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Compound with anti-neurodegenerative change activity as well as preparation method and application thereof

A neurodegenerative and compound technology, applied in the field of medicine, can solve the problems of long growth cycle, lack of resources, difficulty in obtaining raw materials, etc., and achieve the effect of good protection.

Active Publication Date: 2022-06-03
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, drugs for anti-neurodegenerative changes are mainly extracted and separated from natural products such as animal and plant medicines. The growth cycle is long and the raw materials are difficult to obtain. At the same time, the demand for a large number of raw materials may easily lead to resource scarcity or even exhaustion to varying degrees.
In addition, due to differences in production areas and animal and plant drugs that occur in different seasons, the active secondary metabolite components and contents are quite different, making it difficult to reproduce the active ingredients

Method used

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  • Compound with anti-neurodegenerative change activity as well as preparation method and application thereof
  • Compound with anti-neurodegenerative change activity as well as preparation method and application thereof
  • Compound with anti-neurodegenerative change activity as well as preparation method and application thereof

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Embodiment Construction

[0042] In order to make the purpose, technical solutions and advantages of the present application more clear, the present application will be further described in detail below with reference to the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application, but not to limit the present application. The reagents not described in detail and individually in this application are all conventional reagents and can be obtained from commercial sources; the methods not described in detail are all conventional experimental methods, which can be known from the prior art.

[0043] Preparation of compounds represented by formula I\formula II

[0044] 1. Strain

[0045] The compounds represented by formula I or formula II disclosed in the examples of this application are obtained by fermenting and culturing fungi to extract and separate their secondary metabolites.

[0046] The bacterial species involved in the e...

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Abstract

The invention discloses a compound with anti-neurodegenerative change activity and a preparation method and application thereof. The compound with anti-neurodegenerative change activity can be produced by adopting a co-culture mode of two strains of alternaria brassicae and penicillium, and the capacity of microorganisms for synthesizing secondary metabolites is excavated as much as possible by virtue of research methods of changing a culture medium, culture conditions, a mixed culture ratio and the like. And scale-up culture can be carried out on the basis of repeatable and sustainable development of the process. The compound has neuroprotective activity on neurodegenerative change disease cells, and shows a better protective effect than a positive drug tert-butylhydroquinone (TBHQ).

Description

technical field [0001] The present application relates to the field of medical technology, in particular to compounds with anti-neurodegeneration activity, preparation methods and applications thereof. Background technique [0002] Neurodegenerative diseases are caused by the loss of neurons and / or their myelin sheaths, which worsen and become dysfunctional over time. Neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, affect many people worldwide, and the severity and severity of their symptoms have a dramatic impact on the quality of life of patients and their families. [0003] Clinical treatment of neurodegenerative diseases mainly includes surgery and chemotherapy. Surgical therapy has a high recurrence rate of postoperative disease, thus limiting its widespread use in the treatment of neurodegenerative diseases. In terms of drug treatment of neurodegenerative diseases, the existing drugs for Alzheimer's disease can only delay the deepening of pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/93C07C49/755C07C45/78C07C45/79C07C45/80A61P25/28C12P17/04C12P7/38A61K31/365A61K31/122C12R1/80C12R1/645
CPCC07D307/93C07C49/755C07C45/78C07C45/79C07C45/80A61P25/28C12P17/04C12P7/38C07B2200/07C07C2603/36Y02A50/30
Inventor 胡琳珍童周孔璐琦胡天卉盘诗湘汪钰钏孙娜
Owner HUBEI UNIV
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