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Active component of red sage root, its slowly releasing medicine and medical purpose, and its preparing process

A technology of effective parts and sustained-release preparations, which is applied in the field of medicine and can solve problems such as inconvenient taking, poor stability, and low content of active ingredients

Inactive Publication Date: 2002-06-12
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] As a drug for treating cardiovascular diseases, the traditional Chinese medicine Salvia miltiorrhiza has a wide range of clinical applications, has a broad basis for clinical medication, and has significant curative effects. However, this traditional Chinese medicine has disadvantages such as inconvenience in taking, low content of active ingredients, and poor stability.

Method used

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  • Active component of red sage root, its slowly releasing medicine and medical purpose, and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Preparation of the effective part of Danshen: crush the medicinal material of Danshen into a coarse powder, add 10 times the weight of the medicinal material in water, heat and extract twice at 80°C for 1.5 hours each time, filter, combine the secondary extracts, and quickly cool to room temperature. According to the ratio of the amount of the upper column sample (equivalent medicinal material) to the amount of wet resin (1:8 / W:V), perform polyamide adsorption column chromatography, and use water at 1-2ml / cm 2 / min flow rate eluted 10 column bed volumes, followed by 60% ethanol 1-2ml / cm 2 The flow rate of / min eluted 10 column bed volumes, and the eluted part of 60% ethanol was the effective part of the total phenolic acid of salvia miltiorrhiza, and the solvent was recovered under reduced pressure at about 70°C to a liquid extract with a specific gravity of 1.09-1.11. The above liquid extract of salvia miltiorrhiza phenolic acid is dried under reduced pressure and vacu...

Embodiment 2

[0018] Preparation of Danshen Sustained-release Coated Pellets

[0019] Among them: pill heart prescription:

[0020] Effective part of Danshen 20mg

[0021] Vc 1mg

[0022] Sodium chloride 8mg

[0023] Sodium carboxymethyl starch 25mg

[0024] Lactose 42mg

[0025] Coating solution prescription 1 (dosage per 100ml):

[0026] Ethylcellulose 3g

[0027] PEG400 2g

[0028] Diethyl phthalate 0.6g

[0029] Ethanol to 100ml

[0030] Coating solution prescription 2 (dosage per 100ml):

[0031] Ethylcellulose 3g

[0032] PEG400 1.3g

[0033] Diethyl phthalate 0.6g

[0034] Ethanol to 100ml

[0035] Coating solution prescription 3 (dosage per 100ml):

[0036] Ethylcellulose 3g

[0037] PEG4000.3g

[0038] Diethyl phthalate 0.6g

[0039] Ethanol to 100ml

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Abstract

An active component of red sage root, its slow-releasing agent, its medicinal application, and its preparing process are disclosed. In its effective region, the content of general solviolic acid is more than 80% and the content of salviolic acid A is more than 10%. Said slow-releasing agent is prepared through extracting in water or alcohol ic water, getting a supernatant, removing alcohol, dissolving in water, then washing to remove inpurities, eduting with alcohol, recovering alcohol eluent and drying. It can be used to prepare the medicine to prevent and cure cardiovascular and cerebrovascular diseases.

Description

Technical field: [0001] The invention relates to the technical field of medicine, specifically, it is an effective part of the traditional Chinese medicine Salvia miltiorrhiza that can be expected to be used as an anti-cardiovascular and cerebrovascular disease drug, its slow-release preparation, its medical application and its preparation method. Background technique: [0002] The traditional Chinese medicine Salvia miltiorrhiza has a wide range of clinical applications as a drug for treating cardiovascular diseases, has a broad clinical drug basis, and has significant curative effects. However, this traditional Chinese medicine has disadvantages such as inconvenience in taking, low content of active ingredients, and poor stability. Invention content: [0003] The invention provides an effective part of the traditional Chinese medicine salvia miltiorrhiza and its slow-release preparation, medical application and preparation method. The sustained-release preparations inclu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/30A61K9/56A61P9/10
Inventor 王金辉唐星潘文军赵怀清李铣
Owner SHENYANG PHARMA UNIVERSITY
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