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Additive for adjusting heart function of animal in high altitude area

A heart function, high-altitude technology, applied to the determination/test of microorganisms, drug combination, cardiovascular system diseases, etc., can solve the problems of antioxidant capacity, inflammatory factors, and energy metabolism that have not been reported in the literature.

Pending Publication Date: 2022-08-05
QINGHAI UNIVERSITY
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  • Abstract
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  • Claims
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Problems solved by technology

The effects of cichoric acid on the antioxidant capacity, inflammatory factors and energy metabolism of H9c2 rat cardiomyocytes under hypoxia induction have not been reported in the literature
[0004] Through the above analysis, the existing problems and defects of the prior art are: the influence of cichoric acid on the antioxidant capacity, inflammatory factors and energy metabolism of H9c2 rat cardiomyocytes under the induction of hypoxia has not been reported in the literature

Method used

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  • Additive for adjusting heart function of animal in high altitude area
  • Additive for adjusting heart function of animal in high altitude area
  • Additive for adjusting heart function of animal in high altitude area

Examples

Experimental program
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Effect test

Embodiment

[0047] Example: Effects of cichoric acid on the level of oxidative damage, inflammatory factors and energy metabolism in H9c2 rat cardiomyocytes induced by hypoxia

[0048] 1. The purpose of the present invention is to investigate the effect of Chicoric acid (CA) on the level of oxidative damage, inflammatory factors and energy metabolism of H9c2 rat cardiomyocytes under hypoxia induction. This test takes H9c2 rat cardiomyocytes as the research object. H9c2 rat cardiomyocytes were seeded on 96-well plates and divided into control group (normoxia group), normoxia + cichoric acid (60 μg / ml) group, hypoxia group (1% oxygen concentration) and hypoxia (1% oxygen concentration) group. Oxygen concentration) + cichoric acid group (60 μg / ml), three replicates were set for each group, the first four groups were pretreated for 24 h to make the cells adhere and grow to a suitable cell density, and the control group and the normoxia + cichoric acid group were compared put CO 2 In the incu...

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Abstract

The invention belongs to the technical field of additives, and discloses an additive for regulating the heart function of animals in high-altitude areas, and the effective component of the additive for regulating the heart function of animals in high-altitude areas is echinacea extract-chicoric acid; the content of chicoric acid is 4%, and the chicoric acid is yellow green fine powder and comprises 2-2.2% of chicoric acid, 1-1.5% of caffeic acid, 0.5-1% of chlorogenic acid and 0.3-0.5% of echinacea glycoside; the method for verifying the chicoric acid as the additive for regulating the heart functions of the animals in the high-altitude areas comprises the following steps: preparing a reagent; carrying out cell culture and grouping; determining oxidative damage level related enzyme activity; related inflammatory factor indexes are measured; determining related indexes of energy metabolism; and carrying out data processing. Results show that the chicoric acid improves the oxidation resistance of myocardial cells of H9c2 rats under hypoxia induction, reduces secretion of inflammatory factors and increases the energy metabolism rate.

Description

technical field [0001] The invention belongs to the technical field of additives, and in particular relates to an additive for regulating the heart function of animals in high altitude areas. Background technique [0002] At present, oxygen is an essential substance to maintain the survival of humans and animals. It can be used as an electron acceptor to participate in the synthesis of ATP and provide energy for life activities. Hypoxia refers to lower than normal levels of oxygen in the body under certain physiological / pathological conditions. When the body is stimulated by the external hypoxic environment, it will have a series of non-specific responses in order to adapt to the environment, which is called hypoxic stress. This is the most essential feature of life, and it is common in the process of biological evolution. Various biochemical reactions in mammalian cells must be carried out smoothly in sufficient oxygen concentrations. Long-term exposure of the body to a ...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61K31/7048A61P9/00C12Q1/02A61K31/192
CPCA61K31/216A61K31/192A61K31/7048A61P9/00G01N33/5044C12N2503/02G01N2500/10A61K2300/00
Inventor 吴华陈鑫磊行倩文沈童
Owner QINGHAI UNIVERSITY
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