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Application of alginate oligosaccharide in preparation of product for preventing and/or treating intestinal mucosa O-carbohydrate chain structure abnormity diseases caused by inflammation

A technology of algin oligosaccharides and intestinal mucosa, which is applied in the direction of oligosaccharide-containing food ingredients, applications, and functions of food ingredients, etc., can solve the problems of no algin oligosaccharides, etc., and improve intestinal mucosa The effect of reduction, abundant resources, and easy industrialization

Pending Publication Date: 2022-06-07
OCEAN UNIV OF CHINA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Alginate oligosaccharides are prepared from alginate, and there are no related reports on the application of alginate oligosaccharides in the protection of intestinal mucosal O-sugar chains

Method used

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  • Application of alginate oligosaccharide in preparation of product for preventing and/or treating intestinal mucosa O-carbohydrate chain structure abnormity diseases caused by inflammation
  • Application of alginate oligosaccharide in preparation of product for preventing and/or treating intestinal mucosa O-carbohydrate chain structure abnormity diseases caused by inflammation
  • Application of alginate oligosaccharide in preparation of product for preventing and/or treating intestinal mucosa O-carbohydrate chain structure abnormity diseases caused by inflammation

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experiment example 1

[0043] (1) Preparation of oligomeric guluronic acid and oligomeric mannuronic acid:

[0044]Prepare sodium alginate as a 10wt% aqueous solution, heat it to 85°C with 1wt% dilute hydrochloric acid, stir and degrade it for 4.5 hours, neutralize it with 10wt% sodium carbonate aqueous solution after cooling, then adjust the pH to 3.65 with 5wt% dilute hydrochloric acid, and centrifuge Serum A was used for the preparation of oligomeric mannuronic acid (LMM), and precipitate B was used for the preparation of oligomeric guluronic acid (LMG). The supernatant A part containing oligomannuronic acid was adjusted to pH 1 with 5wt% dilute hydrochloric acid, the precipitate was collected after centrifugation, dissolved with 2mol / L NaOH to adjust the pH to 7, and 3 times the volume of 95wt% ethanol was added to collect the precipitate , dehydrated with absolute ethanol and dried to obtain LMM. Part B of the precipitate containing oligomeric guluronic acid was dissolved with 2 mol / L NaOH to ...

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Abstract

The invention belongs to the technical field of marine drug development, and provides application of alginate oligosaccharide in preparation of products for preventing and / or treating intestinal mucosa O-sugar chain structure abnormity diseases caused by inflammation. A mouse model with enteritis intestinal mucosa injury, which is molded by adding DSS into drinking water, proves that the algin oligosaccharide can obviously improve the reduction of intestinal mucosa goblet cells of the mouse with enteritis intestinal mucosa injury; the algin oligosaccharide is also proved to be capable of remarkably improving intestinal mucosa O-carbohydrate chain composition ratio imbalance, short-chain O-carbohydrate chain content increase and long-chain O-carbohydrate chain content reduction of intestinal mucosa mice with enteritis intestinal mucosa injury. The raw materials of the product provided by the invention are derived from marine brown algae polysaccharide, and the product has the advantages of abundant resources, simple preparation process, good product stability, easy industrialization, high safety and the like, and has wide development and application prospects in the development field of new drugs and special medical foods for preventing and treating intestinal mucosa O-carbohydrate chain structure abnormality related diseases caused by enteritis.

Description

technical field [0001] The invention relates to the technical field of marine drug development, in particular to the application of alginate oligosaccharides in the preparation of products for the prevention and / or treatment of intestinal mucosal O-sugar chain structural abnormalities caused by inflammation. Background technique [0002] The intestinal barrier is a physical barrier mainly composed of epithelial cells, immune cells, secretory cells and their secreted mucus layer. The colonic mucus layer is mainly composed of glycoproteins rich in O-sugar chains secreted by goblet cells. Under normal physiological conditions, the intestinal mucosa can selectively absorb water and nutrients and effectively prevent pathogens, toxins, and allergens from diffusing from the lumen to other tissues, organs, and blood. However, when the intestinal tract is inflamed and the intestinal mucosa is damaged, microorganisms and endotoxins can cross the intestinal mucosal barrier, leading to...

Claims

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Application Information

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IPC IPC(8): A61K31/702A61P29/00A61P1/00A61P1/18A23L33/125
CPCA61K31/702A61P29/00A61P1/00A61P1/18A23L33/125A23V2002/00A23V2200/32A23V2250/28Y02A50/30
Inventor 于广利潘琳尚庆森李国云
Owner OCEAN UNIV OF CHINA
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