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Biologic synthesis of perylene quinone compound

A technology for biosynthesis and compound, applied in the field of biocatalytic synthesis of compounds, can solve the problems of cumbersome artificial synthesis steps, low total amount of perylene quinone compounds and the like

Inactive Publication Date: 2007-01-17
YUNNAN UNIV
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Problems solved by technology

However, the artificial synthesis steps are cumbersome, and the synthesis of perylenequinone skeleton compounds through more than a dozen steps of reactions is only of theoretical research significance, and a large amount of perylenequinone compounds can only be obtained through biosynthesis
Although there are some documents so far that have initially explored the biosynthesis of perylenequinone compounds, such as "Biocatalytic synthesis of perylenequinone compounds" ("Molecular Catalysis", 2000, 14 (14), 300-302); Biosynthesis" ("Journal of Tropical Crops", 1998, 19 (Supplement), 45); "Study on solid-state fermentation process of perylene quinones producing bacteria" ("Journal of Yunnan University", Natural Science Edition, 2000, 22(5), 389 -391) and other articles are all grown in the mountainous area of ​​western Yunnan, identified as Ascomycetes, Hypomycetes, and the fungus Ascomycetes Hypomyces (Fr) Tul.sp of the genus Mycoparasites for solid-state fermentation. The total amount of perylenequinone compounds is very low, and there is a great distance from practical application

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  • Biologic synthesis of perylene quinone compound
  • Biologic synthesis of perylene quinone compound
  • Biologic synthesis of perylene quinone compound

Examples

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Embodiment Construction

[0063] See the examples below.

[0064] The fungus Ascomycetes Hypomyces(Fr)Tul.sp, which grows in the mountainous area of ​​western Yunnan, is identified as Ascomycetes, Hypomycetes, and mycoparasites after collection. The slant medium was potato juice dextrose agar medium. The seed medium was 20 grams of glucose, 1 gram of KH per liter of potato juice 2 PO 4 , 0.5 g MgSO 4 .7H 2 O, 0.1 g CaCl 2 .2H 2 O, 10 mg Vitamin B 1 , adjusted to PH=6 with 0.1M NaOH, and sterilized at 120° C. for 30 minutes in a sterilizing pot. The solid base medium is m (corn flour): m (wheat bran): m (okara): 1:1:1, 1‰ peptone, adding appropriate amount of bagasse, the ratio of material to water is 10:3, and sterilized.

[0065] Seed culture: Add 150 ml of seed culture medium to a 500 ml Erlenmeyer flask, sterilize with steam at 120°C for 30 minutes, insert the strain after cooling, and place on a compound shaker at 120 rpm at a constant temperature of 26°C Shake continuously for 4 days to o...

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Abstract

Biosynthesis of quinine compound and its optimizational ferment process. Strain is Ascomycetes Hypomyces(Fr) Tul.sp. Solid medium contains maize flour, wheat bran and bean dregs. Strain is switched in the medium after disinfection. Ferment at 24-25deg.C above 7 days. Fungus containing quinine compound is obtained. Break and dry the fungus, then extract to obtain the product.

Description

technical field [0001] The invention belongs to the biocatalytic synthesis technology of compounds, specifically the biosynthesis method of perylenequinone compounds, and particularly relates to the optimization of the fermentation process in the biosynthesis process. Background technique [0002] Perylenequinone compounds, such as coelomycin, hypocrellin A, hypocrellin B, etc., are a class of phytochromes distributed in nature. In recent years, it has been found that they have good photosensitivity to kill tumor cells and inhibit AIDS virus HIV-1, and are also used to treat skin diseases. Perylenequinone compounds are also potential new photoelectric conversion materials. The research on perylenequinone compounds as emerging photosensitive active pesticides is attracting the attention of scientists. Different species of fungi in nature can produce secondary metabolites containing the skeleton of perylenequinone compounds. Since the natural resources are very limited, som...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P7/26C12P7/00C12R1/645
Inventor 李聪陈远腾台虹欧灵澄荷严萍
Owner YUNNAN UNIV
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