang Pills, and Shenfu Decoction for acute cerebral hemorrhage, it is extremely inconvenient to use them clinically.
Until now, there is still no effective drug for the treatment of acute cerebral hemorrhage in clinical practice.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Weigh 50g of antelope horn, 200g of Moutan cortex, 120g of Shichangpu, and 100g of gardenia as raw materials. The above four flavors and antelope horns were beaten into coarse powder, and 10 times the amount of 1mol / L sulfuric acid was added to reflux for hydrolysis for 6 hours. The hydrolyzed solution was neutralized to pH 3.8 with barium hydroxide, filtered, and the filtrate was concentrated under reduced pressure to a relative density of 1.12 ( 50°C), use ethanol precipitation treatment twice, the first time to make the alcohol content 70%, the second time to 70-85%, refrigerate for 60 hours, filter, recover the ethanol and concentrate to a relative density of 1.35 (60°C ) thick paste, dried under vacuum at 6.86KPa and 70°C to obtain antelope horn extract with a yield of about 8.23%. Acorus calamus was crushed into 2cm coarse grains, added 20 times the amount of water, extracted by steam distillation for 12 hours, collected volatile oil, the oil yield was about 1.07m...

Embodiment 2

[0021]Weigh 30g of antelope horn, 150g of peony bark, 150g of calamus calamus and 120g of gardenia as raw materials. The above four flavors and antelope horns were beaten into coarse powder, and 8 times the amount of 1mol / L sulfuric acid was added to reflux for hydrolysis for 10 hours. The hydrolyzed solution was neutralized to pH 4.2 with barium hydroxide, filtered, and the filtrate was concentrated under reduced pressure to a relative density of 1.2 ( 50°C), use ethanol precipitation treatment twice, the first time to make the alcohol content 60%, the second time to 85%, refrigerate for 24 hours, filter, recover the ethanol and concentrate to a relative density of 1.3 (60°C) The thick paste was vacuum-dried at 6.86KPa and 70°C to obtain an antelope horn extract with a yield of about 9.1%. Acorus calamus was crushed into 1cm coarse grains, added 15 times the amount of water, extracted by steam distillation for 10 hours, and the volatile oil was collected. The oil yield was ab...

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Abstract

The present invention discloses a Chinese medicine injection for curing acute cerebral hemorrhage. It is made of (by weight ratio) antelope horn 1-70, moutan root bark 4-164, acorus root 2-60 and gardenia fruit 10-120 as raw material. Said invention also discloses its preparation method, and said injection possesses the good therapeutic effect.

Description

Technical field [0001] The invention relates to a medicine for treating acute cerebral hemorrhage, in particular to an injection for treating acute cerebral hemorrhage, and also relates to a preparation method of the injection. Background technique [0002] Cerebral hemorrhage is one of the main diseases of acute cerebrovascular disease. Because it seriously endangers people's health and has a high death and disability rate, governments and health departments of various countries pay more and more attention to its prevention and treatment. Epidemiological surveys show that the prevalence of cerebrovascular disease is 500-700 / 100,000 population, which is basically consistent with domestic and foreign statistics. In some cities in my country, it is as high as 1,000 / 100,000 population, and the annual incidence rate is 165-245 / 100,000 population. my country is one of the high-incidence areas of cerebrovascular disease in the world. Cerebrovascular disease has been the second cau...

Claims

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Application Information

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IPC IPC(8): A61K35/32A61P7/04A61P9/10
Inventor 张平
Owner 张平
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