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Preparation of medicine preparation of orthopedics department and its use

A technology of medicine and orthopedics, applied in the field of preparation and clinical application, can solve the problems of single dosage form, slow onset of effect, and few varieties

Inactive Publication Date: 2007-02-14
SHANXI PUDE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current clinical application shows that "Songmei Le" has a positive curative effect, and the patient's tolerance is significantly better than that of chemical drugs; however, at present, there are few types of such drugs, a single dosage form, relatively slow onset of effect, and a long medication cycle

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1, the preparation method 1 of deer bone extract

[0049] Take 100g of deer bone, crush it into a coarse powder, add 5 times the amount of deionized water, reflux extraction four times, each time for 1 hour, combine the extracts, concentrate under reduced pressure to form a fluid extract, add 5 times the amount of 80% ethanol, and stir well , let it stand for more than 12 hours, filter, wash the precipitate with 80% ethanol, combine the lotion with the filtrate, recover the ethanol, concentrate under reduced pressure until every 1g of the concentrated solution contains 2g of the original medicinal material, then add 7 times the amount of ethanol, and fully stir, Let it stand for 12 hours, filter, wash the precipitate with ethanol, combine the lotion with the filtrate, recover the ethanol and concentrate under reduced pressure until each 1g of the concentrated solution contains 2g of the original medicinal material, carry out alcohol precipitation according to ...

Embodiment 2

[0050] Embodiment 2, the preparation method 2 of deer bone extract

[0051] Take 100kg deer bone, add 200L deionized water, pressurize and heat extract for 1 hour, repeat the extraction 4 times, and combine the extracts. Add appropriate concentration of acid solution (hydrochloric acid or sulfuric acid) to adjust the pH of the extract to between 3 and 4, stand still for 10 to 15 hours, remove the precipitate, take the supernatant, boil, add lye to adjust the pH to between 7 and 8 , place, filter, take the supernatant, and freeze-dry to obtain the deer bone extract.

Embodiment 3

[0052] Embodiment 3, composition powder injection preparation 1

[0053] Preparation prescription:

[0054] Notoginseng Saponin Extract 100g

[0055] Deer bone extract 300g

[0056] Mannitol 400g

[0057] Add water for injection to 6000ml

[0058] Make 1000 pieces

[0059] Preparation method: according to the above preparation prescription, dissolve the notoginseng saponin extract, deer bone extract and scaffold agent mannitol in water for injection, add an appropriate amount of activated carbon, boil at 100°C for 15 minutes, and let stand for 12 hours; filter and adjust the pH to 7.0; Dispense into 10ml vials, 6mL each; freeze-dry in a freeze dryer at -40°C for 5 hours; sublimate at -15°C to 20°C for 24 hours in total; dry at 40°C for 2 hours; press Seal the lid and serve.

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Abstract

The present invention discloses a kind of medicine composition for preventing and treating orthopaedics diseases, and the medicine composition consists of deer bone extract and saponin extract with the functions of promoting blood circulation to disperse blood clots. Experiments show that the deer bone extract has obvious synergistic effect on notoginseng saponin, achyranthes root saponin and beta-aescin sodium, and the medicine composition can remit various symptoms of osteoarthritis and speed the healing of fracture. The medicine composition may be prepared into different preparation forms and has wide application foreground.

Description

Field of invention: [0001] The present invention relates to a pharmaceutical composition for treating orthopedics, and mainly relates to the preparation of the pharmaceutical composition preparation and its clinical application. Background of the invention: [0002] Orthopedic diseases, including various arthritis, joint injuries, and fractures, are common and sudden diseases. Because orthopedic diseases are often complicated with multiple complications, orthopedic drugs are receiving more and more attention. Statistics show that the total prevalence rate of osteoarthritis (OA) in my country is about 15%, the prevalence rate of 40-year-old population is 10%-17%, and the prevalence rate of people over 60 years old is 50%. Among people over the age of 75, 80% suffer from osteoarthritis, and the final disability rate of the disease is 53%. As our country gradually enters an aging society, the prevention and treatment of various orthopedic diseases will inevitably face more and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61K36/21A61K35/32A61K9/00A61P19/08
Inventor 张帆
Owner SHANXI PUDE PHARMA CO LTD
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