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Complex external medicine for treating acne

A technology for external use of drugs and compound prescriptions, which is applied in the directions of drug combination, drug delivery, and medical preparations containing active ingredients, etc., can solve the problems of storage conditions, shelf life and convenience of use, unstable quality, and fluctuation of curative effect, etc., and achieve curative effect. Satisfactory, strong receptor selectivity, less skin irritation

Inactive Publication Date: 2005-07-13
CHINA RESOURCES SANJIU MEDICAL & PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The main problem with unilateral therapy is that it has a single effect and can only target 1-2 disease links at most (such as antibacterial plus anti-inflammatory, or antibacterial plus anti-angular suppository)
In addition, most of the above-mentioned acne keratolytic drugs have local irritation and / or allergic effects, and benzoyl peroxide has a strong oxidative effect. If they are composed of compound preparations, the quality is not easy to stabilize, which will cause fluctuations in the concentration and curative effect of compatible drugs. Storage conditions, shelf life and use Convenience and other aspects are greatly affected

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The effective active ingredients of this embodiment adopt tazarotene 0.1% (percentage by weight, the same below) and clindamycin hydrochloride (or phosphoric acid) 1%, and the base carrier adopts cetyl alcohol, vaseline, liquid paraffin, monostearic acid Glycerides, glycerin, solubilizers, emulsifiers, ethylparaben and distilled water.

Embodiment 2

[0020] The effective active ingredients of this example are tazarotene 0.05% and erythromycin 2%, and the matrix carrier is cetyl alcohol, vaseline, liquid paraffin, glycerol monostearate, glycerin, solubilizer, emulsifier, hydroxybenzene Ethyl esters and distilled water.

Embodiment 3

[0022] First, the two effective active ingredients and 0.1% of ethyl hydroxybenzoate in Example 1 or Example 2 are dissolved in the solubilizer; Vaseline, 8-12% of the total amount of liquid paraffin, 5-10% of the total amount of glyceryl monostearate and an appropriate amount of emulsifier are mixed and heated to 80-85°C; Mix distilled water and heat to 80-85°C, and emulsify it with the mixture of cetyl alcohol, vaseline, liquid paraffin, glycerol monostearate and emulsifier; leave the emulsified mixture from the heat source, stir and cool to 65°C At the same time, a solubilizer containing two effective active ingredients and ethyl paraben is added, and stirred evenly to form a cream.

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PUM

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Abstract

The invention relates to a compound external medicine for treating acne. It is characterized in that: the matrix carrier of the compound external drug contains the following two effective active ingredients (weight percentage): 0.01-2% of tazarotene, and 0.25-5% of antibacterial drugs; the effective active ingredient contained in the compound external drug After mixing with a base carrier, it forms a cream or gel or a liniment or film. The advantage of the present invention is that: the present invention contains two main components of retinoic acid and antibacterial for treating acne in the form of a compound preparation, so as to simultaneously exert three (and above) curative effects (dissolving horn plugs, regulating keratinization, Antimicrobial, anti-inflammation, secondary factors to reduce sebum secretion, etc.), played a complementary and synergistic effect in pharmacology.

Description

Technical field: [0001] The invention relates to a medicine for external use for treating acne, in particular to a compound medicine for external use for treating acne. Background technique: [0002] Acne is a chronic disease of the sebaceous glands. It can be divided into inflammatory and non-inflammatory acne. It is the second most common disease in dermatology. The incidence rate accounts for about 7-10% of skin diseases. The age of the disease covers 11-30 years old, men and women Anyone can suffer. [0003] It is now known that the following four pathogenic factors and links play a key role in the occurrence, development and outcome of acne: 1. The microbial action in the hair follicle and sebaceous unit, first is the anaerobic Propionibacterium acnes, and the second is the aerobic bacteria Predominant pyogenic bacteria such as epidermis and Staphylococcus aureus, it is believed that Saccharomyces is also involved in the pathogenesis; 2, androgen and sebaceous gland hy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K9/06A61K9/70A61K31/4436A61K31/496A61K31/5383A61K31/65A61K31/7028A61K31/7048A61P17/10
Inventor 郑家润张崇璞李新宇陈沄高纪伟唐美育徐兰芳
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
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