Disodium adenosine triphosphate external medicine for preventing and treating myopia as well as preparation method and application of disodium adenosine triphosphate external medicine

A technology of disodium adenosine triphosphate and external medicine, which is applied in the field of medicine, can solve the problems of non-application and side effects of disodium adenosine triphosphate, and achieve the effects of avoiding side effects, dilating peripheral blood vessels, and reducing astigmatism

Pending Publication Date: 2022-06-03
裴丽林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, adenosine triphosphate disodium has obvious side effects when used by injection, and its application in the prevention and treatment of visual fatigue, myopia and myopic amblyopia has not yet appeared.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Disodium adenosine triphosphate eye drops for preventing and treating myopia, the eye drops are prepared from the following raw materials: 21.05g of adenosine triphosphate disodium, 30.30g of L-methionine, added to 80% water for injection with a total volume of 2000ml, Stir to dissolve completely, then adjust the pH value of the solution to 8.00 by using 30 ml of 4% aqueous sodium hydroxide solution, and add the remaining water for injection to the full amount. The milliosmolarity of the adenosine disodium triphosphate eye drops is 377.65 mosmol / Kg; the concentration of the adenosine disodium triphosphate eye drops in the eye drops is 0.011 g / ml; the pH value of the obtained adenosine triphosphate disodium eye drops is 8.00.

Embodiment 2

[0058] Disodium adenosine triphosphate eye drops for preventing and treating myopia, the eye drops are prepared from the following raw materials: 21.05 g of adenosine disodium triphosphate and 35.35 g of L-methionine, added to 80% water for injection with a total volume of 2000 ml, Stir until completely dissolved, then adjust the pH value of the solution to 9.00 by using 37.50 ml of a 4% aqueous sodium hydroxide solution, and add the remaining water for injection to the full amount. The milliosmolarity of the adenosine disodium triphosphate eye drops is 426.49 mosmol / Kg; the concentration of the adenosine disodium triphosphate eye drops in the eye drops is 0.011 g / ml; the pH value of the obtained adenosine triphosphate disodium eye drops is 9.00.

Embodiment 3

[0060] An external drug of adenosine triphosphate disodium for preventing and treating myopia, the external drug comprising the eye drops described in Embodiment 1-2 and the adenosine triphosphate disodium eye patch;

[0061] Described adenosine triphosphate disodium eye patch includes eye patch and eye patch spunlace non-woven fabric, and described eye patch is prepared from the following raw materials: 21.05g of adenosine triphosphate disodium, 30.30g of L-methionine, 4 % sodium hydroxide solution 30ml, water for injection was added to 3000ml. The milliosmolarity of the adenosine disodium triphosphate eye patch is 251.77 mosmol / Kg;

[0062] The concentration of adenosine disodium triphosphate in the eye patch is 0.007 g / ml; the pH value is adjusted to 7.85 with 30 ml of a 4% aqueous sodium hydroxide solution.

[0063] The eye patch consists of two spunlace non-woven fabrics, both of which are elliptical, with a transverse long axis diameter of 8.1 cm and a longitudinal shor...

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Abstract

The invention discloses an adenosine disodium triphosphate external medicine for preventing and treating myopia as well as a preparation method and application of the adenosine disodium triphosphate external medicine. The externally applied medicine comprises an adenosine disodium triphosphate eye drop and an adenosine disodium triphosphate eye patch, wherein the adenosine disodium triphosphate eye patch comprises an eye patch liquid and a spunlace non-woven fabric for the eye patch; the invention further discloses a medicine for preventing and treating myopia. The medicine comprises an oral medicine and an external medicine, the disodium adenosine triphosphate eye drop and the disodium adenosine triphosphate eye patch liquid both comprise disodium adenosine triphosphate, L-methionine and a pH regulator. According to the disodium adenosine triphosphate eye patch, the prevention and treatment effects of disodium adenosine triphosphate on eye asthenopia, myopia and myopic amblyopia are effectively exerted, and side effects caused in the use process are effectively avoided. According to the invention, a lengthened part of the ocular axis can be shortened, astigmatism of a crystalline lens can be removed or relieved, the distant vision of naked eyes can be improved, the functions of optic nerves and retina can be improved, and some asthenopia and systemic discomfort symptoms caused by myopia can be relieved.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an external application of adenosine triphosphate disodium for preventing and treating myopia and a preparation method and application thereof. Background technique [0002] Adenosine triphosphate disodium is a coenzyme drug. It is a nucleotide derivative and participates in the metabolism of fat, protein, sugar, nucleic acid and nucleotides in the body. Adenosine triphosphate disodium can also penetrate the blood and cerebrospinal fluid barrier and improve the nerve cell membrane structure. Stability and rebuilding ability, promoting the regrowth of neurites. It can synthesize nucleic acid under the action of enzymes in vivo with pentose, and synthesize cephalin and cytidine monophosphate with phospholipid cholamine under the action of transcytidase. Adenosine triphosphate (ATP) is an energy substance in the body. When energy is required for absorption, decomposition, muscle...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/70A61K47/18A61K31/7076A61P27/10A61P27/02
CPCA61K9/08A61K9/70A61K9/0048A61K47/183A61K31/7076A61P27/10A61P27/02
Inventor 裴丽林罗茜茜
Owner 裴丽林
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