Application of Remetinostat in preparation of medicine for treating psoriasis

A psoriasis and drug technology, applied in the field of pharmacy, can solve the problems of unsatisfactory treatment effect, increase the living burden of patients, and limit the use of large amounts, and achieve the effects of clear toxicology and pharmacology, great promotion and application value, and convenient use

Pending Publication Date: 2022-07-15
XIANGYA HOSPITAL CENT SOUTH UNIV
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of dithranol, tar preparations, and glucocorticoids is limited due to side effects; the therapeutic effects of retinoic acid, calcineurin inhibitors, and vitamin DR derivatives are not very satisfactory, and biological agents such as monoclonal antibodies are expensive , increase the burden of life of patients

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of Remetinostat in preparation of medicine for treating psoriasis
  • Application of Remetinostat in preparation of medicine for treating psoriasis
  • Application of Remetinostat in preparation of medicine for treating psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Gel for external use in the treatment of psoriasis, prepared from 0.1 part of Remetinostat, 0.5 part of carbomer, 5 parts of propylene glycol, 802 parts of polysorbate, 0.65 part of triethanolamine, 0.5 part of ethylparaben, and 91.25 parts of water made. The preparation method includes the following steps: dissolving Remetinostat in a mixed solution of water, propylene glycol, polysorbate 80, triethanolamine and ethylparaben to obtain solution 1. The carbomer is mixed with an appropriate amount of water, stirred and swollen overnight to obtain a gel matrix. The solution 1 was added to the gel base and stirred well to obtain a 0.1% Remetinostat topical gel.

Embodiment 2

[0034] External gel for the treatment of psoriasis, prepared from 0.5 parts of Remetinostat, 0.5 parts of carbomer, 5 parts of propylene glycol, 802 parts of polysorbate, 0.65 parts of triethanolamine, 0.5 parts of ethylparaben, and 90.85 parts of water made. The preparation method includes the following steps: dissolving Remetinostat in a mixed solution of water, propylene glycol, polysorbate 80, triethanolamine and ethylparaben to obtain solution 2. The carbomer is mixed with an appropriate amount of water, stirred and swollen overnight to obtain a gel matrix. The solution 2 was added to the gel base and stirred well to obtain a 0.5% Remetinostat topical gel.

Embodiment 3

[0036] The external ointment for treating psoriasis is prepared from 0.1 part of Remetinostat, 1 part of propylene carbonate, 1 part of propylene glycol, 75.9 parts of white petrolatum, 20 parts of liquid paraffin and 2 parts of lanolin. The preparation method includes the following steps: dissolving Remetinostat in a mixed solution of propylene carbonate and propylene glycol to obtain solution 3. White petrolatum, liquid paraffin, and lanolin were heated to 65° C. (melted base), solution 3 was slowly added to the melted base, and stirred until naturally cooled to obtain 0.1% Remetinostat topical ointment.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the field of pharmacy, and particularly relates to application of Remetinostat in preparation of a medicine for treating psoriasis. According to the application of Remetinostat in preparation of the medicine for treating psoriasis, Remetinostat and an external gel matrix or an external ointment matrix are prepared into external gel or external ointment for treating psoriasis, skin lesion, cuticle thickening and expression of interferon (INF-gamma) can be relieved, and the medicine is more convenient to use, smaller in toxic and side effects and higher in curative effect. A new way is provided for effectively treating the psoriasis.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the application of Remetinostat in the preparation of a medicine for treating psoriasis. Background technique [0002] Psoriasis is a common chronic inflammatory skin disease, and its histopathological changes are mainly manifested as hyperproliferation of keratinocytes and parakeratosis, significant thickening of the spinous layer, accompanied by inflammatory cells such as lymphocytes and histiocytes. infiltration. Psoriasis has an incidence of 0.1%-2.9% in the natural population and affects about 2% of the global population. There are about 6 million psoriasis patients in my country, and the number is increasing year by year. The etiology of psoriasis is complex, the course of disease is long, and it is easy to recur, which seriously affects the physical and mental health and quality of life of patients. [0003] At present, there are many drugs for the treatment of psoriasis vulgari...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/235A61K9/06A61K47/32A61K47/44A61P17/06
CPCA61K31/235A61K9/0014A61K9/06A61K47/32A61K47/44A61P17/06
Inventor 陈翔周星辰刘洪蒋骞陈旺青梁小伟
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap