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Anti-adhesion membrane for promoting nerve repair and preparation method thereof

An anti-adhesion film and nerve repair technology, which is applied in the field of medical materials, can solve the problems of different anti-adhesion film matching, anti-adhesion film hardening and brittleness, etc., to achieve wound healing, prevent adhesion, and simple and easy preparation method Effect

Pending Publication Date: 2022-07-15
CHANGCHUN SINOBIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned method in the prior art tends to make the anti-adhesion film hard and brittle after the drug is loaded; moreover, the loaded drug is generally an anti-inflammatory drug, and the composition structure of different drugs is different, and the combination with the anti-adhesion film And the matching is different, not any drug can be well combined with the anti-adhesion film and give full play to the medicinal effect. At present, there is no relevant report on adding drugs that promote nerve growth to the degradable anti-adhesion film

Method used

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  • Anti-adhesion membrane for promoting nerve repair and preparation method thereof
  • Anti-adhesion membrane for promoting nerve repair and preparation method thereof
  • Anti-adhesion membrane for promoting nerve repair and preparation method thereof

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preparation example Construction

[0037] The invention provides a preparation method for promoting nerve repairing anti-adhesion film, comprising the following steps:

[0038] a) dissolving the degradable polymer and the drug in the organic solvent A to obtain a precursor solution;

[0039] or

[0040] Dissolving the degradable polymer-drug conjugate in organic solvent A to obtain a precursor solution;

[0041] b) coating the precursor solution on the bottom plate to form a film, and forming a wet film on the bottom plate;

[0042] c) immersing the bottom plate with wet film obtained in step b) in solvent B to remove organic solvent A, and drying to obtain an anti-adhesion film;

[0043] in:

[0044] The organic solvent A is selected from one or more of N,N-dimethylformamide, N,N-dimethylacetamide, N-methylpyrrolidone and 1,4-dioxane;

[0045] Described solvent B is water, or is the mixture of water and organic solvent A;

[0046] The drug is a drug for promoting nerve repair.

[0047]In the preparation ...

Embodiment 1

[0072] 1. Preparation

[0073] Weigh 0.5g of PLGA-PEG copolymer (the number average molecular weight is 100,000, and the mass ratio of PEG structural fragments is 5%) and 25mg of drug RAPA were dissolved in 2mL of N,N-dimethylacetamide, and stirred evenly After that, the precursor solution was obtained. Set the parameters of the flat film scraper: the film thickness is 0.05mm, and the blade speed is 1m / min. Pour the above precursor solution on the glass plate and turn on the equipment to scrape the film, then quickly immerse the glass plate in excess deionized water, replace the deionized water after half an hour, and repeat the above operation until the organic solvent in the anti-adhesion film is completely removed . Finally, the formed film was taken out from the glass plate and dried at room temperature to obtain a drug-loaded anti-adhesion film.

[0074] 2. Characterization

[0075] Scanning electron microscope (SEM) observation was performed on the upper surface, cro...

Embodiment 2

[0089] 1. Preparation

[0090] Weigh 0.002g of PLA-PEG copolymer (the number average molecular weight is 250,000, and the mass ratio of PEG structural fragments is 10%) and 400mg of drug RAPA were dissolved in 2mL of N,N-dimethylacetamide and 1,4 - in a mixed solvent of dioxane (volume ratio of 1:3), after stirring uniformly, a precursor solution is obtained. Set the parameters of the flat film scraper: the film thickness is 1mm, and the blade speed is 0.1m / min. Pour the above precursor solution on the glass plate and turn on the equipment to scrape the film, then quickly immerse the glass plate in excess deionized water, replace the deionized water after half an hour, and repeat the above operation until the organic solvent in the anti-adhesion film is completely removed . Finally, the formed film was taken out from the glass plate and dried at room temperature to obtain a drug-loaded anti-adhesion film.

[0091] 2. Characterization

[0092] According to the characterizat...

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Abstract

The invention provides an anti-adhesion membrane for promoting neural restoration and a preparation method of the anti-adhesion membrane. The preparation method provided by the invention comprises the following steps: a) dissolving a degradable polymer and a drug or a degradable polymer-drug bonded substance in an organic solvent A to obtain a precursor solution; b) coating the precursor solution on a bottom plate to form a film, and forming a wet film on the bottom plate; and c) immersing the base plate with the wet film obtained in the step b) into a solvent B to remove the organic solvent A, and drying to obtain the anti-adhesion film, wherein the organic solvent A is selected from one or more of N, N-dimethyl formamide, N, N-dimethyl acetamide, N-methyl pyrrolidone and 1, 4-dioxane, and the organic solvent B is selected from one or more of N, N-dimethyl formamide, N, N-dimethyl acetamide, N-methyl pyrrolidone and 1, 4-dioxane; the solvent B is water or a mixture of water and the organic solvent A; the medicine is a medicine for promoting neural restoration. The obtained anti-adhesion membrane can effectively prevent adhesion between surrounding tissues and nerves, promote growth and repair of nerve cells and tissues, and ensure mechanical properties.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to an anti-adhesion film for promoting nerve repair and a preparation method thereof. Background technique [0002] For the complete or partial rupture of the peripheral nerve caused by various reasons, and the defect can be overcome to get close to the broken end, the method of nerve suture is mainly used in clinical treatment. However, the proliferation of scar tissue at the nerve anastomosis and its adhesion to the surrounding tissue will not only affect the local microcirculation, but also hinder the extension of the regenerated axons to the distal end, resulting in disordered nerve microscopic arrangement and hindering nerve function. The complete recovery of nerve cells will ultimately directly affect the effect of nerve regeneration and functional recovery. Therefore, how to solve the hyperplasia and adhesion in the process of peripheral nerve repair is an urgent problem to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/14A61L31/16
CPCA61L31/06A61L31/14A61L31/146A61L31/16A61L2300/412A61L2300/602A61L2300/216C08L71/02
Inventor 王迪于越王晋岳
Owner CHANGCHUN SINOBIOMATERIALS
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