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Treatment and diagnosis of cancer

A cancer cell and cancer tissue technology, applied in chemical instruments and methods, methods based on microorganisms, biochemical equipment and methods, etc., can solve problems such as limited therapeutic use

Inactive Publication Date: 2000-02-16
CORNELL RES FOUNDATION INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the therapeutic use of the 7E11 antibody is limited because it can only be effectively targeted to cells that have died or tissues that contain a large proportion of dead cells

Method used

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  • Treatment and diagnosis of cancer
  • Treatment and diagnosis of cancer
  • Treatment and diagnosis of cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Embodiment 1

[0102] Embodiment Example 1--human tissue

[0103] Fresh samples of benign and malignant tissue were obtained from the Department of Pathology at New York Hospital Cornel Univrsity Medical Center ("NYH-CUMC"). Embodiment 2--tissue culture

Embodiment 2

[0104] Cultured cell lines of human cancers were obtained from the Uro-Oncology Laboratory at NYH-CUMC. The prostate cancer cell line PC-3 was obtained from the American Type Culture Collection (Rockville, MD) (Mickey, D.D. et al., "Human prostate adenocarcinoma cell line in athymic mice as monolayer cultures and as solid tumors ( DU145), "Prog. Clin. Biol. Res., 37:67-84 (1980), which is incorporated herein by reference), DU145 (Mickey, D.D. et al.," as a monolayer in athymic mice Culture and characterization of a human prostate adenocarcinoma cell line (DU145) as a solid tumor," Prog. Clin. Biol. Res., 37: 67-84 (1980), which is incorporated herein by reference) and LNCaP (Horoszewiez , J.S. et al., "The LNCaP Model of Human Prostate Cancer," Cancer Res., 43: 1809-1818 (1983), which is incorporated herein by reference). Initially in RPMI- Hybridomas were cloned in 1640 medium. Subclones were grown in the same medium without aminopterin. Embodiment 3--Preparation of mouse...

Embodiment 3

[0104] Cultured cell lines of human cancers were obtained from the Uro-Oncology Laboratory at NYH-CUMC. The prostate cancer cell line PC-3 was obtained from the American Type Culture Collection (Rockville, MD) (Mickey, D.D. et al., "Human prostate adenocarcinoma cell line in athymic mice as monolayer cultures and as solid tumors ( DU145), "Prog. Clin. Biol. Res., 37:67-84 (1980), which is incorporated herein by reference), DU145 (Mickey, D.D. et al.," as a monolayer in athymic mice Culture and characterization of a human prostate adenocarcinoma cell line (DU145) as a solid tumor," Prog. Clin. Biol. Res., 37: 67-84 (1980), which is incorporated herein by reference) and LNCaP (Horoszewiez , J.S. et al., "The LNCaP Model of Human Prostate Cancer," Cancer Res., 43: 1809-1818 (1983), which is incorporated herein by reference). Initially in RPMI- Hybridomas were cloned in 1640 medium. Subclones were grown in the same medium without aminopterin. Embodiment 3--Preparation of mouse...

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Abstract

The present invention is directed to the use of antibodies or binding portions thereof, probes, ligands, or other biological agents which either recognize an extracellular domain of prostate specific membrane antigen or bind to and are internalized with prostate specific membrane antigen. These biological agents can be labeled and used for detection of cancerous tissues, particularly cancerous tissues proximate to or containing vascular endothelial cells, which express an extracellular domain of prostate specific membrane antigen. The labeled biological agents can also be used to detect normal, benign hyperplastic, and cancerous prostate epithelial cells or portions thereof. They also can be used alone or bound to a substance effective to ablate or kill such cells as a therapy for prostate or other cancers. Also disclosed are four hybridoma cell lines, each of which produces a monoclonal antibody recognizing extracellular domains of prostate specific membrane antigens of normal, benign hyperplastic, and cancerous prostate epithelial cells or portions thereof.

Description

[0001] This application claims the benefit of U.S. Provisional Patent Application Serial No. 60 / 022,125, filed July 18, 1996, and is a continuation-in-part of U.S. Patent Application Serial No. 08 / 838,682, filed April 9, 1997, Serial No. 08 / US Patent Application No. 838,682 claims the benefit of US Provisional Patent Application Serial No. 60 / 016,976, filed May 6,1996. field of invention [0002] The present invention relates to the treatment and diagnosis of cancer with biological drugs. Background of the invention [0003] Despite improvements in treatment for some types of cancer, it remains the leading cause of death in the United States. Since early diagnosis greatly increases the chances of a complete remission of the cancer in most cases, it is highly desirable for doctors to be able to detect cancer before a solid tumor develops. However, the development of methods that can rapidly and accurately detect many types of cancer...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/53A61K38/00A61K39/395A61K45/00A61P35/00C07K16/28C07K16/30C12N15/09C12P21/08C12Q1/02C12R1/91G01N33/574
CPCY10S435/81Y10S435/975G01N33/57434C07K2317/77G01N2333/705A61K2039/505C07K16/3069A61P35/00A61P35/04
Inventor N·H·邦德
Owner CORNELL RES FOUNDATION INC
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