Traditional Chinese medicine composition for treating myelodysplastic syndrome as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention relates to a traditional Chinese medicine composition for treating myelodysplastic syndrome as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 1-3 parts of realgar, 100-300 parts of semen cuscutae, 100-300 parts of glossy privet fruit and 100-300 parts of radix pseudostellariae. The traditional Chinese medicine composition is reasonable in compatibility, the semen cuscutae, the glossy privet fruit and the radix pseudostellariae have the effects of strengthening body resistance and tonifying deficiency, and aim at the body resistance and deficiency essence of myelotoxin and fatigue; the realgar'combats poison with poison 'and directly attacks'myeloid poison' superficial pathogenesis, and the four medicines supplement each other, have the effects of tonifying spleen, tonifying kidney and detoxifying, jointly play the curative effects of strengthening healthy qi and removing stasis poison ', and highly accord with the traditional Chinese medicine pathogenesis connotation of'vital qi deficiency and stasis poison' of MDS patients. The MDS cell proliferation inhibition effect is in direct proportion to the concentration and time of the important composition. According to the present invention, by promoting the hMOF to promote the acetylation of histone H4K16, the autophagy of MDS cells can be enhanced, the oxidative stress level can be reduced, such that the cell proliferation can be inhibited, the cell apoptosis can be induced, and the further conversion of MDS to AML can be prevented so as to provide the anti-tumor effect, provide the prevention and treatment effect in MDS, and be suitable for clinical promotion and use.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for treating myelodysplastic syndromes, and a preparation method and application thereof. Background technique [0002] Myelodysplastic syndromes (MDS) are a group of heterogeneous myeloid clonal diseases originating from hematopoietic stem cells. Functional failure, high risk of transformation to acute myelogenous leukemia (AML). Traditional Chinese medicine treatment focuses on "strengthening the body and eliminating pathogenic factors, attacking and replenishing the balance". On the basis of focusing on the main disease and the main syndrome, it actively prevents and treats related complications, improves the clinical efficacy and quality of life, restores the functional state of the body, reduces the cost of treatment, and more patients benefit. [0003] Chinese patent document CN102319338A disclos...

AI Technical Summary

Problems solved by technology

But a kind of Chinese medicine composition for the treatment of myelodysplastic syndrome of the present invention and its preparation method and application have not yet been reported

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