Research method of panaxadiol

A technology of panaxadiol and ginseng is applied in the research field of (20R)-panaxadiol, which can solve the problems of low solubility and bioavailability, and narrow therapeutic indications.

Pending Publication Date: 2022-07-22
JILIN UNIV
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  • Description
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Problems solved by technology

The ginseng monomer currently used in clinical practice is ginsenoside Rg3, which is mainly used in the treatment of tumor patients, but its solubility and bioavailability are low, and its treatment indications are narrow

Method used

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  • Research method of panaxadiol
  • Research method of panaxadiol
  • Research method of panaxadiol

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Embodiment Construction

[0067] In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention, but not to limit the present invention.

[0068] The specific implementation of the present invention will be described in detail below with reference to specific embodiments.

[0069] In one embodiment, a research method for Panaxadiol, see Figure 1 to Figure 22 , including the research steps of (20R)-panaxadiol:

[0070] Step 1: Explore the material basis, targets and pathways of ginseng for anti-obesity and its complications through network pharmacology

[0071] Step 2: Study the effect and mechanism of (20R)-panaxadiol on lipid-lowering and weight-loss in high-fat-fed mice;

[0072] Step 3: Experimental study on the relati...

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Abstract

The invention discloses a research method of panoxadiol, and belongs to the technical field of research of (20R)-panoxadiol, and the technical key point is that the research method comprises the research steps of (20R)-panoxadiol: step 1, excavating material basis, target spots and pathways of ginseng for resisting obesity and complications thereof through network pharmacology; 2, studying the lipid-lowering and weight-losing curative effect and mechanism of the (20R)-panoxadiol on the high-fat fed mouse; 3, researching the relationship between the inhibition of (20R)-panoxadiol on fat cell hypertrophy and the cAMP / PKA pathway through experiments; 4, (20R)-panoxadiol is used for researching the lipid-lowering and weight-losing mechanism of ob / ob obese mice by regulating and controlling a beta2 / cAMP / PKA pathway; 5, observing the efficacy of (20R)-panoxadiol for preventing and treating non-alcoholic fatty liver of high-fat induced obese mice and ob / ob obese mice, and primarily probing the mechanism of the (20R)-panoxadiol; and step 6, analyzing and researching the intestinal flora and metabolites thereof to prevent and treat obesity and complications thereof through a non-absorption way by the (20R)-panoxadiol.

Description

technical field [0001] The invention relates to the research field of (20R)-panaxadiol, in particular to a research method of panaxadiol. Background technique [0002] Obesity is a chronic nutritional metabolic disease caused by the combined influence of congenital genetic factors and acquired environmental factors. With the growth of my country's economy and the improvement of people's living standards, high-fat and high-calorie eating habits and lack of exercise have increased the proportion of overweight people, and the obesity problem has become increasingly serious, affecting people's physical and mental health and seriously reducing the quality of life. According to reports, there are currently about 500 million obese people with pre-diabetes. Obesity is one of the important reasons for endangering human health. The diseases caused by obesity can be said to be all over the body, but especially metabolic diseases such as diabetes, hyperlipidemia Obesity, nonalcoholic f...

Claims

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Application Information

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IPC IPC(8): G16C20/50G16B25/00G16H70/40A61K31/58A61K36/258A61P3/04A61P3/06A61P3/10A61P1/16
CPCG16C20/50G16B25/00G16H70/40A61K31/58A61K36/258A61P3/04A61P3/06A61P3/10A61P1/16
Inventor 关凤英陈立张明吕玉清凤渐舒
Owner JILIN UNIV
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