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Chinese medicine preparation for treating hepatitis and its preparing and detecting method

A method of determination and hepatitis technology, applied in the field of preparation of the drug, can solve the problems of side effects, expensive medicine, etc.

Active Publication Date: 2006-04-26
LUNAN HOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are not many cases of this kind of drugs in the treatment of chronic hepatitis, the curative effect is yet to be confirmed, the drug costs are relatively expensive, and there are side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] Baicalin 66.7 parts by weight Honeysuckle extract (calculated as chlorogenic acid) 13.3 parts by weight

[0105] 10.7 parts by weight of gardenia extract, 20 parts by weight of capillary extract

[0106] Grind honeysuckle extract, gardenia extract, baicalin, capillary extract, add appropriate amount of sucrose powder and dextrin, mix well, add appropriate amount of ethanol, granulate, and dry to obtain.

[0107] Content determination:

[0108] (1) Determination method of baicalin:

[0109] Chromatographic Conditions and System Suitability Test Using Octadecyl Bonded Silica Gel as Filling Material

[0110] Use methanol-water-phosphoric acid in the ratio of 47:53:0.2 as the mobile phase

[0111] Detection wavelength 280nm

[0112] Preparation of Reference Substance Solution Accurately weigh about 10 mg of baicalin dried to constant weight, put it in a 10 ml measuring bottle, add methanol to dissolve and dilute to the mark, shake well, and obtain;

[0113] Preparation...

Embodiment 2

[0132] 40 parts by weight of baicalin, 20 parts by weight of honeysuckle extract (calculated as chlorogenic acid)

[0133] 15 parts by weight of gardenia extract and 30 parts by weight of capillary extract.

[0134] Grind honeysuckle extract, gardenia extract, baicalin, capillary extract, add appropriate amount of sucrose powder and dextrin, mix well, add appropriate amount of ethanol, granulate, and dry to obtain the product;

[0135] Content determination:

[0136] (1) Determination method of baicalin:

[0137] Chromatographic Conditions and System Suitability Test Using Octadecyl Bonded Silica Gel as Filling Material

[0138] Use methanol-water-phosphoric acid in the ratio of 47:53:0.2 as the mobile phase

[0139] Detection wavelength 280nm

[0140] Preparation of Reference Substance Solution Accurately weigh about 10 mg of baicalin dried to constant weight, put it in a 10 ml measuring bottle, add methanol to dissolve and dilute to the mark, shake well, and obtain;

[...

Embodiment 3

[0160] 90 parts by weight of baicalin, 6 parts by weight of honeysuckle extract (calculated as chlorogenic acid)

[0161] 15 parts by weight of gardenia extract and 30 parts by weight of capillary extract.

[0162] Grind honeysuckle extract, gardenia extract, baicalin, capillary extract, add lactose and sweetener in appropriate amount, mix well, dry granulate, pack, and get ready;

[0163] The content determination method is the same as above:

[0164] Measurement results: Each gram of granule contains: baicalin 200mg, contains: chlorogenic acid 4mg, contains: geniposide 5mg.

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Abstract

The invention discloses a new traditional Chinese medicine preparation for treating hepatitis and a preparation method thereof, which uses baicalin, honeysuckle extract, gardenia extract and capillary extract as raw materials, and is prepared after being treated by different physical or chemical methods Formed solid dosage form. The invention has a unique formula and is clinically effective in treating hepatitis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation for treating hepatitis, specifically a Chinese patent medicine prepared from Chinese medicinal materials as raw materials, and also relates to a preparation method of the medicine. Background technique [0002] Hepatitis is a common disease worldwide, and my country is an epidemic "hardest hit area", and various types of hepatitis seriously threaten the health of Chinese people. Hepatitis C is the most common in western countries, while hepatitis B is prevalent in my country. It is predicted that there are more than 100 million people who are positive for surface antigen in my country, that is, those who are infected with hepatitis B, and there are about 30 million patients with abnormal liver function caused by hepatitis B. In addition, chronic viral hepatitis is also closely related to the occurrence of primary liver cancer, and most patients with liver cancer have a history of chro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/744A61K9/14A61K9/20A61K9/48A61P1/16A61P31/12G01N30/02G01N33/15
Inventor 赵志全
Owner LUNAN HOPE PHARM CO LTD
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