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New method for detecting esophageal cancer haemocyanin fingerprint

A serum protein and serum technology, applied in biochemical equipment and methods, biological testing, measuring devices, etc., can solve the problems of low sensitivity and poor specificity, and achieve the effect of high sensitivity, small sample volume and strong specificity

Inactive Publication Date: 2007-04-11
CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Serum markers currently available for auxiliary diagnosis, curative effect evaluation and postoperative follow-up of esophageal cancer mainly include: carcinoembryonic antigen (CEA), squamous cell carcinoma-related antigen (SCC), cytokeratin protein fragment 19 (CYFRA21-1 ), p53 protein antibody (p53-Ab), etc., although they have certain clinical application value, they have low sensitivity and poor specificity

Method used

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  • New method for detecting esophageal cancer haemocyanin fingerprint
  • New method for detecting esophageal cancer haemocyanin fingerprint
  • New method for detecting esophageal cancer haemocyanin fingerprint

Examples

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Effect test

Embodiment 1

[0022] A method for detecting serum protein fingerprints of esophageal cancer, the steps are as follows:

[0023] Collect serum samples from the esophageal cancer group, the control group, the early esophageal cancer group, the benign esophageal disease group and other malignant tumor groups;

[0024] in,

[0025] The esophageal cancer group is a total of 199 cases of esophageal cancer diagnosed by clinical pathology and surgical treatment alone;

[0026] The control group consisted of age- and gender-matched non-tumor healthy volunteers, a total of 106 cases;

[0027] The early esophageal cancer group included 14 cases of early esophageal minimal lesion (carcinoma in situ);

[0028] Benign esophageal disease group included esophagitis, reflux esophagitis, and esophageal leiomyoma, a total of 10 cases; other malignant tumor group included other malignant tumors of the digestive system, a total of 30 cases.

[0029] In this example, 3ml (milliliters) of whole blood was colle...

Embodiment 2

[0035] A new method for detecting the serum protein fingerprint of esophageal cancer, the steps are as follows:

[0036] Serum samples of esophageal cancer group, control group, early esophageal cancer group, benign esophageal disease group and other malignant tumors were collected.

[0037] in,

[0038] The esophageal cancer group is a total of 199 cases of simple surgical treatment of esophageal cancer diagnosed by clinicopathology;

[0039] The control group consisted of 106 age- and gender-matched non-tumor healthy volunteers;

[0040] The early esophageal cancer group included 14 early esophageal cancer minimal lesion cases;

[0041] Benign esophageal disease group included esophagitis, reflux esophagitis, and esophageal leiomyoma, a total of 10 cases; other malignant tumor group included other malignant tumors of the digestive system, a total of 30 cases.

[0042] In this example, 3ml of whole blood was collected intravenously from the subject on an empty stomach in t...

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Abstract

The present invention relates to one method of detecting serum protein fingerprint of esophagus cancer. The serum protein fingerprint is obtained through collecting human serum, combining human serum with weak cationic affinity protein chip, reading serum protein map in mass spectrograph and analyzing the map data with protein fingerprint analyzing software. The serum protein fingerprint of esophagus cancer consists of 12 proteins with different mass-to-charge ratios. The serum protein fingerprint of esophagus cancer the present invention provides may be used in the early detection of esophagus cancer and has sensitivity and specificity over 80 %.

Description

technical field [0001] The invention relates to a new method for detecting the serum protein fingerprint of esophageal cancer. The method can determine the sensitivity and specificity index of the serum protein fingerprint standard of esophageal cancer, and provides beneficial help for early discovery, early diagnosis and early treatment of esophageal cancer. Background technique [0002] With the unprecedented scale and speed of global genome projects, especially the Human Genome Project, scientists have now turned their attention to the human proteome—the wide variety of proteins made by human tissues and cells. Although the human genome contains all the genetic information of our body, it is only the raw material for making proteins, and it is proteins that make up cells and perform various functions. Protein is also the determinant of the differences between different types of cells in the body. Although all cells have the same genome, different genes are active in diffe...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N30/72C12Q1/68G01N30/00
Inventor 赵晓航许洋毛友生
Owner CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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