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Preparation process of strontium nano calcium phosphate containing biological active bone cement

A calcium phosphate biological and preparation technology, which is applied in the field of preparation of strontium-containing hydroxyapatite bone repair materials, can solve the problems of unsuitable human bone repair, achieve the effect of improving degradability and prolonging the therapeutic effect

Inactive Publication Date: 2007-01-03
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In 2001, French scholars (L.Lerous, J.L.Lacout.Preparation of calcium strontiumhydroxyapatites by a new route involving calcium phosphate cements.J.Mater.Res.2001, 16(1):171~178) firstly used the method of preparing calcium phosphate bone cement. Methods The strontium-containing hydroxyapatite was synthesized, and the solid phase powder used was Ca 4 (PO 4 ) 2 O and α-Ca 3 (PO 4 ) 2 , the liquid phase is Sr(NO 3 ) 2 with H 3 PO 4 Aqueous solution, but the disadvantage is that the final cured product contains a large amount of NO which is harmful to human tissue 3 - ions, not suitable for clinical applications such as human bone repair, follow-up research on mechanical properties and similar content have not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: 0.6g cement mixed powder and 0.4g concentration are the H of 1mol / l 3 PO 4The aqueous solution (where x=0.5, that is, Sr / (Sr+Ca)=5%; the solid / liquid mass ratio is 1.5:1) is mixed with a spatula for 30 seconds to form a uniform cement slurry, and the filling diameter is 6mm and the height is Put the 12mm stainless steel cylinder mold and apply a pressure of 0.7MPa for compaction, insert the resulting cylinder sample into a glass tube with a diameter of 6.5mm and a height of 13mm, and then put it into a glass tube with a temperature of 37°C and a relative humidity of 100%. After curing for 15 minutes, the sample is taken out and quickly immersed in SBF (simulated body fluid), and the SBF is replaced every 3 days. After 2 weeks, the final product that forms a cured body is strontium-containing calcium-deficient hydroxyapatite. (Ca 9.5 Sr 0.5 (PO 4 ) 6.69 2OH, Ca / P=1.49). The average compressive strength of the sample soaked in SBF for 1 day was 53.16MP...

Embodiment 2

[0013] Embodiment 2: 0.6g cement mixed powder and 0.24g concentration are the H of 0.5mol / l 3 PO 4 The aqueous solution (where x=0.5, that is, Sr / (Sr+Ca)=5%; the solid / liquid mass ratio is 2.5:1) is mixed with a spatula for 30 seconds to form a uniform cement slurry, and the filling diameter is 6mm and the height is Put the 12mm stainless steel cylinder mold and apply a pressure of 0.7MPa for compaction, insert the resulting cylinder sample into a glass tube with a diameter of 6.5mm and a height of 13mm, and then put it into a glass tube with a temperature of 37°C and a relative humidity of 100%. After curing for 15 minutes, the sample was taken out and quickly immersed in SBF, and the SBF was replaced every 3 days. After 2 weeks, the final product composed of strontium-containing calcium-deficient hydroxyapatite (Ca 9.5 Sr 0.5 (PO 4 ) 6.21 2OH, Ca / P=1.61). The average compressive strength of the sample soaked in SBF for 1 day was 51.55MPa, and the maximum compressive str...

Embodiment 3

[0014] Embodiment 3: 0.6g cement mixed powder and 0.3g concentration are the H of 0.5mol / l 3 PO 4 The aqueous solution (where x=0.5, that is, Sr / (Sr+Ca)=5%; the solid / liquid mass ratio is 2.0:1) is mixed with a spatula for 30 seconds to form a uniform cement slurry, and the filling diameter is 6mm and the height is Put the 12mm stainless steel cylinder mold and apply a pressure of 0.7MPa for compaction, insert the resulting cylinder sample into a glass tube with a diameter of 6.5mm and a height of 13mm, and then put it into a glass tube with a temperature of 37°C and a relative humidity of 100%. After curing for 15 minutes, the sample was taken out and quickly immersed in SBF, and the SBF was replaced every 3 days. After 2 weeks, the final product composed of strontium-containing calcium-deficient hydroxyapatite (Ca 9.5 Sr 0.5 (PO 4 ) 6.26 2OH, Ca / P=1.60). The average compressive strength of the sample soaked in SBF for 1 day was 45.12MPa, and the maximum compressive stre...

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Abstract

The invention discloses a preparing technique of special pharmacological strontium sustained-release and no-toxicity strontium-containing nano calcium phosphate bioactive cement. It adopts the cement solid phase: the mixed powder of Ca4(PO4)2O, CaHPO4 and SrHPO4 distributed at a certain particle size and prepared in a certain mole ratio and the liquid phase: H3PO4 solution at 0.5-1 mol / l, where the solid-liquid ratio is 1.5-3.0. On physiological conditions, and the final condensate product is strontium-containing acalcerosis hydroxyl phosphorite with a microscopic daisy-petal or bent-stick shaped nano crystal structure. This cement not only has higher mechanical and operable properties, but also sustainedly releases strontium ions with special pharmacological functions, and the result of preliminary cell toxicity test shows it has no toxicity. It has wider application prospect than traditional calcium phosphate cement.

Description

technical field [0001] The invention relates to a preparation technology of strontium-containing nano-calcium phosphate bioactive cement, in particular to a preparation technology of a strontium-containing hydroxyapatite bone repair material with slow release of special pharmacological strontium element and no toxic and side effects. Background technique [0002] Calcium Phosphate Cement (CPC) has a porous structure and the cured product is hydroxyapatite, which has good biocompatibility and osteoconductivity, and can be processed into a slurry form and directly injected into bone defects. In situ solidification, thus widely used in dental bone replacement, orthodontic and reconstructive surgery. Calcium phosphate bone cement is mainly composed of two parts: calcium phosphate powder and curing liquid. The solidification solution is generally water or dilute phosphoric acid aqueous solution, and the calcium phosphate powder mainly includes tetracalcium phosphate (Ca 4 (PO ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61F2/28C01B25/32
Inventor 郭大刚徐可为憨勇
Owner XI AN JIAOTONG UNIV
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