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Emulsion for skin barrier repair and preparation method thereof

A skin barrier and lotion technology, applied in the field of skin care products, to achieve the effects of improving barrier function, reducing loss and increasing moisture content

Pending Publication Date: 2022-06-10
深圳市皖吉瑞生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main method to restore the skin barrier function is to use moisturizers. Currently, skin moisturizers mainly include oil-blocking moisturizers, hydrophilic matrix moisture-absorbing moisturizers, and hydration moisturizers. However, simple moisturizing cannot fundamentally solve the problem of damaged skin barrier function. Repair after damage

Method used

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  • Emulsion for skin barrier repair and preparation method thereof
  • Emulsion for skin barrier repair and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 3

[0027] The preparation process of the staghorn fern extract is as follows: take the staghorn fern and grind it to 100 mesh after drying, add 80% ethanol solution with a solid-liquid ratio of 1:15, and ultrasonically extract for 20 minutes at a temperature of 70°C and a power of 150W. , and then kept at 70° C. for 30 minutes, filtered through a 0.45 μm filter membrane, and the filtrate was obtained, and freeze-dried to obtain a freeze-dried powder for future use.

[0028] The bitter melon extract is commercially available.

[0029] A preparation method for emulsion for repairing skin barrier, comprising the following steps:

[0030] Comparative example 1

[0031] Comparative example 2

[0032] Comparative example 3

[0033] Comparative example 4

Embodiment 2

[0035] Comparative example 6

[0036] Safety test: A total of 30 subjects, all female, aged between 25 and 45, were randomly divided into 3 groups, 10 people in each group, for patch test. Take about 0.03-0.04g of the products of Examples 1 to 3 and place them in the spot test device, stick them on the back of the subject with medical tape, remove them after 24 hours, and observe the skin at 0.5 hours, 24 hours and 48 hours after removal Reaction, according to the skin reaction record results in the "Safety and Technical Specifications for Cosmetics", the standard is shown in Table 1.

[0037] Table 1

[0038] Skin moisture content and skin water loss (TEWL) test: 70 subjects aged 25-45 were selected, and the facial skin had different degrees of skin barrier damage, and the facial skin appeared dry, erythema, and desquamated and other symptoms, the above-mentioned symptoms were diagnosed as being caused by other skin diseases. The above-mentioned subjects were randomly divi...

Embodiment 3

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PUM

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Abstract

The invention discloses an emulsion for repairing a skin barrier. The emulsion is prepared from the following raw materials in parts by weight: 3-9 parts of a soothing and repairing composition, 10-15 parts of a humectant, 1-5 parts of an emulsifier, 0.5-1 part of a thickening agent, 0.1-0.3 part of a preservative, 0.02-0.05 part of essence and 50-60 parts of deionized water, the soothing and repairing composition is prepared from a platycladus orientalis extract, a bitter gourd extract and asiaticoside according to the weight ratio of 1: (0.3-0.6): (0.5-0.8). The emulsion provided by the invention is added with the repairing composition consisting of the chonemorpha prolifera extract, the balsam pear extract and the asiaticoside, so that on one hand, the emulsion has a soothing effect, is mild to skin and avoids bringing new stimulation to barrier damaged skin; on the other hand, the moisture content of the skin can be increased, the loss of transdermal moisture is reduced, then the symptoms of dryness, sensitivity, redness and the like of the facial skin are improved, and the barrier function of the skin is improved through the synergistic effect of the three components. The invention further provides a preparation method of the emulsion for skin barrier repair, the process is simple and convenient, operation is easy, and a guarantee is provided for commercialization of products.

Description

technical field [0001] The invention relates to the field of skin care products, in particular to an emulsion for skin barrier repair and a preparation method thereof. Background technique [0002] The skin is the first line of defense of the human body. The outermost layer of the skin is called the stratum corneum, which is composed of flat hexagonal corneocytes about 30 μm wide and 0.8 μm thick. Generally, there are 10-20 layers of cells and a thickness of 10-15 μm. The uppermost layer of the epidermis also has a double layer of lipids to form a sebum film, which is a protective film formed by the mixture of sweat and sebum, which together constitute the skin's barrier. The skin barrier can lock skin moisture and oil, and resist the invasion of various skin surface bacteria, which plays a very important role in protecting human health. [0003] Under the influence of changes in the external environment, such as cold, dry, and harsh environmental problems such as smog and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/9749A61K8/60A61Q19/00
CPCA61K8/9789A61K8/9749A61K8/602A61Q19/00A61Q19/007A61Q19/005A61K2800/82A61K2800/84A61K2800/5922
Inventor 段钦迎丁勇
Owner 深圳市皖吉瑞生物医药科技有限公司
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