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Lavage preservation solution for pulmonary transplantation

A technology of preservation solution and lavage solution, which is applied in the field of lavage solution, can solve problems such as lung supply operation, surgical arrangement restrictions, and lung transplantation development obstacles, so as to prevent cell edema, facilitate popularization and application, and supply drug sources enough effect

Inactive Publication Date: 2006-05-17
陈静瑜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, LPD (low-potassium dextran) has been used as a lavage solution, and several reports have shown that its lung preservation effect is better than that of Euro-Collins solution and UW (University of Wisconsin) solution, and it is believed that it can better protect alveolar capillaries. Endothelial cells, but even so, are still not an ideal lavage fluid that can be widely used clinically. These factors lead to severe restrictions on the operation of lung donors, surgical arrangements, and even surgical operations, which have become an important obstacle to the development of lung transplantation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The lavage fluid contains potassium 3.5 (mmol / L), sodium 140 (mmol / L), magnesium 1.2 (mmol / L), chlorine 100 (mmol / L), phosphate 30 (mmol / L) ), sulfate 3.5 (mmol / L), prostaglandin E1 110 (mg / L), raffinose 30 (mmol / L), low molecular dextran 4030 (g / L), glutathione 4 (mmol / L), adenosine 6 (mmol / L), allopurinol 2 (mmol / L), dexamethasone 8 (mg / L).

Embodiment 2

[0027] The lavage fluid contains potassium 5.0 (mmol / L), sodium 130 (mmol / L), magnesium 1.2 (mmol / L), chlorine 110 (mmol / L), phosphate 40 (mmol / L) ), sulfate 4.5 (mmol / L), prostaglandin E1 150 (mg / L), raffinose 50 (mmol / L), low molecular dextran 40 20 (g / L), glutathione 5 (mL) mol / L), adenosine 8 (mmol / L), allopurinol 3 (mmol / L), dexamethasone 10 (mg / L).

Embodiment 3

[0029] The lavage fluid contains potassium 6.0 (mmol / L), sodium 150 (mmol / L), magnesium 2.5 (mmol / L), chlorine 108 (mmol / L), phosphate 38 (mmol / L) ), sulfate 5.5 (mmol / L), prostaglandin E1 130 (mg / L), raffinose 35 (mmol / L), low molecular dextran 4025 (g / L), glutathione 3.5 (mmol / L), adenosine 7 (mmol / L), allopurinol 1.5 (mmol / L), dexamethasone 9 (mg / L).

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Abstract

A lavage preservation solution for lung transplantation relates to an organ transplantation technique. According to the scheme provided by the present invention, the lavage fluid contains potassium 3.0-6 mmol / liter, sodium 130-168 mmol / liter, magnesium 1.0-2.5 mmol / liter, chlorine 100-110 mmol / liter, Phosphate 30-40 mmol / L, sulfate 3.5-5.5 mmol / L, prostaglandin E1 108-150 mg / L, raffinose 30-50 mmol / L, low molecular dextran 40 20-38 g / L Lift. The lavage solution can prolong the preservation time of transplanted organs, improve the survival rate of transplanted organs, and preserve the functions of transplanted organs to the greatest extent possible.

Description

technical field [0001] The invention relates to an organ transplantation technique, in particular to a lavage solution for lavaging organs to facilitate preservation and improve survival rate. Background technique [0002] Organ transplantation is called "the pinnacle of 21st century medicine". When entering the new century, organ transplantation has entered a new period of vigorous development. According to statistics from the Worldwide Transplant Center Directory (WTCD), so far more than 600,000 patients with incurable diseases have gained a second life through organ transplantation. After organ transplantation, they are healthy and live the same life as normal people; they are mentally healthy and energetic at work; women of childbearing age can conceive and give birth, and children can grow up healthily. In order to have a better prospect for organ transplantation, scientists from various countries are tirelessly exploring new fields. In order to develop the source of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N1/02
Inventor 陈静瑜
Owner 陈静瑜
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