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Glioma marker group and application thereof

A glioma and tumor marker technology, applied in biochemical equipment and methods, microbial determination/inspection, instruments, etc., can solve the problem of insufficient application of glioma, and achieve strong subjectivity and time-consuming Effect

Pending Publication Date: 2022-08-05
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Claims
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AI Technical Summary

Problems solved by technology

[0005] Although the gene is closely related to the occurrence and development of tumors or gliomas, it is not fully used in the identification, molecular typing, malignant grading and prognosis assessment of gliomas
Among them, ISL2, OSR2, TNFRSF11B, CABP4, CCDC18, IQGAP2, EFNB1, OTP, COL4A2, HIST1H3H, SERPINA5, PLSCR1, IGF2BP2, CEP135, HOXD10, LAMA2, ARAP3, GLA, FNDC3B, PYGL, PIGY, BCAN, CD68, CPXM1, SOX4 , MDFI, CCDC80, TIMP4, TREM2, TCF12, MASP1, SRPX and other genes in the identification, molecular typing, malignant grading and prognosis evaluation of glioma have not been reported in the literature
However, the combination of two or more genes of said genes has not been reported for the identification, molecular typing, malignant grading and prognosis evaluation of gliomas.

Method used

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  • Glioma marker group and application thereof
  • Glioma marker group and application thereof
  • Glioma marker group and application thereof

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Embodiment 1

[0033] In the present invention, we take glioma as the object of implementation. In the present invention, we use RNA Sequencing technology to analyze the difference of mRNA expression in glioma and normal brain tissue; and the relationship between these differences and the identification, molecular typing, malignant grading and prognosis of glioma, etc. For example. The WHO (histological) classification of gliomas includes: glioblastoma multiforme (GBM, WHO IV), lower grade gliomas (WHO II, WHOIII). Based on The Cancer Genome Atlas (TCGA) database research, we analyzed the difference in gene expression between glioma tissue and normal brain tissue, the relationship between gene expression profile and malignancy, and the relationship between gene expression difference and glial To investigate the relationship between tumor prognosis, we screened out a group of genes that are closely related to glioma identification, molecular typing, malignant grading and prognosis; including...

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Abstract

The invention belongs to the field of biological and medical examination, and relates to a group of tumor markers for glioma identification, molecular typing, malignant grading and prognosis evaluation and application thereof. The related genes comprise ISL2, OSR2, TNFRSF11B, CABP4, CCDC18, IQGAP2, EFNB1, OTP, COL4A2, HIST1H3H, SERPINA5, PLSCR1, IGF2BP2, CEP135, HOXD10, LAMA2, ARAP3, GLA, FNDC3B, PYGL, PIGY, BCAN, CD68, CPXM1, SOX4, MDFI, CCDC80, TIMP4, TREM2, TCF12, MASP1, SRPX, UBE2C, MS4A6A, C1QC, PDPN, ANXA2, WEE1, HIST1H2BJ, ANG, EN1, ZNF217 The expression quantity difference of products (protein and RNA) of the gene (single gene or any combination) can be used for predicting the existence of glioma, molecular typing, targeted drug screening, malignant grade and the total lifetime of a patient. When the optimal combination of the markers is used for identifying normal brain tissues and glioma, the sensitivity can reach 97% or above when the specificity is greater than 99%. The marker can be directly applied and can also be combined with WHO pathological grading, 1p19q mutation state and the like.

Description

technical field [0001] The invention belongs to the field of biological and medical testing, and relates to a group of tumor markers and applications for glioma identification, molecular typing, malignant grading and prognosis evaluation; the involved genes include: ISL2, OSR2, TNFRSF11B, CABP4, CCDC18, IQGAP2, EFNB1, OTP, COL4A2, HIST1H3H, SERPINA5, PLSCR1, IGF2BP2, CEP135, HOXD10, LAMA2, ARAP3, GLA, FNDC3B, PYGL, PIGY, BCAN, CD68, CPXM1, SOX4, MDFI, CCDC80, TIMP4, TREM2, 44 genes including TCF12, MASP1, SRPX, UBE2C, MS4A6A, C1QC, PDPN, ANXA2, WEE1, HIST1H2BJ, ANG, EN1, ZNF217, EMILIN3, TMEM100, etc. The marker includes the gene product (protein, RNA), and predicts the existence of glioma by using the close relationship between the change of the gene expression and the carcinogenesis of glial tissue, the grade of malignancy and the prognosis of the patient. Molecular typing, targeted drug screening, malignancy grade and overall survival of patients. Background technique ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G01N33/574
CPCC12Q1/6886G01N33/57496G01N33/57488G01N33/57407C12Q2600/112C12Q2600/118C12Q2600/136C12Q2600/158
Inventor 刘春芳马展
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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