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(R)-beta-phenylacetylamino-beta-phenylpropionic acid compounds

A technology of phenylacetamide and phenylpropionic acid, applied in the field of medicine, can solve problems such as hypoglycemia and lower glucose levels

Inactive Publication Date: 2002-05-08
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs have their own disadvantages, such as sulfonylurea hypoglycemic drugs, which can stimulate the secretion of insulin for a long period of time and reduce the overall glucose level, thus leading to the occurrence of overall hypoglycemia

Method used

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  • (R)-beta-phenylacetylamino-beta-phenylpropionic acid compounds

Examples

Experimental program
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Effect test

Embodiment Construction

[0006] (R)-β-Phenylacetamido-β-O-methoxyphenylpropionic acid (code name AD)

[0007] Add 20.9g of 3-amino-3-(o-methoxyphenyl)propionic acid to 100ml of chloroform and 100ml of ethanol, add 4.4g of sodium hydroxide, stir, add 22ml of triethylamine, and cool the solution to 0°C. 16.65g of phenylacetyl chloride was dissolved in 50ml of chloroform and added dropwise to the above solution. The rate of dropping was controlled so that the temperature of the inner bath was lower than 5°C. After the dropping, the reaction was kept warm for 60 minutes, raised to room temperature, filtered with suction, and the filtrate was concentrated to the original Add 1 / 3 of the volume, add 100ml of water to the residue, shake well, adjust the pH to 3 with hydrochloric acid, stand still, separate the water layer, adjust the pH to 3 again, extract with chloroform, combine the organic phases, and dry with anhydrous sodium sulfate. The desiccant was filtered off, the filtrate was concentrated, and the resi...

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Abstract

The present invention, (R)-beta-phenylacetylamino-beta-phenylpropionic acid compound, is one compound for treating diabetes with obvious blood sugar lowering effect and less side effect. It is produced through condensation between phenylacetyl compound and 3-amino-beta-3-phenylpropionic acid compound.

Description

Technical field: [0001] The present invention relates to the field of medical technology, and to be precise, it is a compound (R)-β-phenylacetamido-β-phenylpropionic acid compound for treating diabetes. Background technique: [0002] Diabetes is a frequently-occurring disease. In recent years, with the improvement of people's living standards, its incidence has increased. At present, there are no specific drugs for the treatment of diabetes, and insulin, sulfonylureas and metformin are still dominant. However, these drugs have their own shortcomings, such as sulfonylurea hypoglycemic drugs, which can stimulate the secretion of insulin for a long period of time and reduce the level of glucose in an all-round way, thus leading to the occurrence of overall hypoglycemia. Therefore, finding new anti-diabetic drugs with high efficiency and low side effects has always been an important topic in the field of new drug research. Summary of the invention: [0003] The purpose of the presen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C233/51
Inventor 宫平
Owner SHENYANG PHARMA UNIVERSITY
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