Continuous flow reactor with controllable residence time and design and use method thereof

Abstract

The invention provides a continuous flow reactor with controllable retention time and a design and use method thereof. The continuous flow reactor comprises a rotating shaft and n cavity channels which are fixedly arranged around the rotating shaft and are connected end to end. Combination of a centrifugal force field and a micro (milli) channel is achieved. The transmission interface is expanded through the structural design of the micro-channel; under the action of a centrifugal force field, vortex can be generated in the channel when the net flow velocity is relatively low or even zero, so that a relatively good mixing effect is realized; by designing the channel structure, the residence time in the channel can be controlled; through simple longitudinal stacking and series connection, continuous flow can be easily realized. The reactor has a particularly obvious treatment effect on high-viscosity materials.

Description

technical field [0001] The invention belongs to the technical field of microchannel reactors and rotating equipment, and in particular relates to a continuous flow reactor with controllable residence time and a design and use method thereof. Background technique [0002] The traditional batch kettle production method has shortcomings such as low mass transfer and heat transfer efficiency, poor product quality stability, and low production efficiency. The continuous flow reactor can solve this problem very well. In recent years, continuous flow reactors have been widely used in chemical, pharmaceutical, new materials and other fields. Research on continuous flow reactors mainly focuses on microchannel reactors, but there are still some shortcomings and improvements in continuous flow microchannel reactors at this stage: [0003] For example, Chinese patent CN215611613U pointed out that the mixing effect of continuous flow reactor is poor at low flow rate (the fluid in the c...

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Problems solved by technology

[0003] For example, Chinese patent CN215611613U points out that the continuous flow reactor has poor mixing effect under the condition of low flow rate (the fluid in the channel is laminar flow at low flow rate, and the vortex phenomenon is not obvious); although the mixing effect is good under the condition of high flow rate, the reactants The residence time in the pipeline is short, which cannot meet the requirement of reaction time, resulting in the problem of low reaction efficiency

[0004] The published paper (Zhao Chenxi, T-type microchannel device preparation of monodisperse chitosan microspheres and its in vitro drug release performance. Beijing University of Chemical Technology) pointed out: there are high viscosity, high pressure in the microchannel, and different flow patterns in the channel. Stable, and easy to cause problems such as wear and tear on equipment

[0005] In addition, in the current continuous flow microchannel reactor, the viscosity of the material in the microchannel only stays at the mPa·s level, and there are few researches and achievements on high-viscosity and ultra-high-viscosity materials.

[0006] In terms of structure, conventional microchannel reactors are mainly coiled tubes, but the length of coiled tubes required for continuous operation is extremely large and the cost is high

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