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Preparation method of hydroxybutyl chitosan-gelatin composite gel artificial blood vessel coating

A technology of hydroxybutyl chitosan and composite gel, which is applied in coating, anticoagulant treatment, packaging food, etc., can solve the problems of blood compatibility that is difficult to match and cannot meet the requirements, so as to promote wound healing. Healing, promotion of cell adhesion and growth, good biocompatibility

Pending Publication Date: 2022-07-12
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a preparation method of hydroxybutyl chitosan-gelatin composite gel artificial blood vessel coating, which solves the problem that existing medical blood catheter materials are difficult to match with blood compatibility and cannot meet the requirements The problem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation method of a hydroxybutyl chitosan-gelatin composite gel artificial blood vessel coating of the present invention is specifically implemented according to the following steps:

[0020] Step 1, first dissolve chitosan in HCl solution with a concentration of 1%, and filter out insoluble matter; then slowly add NaOH solution with a concentration of 1% to the filtrate while stirring, until the flocs are no longer generated. increase; finally collect the precipitate, wash the precipitate with distilled water to neutrality, and then wash the precipitate with ethanol to complete desalination and dehydration, and then freeze-dry at -60 °C;

[0021] Weigh 2g of purified chitosan and disperse it in 20ml of NaOH solution with a concentration of 50%, stir at room temperature for 24h to make it fully alkalized, then filter to remove excess lye, then add isopropanol and stir for 24h to alkalize the shell The polysaccharide was completely dispersed in 40ml isopropanol s...

Embodiment 2

[0024] The preparation method of a hydroxybutyl chitosan-gelatin composite gel artificial blood vessel coating of the present invention is specifically implemented according to the following steps:

[0025] Step 1, first dissolve chitosan in HCl solution with a concentration of 1.2%, and filter out the insoluble matter; then slowly add NaOH solution with a concentration of 1.2% to the filtrate while stirring until the flocs are no longer generated. increase; finally collect the precipitate, wash the precipitate with distilled water to neutrality, then wash the precipitate with ethanol to complete desalination and dehydration, and then freeze-dry at -63 °C;

[0026] Weigh 2.5g of purified chitosan and disperse it in 23ml of NaOH solution with a concentration of 53%, stir at room temperature for 25h to make it fully alkalized, then filter to remove excess lye, then add isopropanol and stir for 25h to make alkalization Chitosan was completely dispersed in 43ml of isopropanol syst...

Embodiment 3

[0029] The preparation method of a hydroxybutyl chitosan-gelatin composite gel artificial blood vessel coating of the present invention is specifically implemented according to the following steps:

[0030] Step 1, first dissolve chitosan in HCl solution with a concentration of 1.5%, and filter out insoluble matter; then slowly add NaOH solution with a concentration of 1.5% to the filtrate while stirring until the flocs are no longer generated. increase; finally collect the precipitate, wash the precipitate with distilled water to neutrality, and then wash the precipitate with ethanol to complete desalination and dehydration, and then freeze-dry at -65 °C;

[0031] Weigh 3g of purified chitosan and disperse it in 25ml of NaOH solution with a concentration of 55%, stir at room temperature for 26h to make it fully alkalized, then filter to remove excess lye, then add isopropanol and stir for 26h to alkalize the shell Polysaccharides were completely dispersed in 45ml isopropanol ...

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PUM

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Abstract

The invention discloses a preparation method of a hydroxybutyl chitosan-gelatin composite gel artificial blood vessel coating, which is specifically implemented according to the following steps: step 1, preparing hydroxybutyl chitosan by taking chitosan as a raw material; 2, the hydroxybutyl chitosan prepared in the step 1 is compounded with gelatin, and the hydroxybutyl chitosan-gelatin composite gel artificial blood vessel coating is obtained. According to the preparation method of the hydroxybutyl chitosan-gelatin composite gel artificial blood vessel coating, the problems that a material for an existing medical blood catheter is difficult to adapt to blood compatibility and cannot meet requirements are solved.

Description

technical field [0001] The invention belongs to the technical field of biomedical material preparation, in particular to a preparation method of a hydroxybutyl chitosan-gelatin composite gel artificial blood vessel coating. Background technique [0002] Cardiovascular disease is one of the most serious diseases threatening human beings in the world today, and its morbidity and mortality have surpassed tumor diseases and ranked first. The survey and analysis data of the cause of death in my country also show that 40% of the deaths in recent years are due to cardiovascular diseases. As vascular disease is the leading cause of human death, the use of artificial blood vessels is increasing. Scholars at home and abroad first selected materials with good blood compatibility from existing materials to prepare medical blood catheters, such as polyurethane, polyetheramine, polyethylene, polyvinyl chloride, polystyrene, polyvinyl alcohol, Polytetrafluoroethylene, polyphthalamide, po...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/48A61L27/50A61L27/52A61L33/00A61L33/08C08B37/08
CPCC08B37/003A61L27/507A61L27/34A61L27/52A61L27/48A61L33/08A61L33/0041A61L33/0064A61L2300/236A61L2300/404A61L2300/412A61L2300/41A61L2300/42C08L89/00C08L5/08
Inventor 焦森李仁杰刘新华林鹭沈冰洁毛楷文
Owner SHAANXI UNIV OF SCI & TECH
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