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Application of parthenolide medicine in preparation of novel medicine for treating rhabdomyosarcoma

A kind of parthenolide, rhabdomyosarcoma technology, applied in the field of medicine

Pending Publication Date: 2022-05-17
JIAMUSI UNIVERSITY
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Many studies have proved that PTL has various anti-tumor effects such as blocking cell cycle, inhibiting epithelial-mesenchymal transition, inhibiting tumor cell migration and invasion, inducing tumor cell apoptosis and autophagy, inhibiting tumor angiogenesis and reversing multi-drug resistance. But there is no report about the application of parthenolide drugs in the preparation of drugs for the treatment of rhabdomyosarcoma

Method used

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  • Application of parthenolide medicine in preparation of novel medicine for treating rhabdomyosarcoma

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Experimental program
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Effect test

Embodiment Construction

[0011] The purpose of this experiment is to investigate the inhibitory effect of parthenolide on the proliferation of human rhabdomyosarcoma RD cell line (A204) in vitro.

[0012] 1. Experimental materials

[0013] Parthenolide drugs were purchased from Nanjing Chunqiu Biotechnology Co., Ltd.; human rhabdomyosarcoma A204 was purchased from ATCC, USA. Before the start of the experiment, the above-mentioned cells frozen in liquid nitrogen were revived according to the conventional method, and the suspension culture was placed at 37°C, 5% CO 2 In the high-glucose DMEM medium (supplemented main components include 10% fetal bovine serum, 100U / mL penicillin, 100μg / mL streptomycin and 2mmol / L L-glutamine) in the constant temperature cell culture box, every 2~ The medium was changed every 3 days and passaged once, and the cells in the logarithmic growth phase were taken for experiments.

[0014] 2. Experimental method

[0015] Tumor cells in the logarithmic growth phase were taken,...

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Abstract

The invention relates to application of parthenolide in preparation of a novel medicine for treating rhabdomyosarcoma, parthenolide is gemmarane type sesquiterpene lactone extracted and separated from plants such as wild chamomile and the like, and has biological activities such as anti-inflammatory activity, antibacterial activity and anti-tumor activity. According to the application of the medicine, an effective amount of parthenolide is given to rhabdomyosarcoma cells (A204), it is measured that the cell proliferation inhibition rate of the parthenolide reaches up to 97.34%, the parthenolide has huge application prospects in the aspect of rhabdomyosarcoma treatment, and a novel medicine application of parthenolide medicine in rhabdomyoma treatment is provided.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a novel drug application of parthenolide drug preparation for treating rhabdomyosarcoma. Background technique [0002] Rhabdomyosarcoma (rhabdomyosarcoma, RMS) originates from rhabdomyosarcoma or mesenchymal cells that differentiate into rhabdomyosarcoma, with an incidence of about 6 per million people worldwide every year. It is the most common soft tissue sarcoma in children, except for R0 resection margins In addition to wide resection, radiotherapy and chemotherapy are also very important means in the treatment of RMS. Although the survival of children has improved to some extent in the past three decades, the improvement of treatment quality and the treatment of recurrent RMS are still a problem that needs to be solved urgently. With the development of high-throughput sequencing and whole-genome sequencing technology, clues have been provided to the molecular biological me...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P35/00
CPCA61K31/365A61P35/00
Inventor 杜琛琛孙维彤白著双
Owner JIAMUSI UNIVERSITY
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