Prepn process of 2,4-dichlorofluorobenzene

A technology for dichlorofluorobenzene and production process, which is applied in the field of preparation 2, can solve the problems of production restriction of 2,4-dichlorofluorobenzene, lack of competitive advantages, and high raw material prices, and achieves avoiding danger of explosion, low price, and high investment. low effect

Inactive Publication Date: 2002-07-10
昆山虹祺药业有限责任公司
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AI Technical Summary

Problems solved by technology

[0003] The present invention aims to solve the problem that the production of 2,4-dichlorofluorobenzene is limited and lacks competitive advantages due to the high price and explosiveness of raw materials used in the preparation of 2,4-dichlorofluorobenzene

Method used

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specific Embodiment approach

[0010] Embodiment, ①. Weigh 803 grams of o-chloronitrobenzene and 16 grams of anhydrous ferric chloride, drop into a 1000 milliliter four-necked flask, heat with an oil bath, and start stirring to heat up to about 55 degrees Celsius, ferric chloride in the bottle After complete dissolution, feed chlorine gas and control the flow of chlorine gas to maintain the reaction temperature in the range of 90-100 degrees Celsius. As the reaction progresses, the amount of chlorine gas feeding can be appropriately reduced to maintain the reaction time for 8-10 hours. Stop chlorine and heating, wash the reactant several times with hot water in the separatory funnel, the material turns from reddish brown to light yellow, and the organic phase is washed twice with dilute sodium carbonate solution, and then washed with hot water until neutral. The product 2,5-dichloronitrobenzene was obtained.

[0011] ②. In turn, add 24.63 grams of fried potassium fluoride, 8.064 grams of cetyltrimethylammon...

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Abstract

The present invention prepares 2,4-dichlorofluorobenzene by using o-chloronitrobenzene as raw material and through the steps of: electrophilic substitution reaction between o-chloronitrobenzene and chlorine gas on benzene ring in the presence of catalyst; the reaction between the refined product of the fore reaction and potassium fluoride, filtering and washing to obtain 2-fluoro-5-chloronitrobenzene; chlorination of 2-fluoro-5-chloronitrobenzene at high temperature to obtain the product 2,4-dichlorofluorobenzene. The present invention has low material cost and no explosion danger.

Description

(1) Technical field [0001] The invention relates to a new production process for preparing 2,4-dichlorofluorobenzene, in particular to a new production process for preparing 2,4-dichlorofluorobenzene from o-chloronitrobenzene. (2) Background technology [0002] 2,4-Dichlorofluorobenzene (2,4-Dichlorofluorobenzene) is the main intermediate for the synthesis of ciprofloxacin. Ciprofloxacin is a new type of fluoroquinolone antibacterial drug. The advantage of low toxicity and side effects. At present, 2,4-dichlorofluorobenzene is mainly synthesized from fluorobenzene or 2,4-dinitrochlorobenzene in China. Due to the high price of raw materials and the explosive nature of dinitro compounds, 2,4-dichlorofluorobenzene The production of benzene is limited and lacks competitive advantages. (3) Contents of the invention [0003] The present invention aims to solve the problem that the production of 2,4-dichlorofluorobenzene is limited and lacks competitive advantages due to the hi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C17/12C07C25/13
Inventor 王斌王皆胜
Owner 昆山虹祺药业有限责任公司
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