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Dopamine-embedded nano-selenium assembled compound and preparation method thereof

A technology of dopamine and nano-selenium, applied in the field of nanomaterials

Pending Publication Date: 2022-04-26
THIRD INST OF OCEANOGRAPHY MINIST OF NATURAL RESOURCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to improve the stability of nano-selenium in the liquid phase and facilitate the development of nano-selenium products that can be made into oral liquids, the present invention aims at the problems of easy aggregation of nano-selenium particles into blocks, stability in the liquid phase caused by light, and proposes Dopamine is used to polymerize and embed a single nano-selenium core to form a core-shell structure similar to "frog eggs", and at the same time achieve the following four purposes: (1) The dopamine layer completely covers the nano-selenium, which is not easy to fall off; (2) Nano-selenium particles Physical isolation and electrostatic repulsion dispersion; (3) reduce the impact of light on nano-selenium; (4) the dopamine layer is rich in modifiable chemical groups, which can be further functionalized

Method used

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  • Dopamine-embedded nano-selenium assembled compound and preparation method thereof
  • Dopamine-embedded nano-selenium assembled compound and preparation method thereof
  • Dopamine-embedded nano-selenium assembled compound and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0053] Dissolve 0.2g of fucoidan in 50mL of ultrapure water, add 10mL of ascorbic acid solution with a concentration of 0.1M, and after mixing thoroughly, gradually add 2mL of sodium selenite solution with a concentration of 0.1M, and stir quickly until the solution turns red. Deepen again. The reactant is centrifuged at a high speed, the centrifugation condition is 20000rcf×30min, the precipitate is collected, and the precipitate is resuspended and centrifuged with pure water, and the washed precipitate is resuspended in 5mL pure water to obtain fucoidan-nano selenium (F-SeNPs) sol. Add 0.5 mL of dopamine hydrochloride solution with a concentration of 0.05 g / mL to the F-SeNPs sol, and after stirring thoroughly, add 10 mL of Tris hydrochloric acid solution (0.1 M) to adjust the pH to 8.5-8.8, and quickly stir and react at room temperature in the dark for 24 hours. After the reaction was completed, the reactant was centrifuged at 20,000 rcf×30 min, the supernatant was discarde...

Embodiment 2

[0055] Dissolve 0.4g of i-carrageenan in 100mL of ultrapure water, add 2mmol of ascorbic acid, mix well, then gradually add 4mL of 0.1M sodium selenite solution, and stir quickly until the red color in the solution does not deepen. The reactant was centrifuged at a high speed under the condition of 20000rcf×30min, the precipitate was collected, and the precipitate was resuspended and centrifuged with pure water. After washing, the precipitate was resuspended in 10mL pure water to obtain i-carrageenan-nano Selenium (i-C-SeNPs) sol. 25 mg of dopamine hydrochloride was added to 5 mL of i-C-SeNPs sol, and after being fully stirred, the pH was adjusted to 9-10 with concentrated ammonia water, and the reaction was rapidly stirred at room temperature at 1000 rpm for 24 h in the dark. After the reaction was completed, the reactant was centrifuged at 20,000 rcf×30 min, the supernatant was discarded, and the black precipitate was collected together. The black precipitate was washed sev...

Embodiment 3

[0057] Take 4g / L of sodium alginate 20 (average molecular weight 20kDa) solution in 50mL of ultrapure water, add 1mmol of ascorbic acid, after mixing well, gradually add 2mL of 0.1M sodium selenite solution, stir rapidly React until the red color in the solution no longer deepens. The reactants were centrifuged at a high speed under the condition of 20000rcf×30min. The precipitate was collected and precipitated with pure water by resuspension and centrifugation. The washed precipitate was resuspended in 5mL pure water to obtain sodium alginate 20-nanometer Selenium (A20-SeNPs) sol. Add 20 mg of dopamine sulfate to 5 mL of A20-SeNPs sol, stir well, add 10 mL of ammonium persulfate solution with a concentration of 10 μg / mL, and quickly stir and react at room temperature in the dark for 24 h. After the reaction was completed, the reactant was centrifuged at 20,000 rcf×30 min, the supernatant was discarded, and the black precipitate was collected together. The black precipitate ...

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Abstract

The invention discloses a dopamine-embedded nano-selenium assembled compound and a preparation method thereof, the assembled compound comprises nano-selenium and dopamine, the dopamine is distributed on the surface of the nano-selenium to form a polymeric dopamine film, and a'frog egg 'core-shell structure is formed. According to the invention, complete coating of nano-selenium is achieved through a mononuclear'frog egg type 'core-shell structure, physical isolation between nano-selenium is realized, and a dopamine shell has relatively strong ultraviolet absorption capability, so that nano-selenium can be protected from being influenced by ultraviolet rays. The dopamine-embedded nano-selenium assembled compound disclosed by the invention can be used as a selenium source and is applied to occasions needing selenium supplementation; the nano-selenium-coated polydopamine shell can be used as a functional carrier, and can be further modified to prepare nano-materials or nano-drugs.

Description

technical field [0001] The invention belongs to the field of nanomaterials, relates to nanomedicine materials, in particular to a dopamine-embedded nano-selenium assembly compound with a core-shell structure and a preparation method thereof. Background technique [0002] Selenium is an essential micronutrient element for humans and animals. It has a wide range of biological activities and plays an important role in the prevention of cardiovascular diseases, anti-oxidation, anti-aging, anti-virus, anti-cancer, and immune function regulation. Selenium deficiency is closely related to dozens of common diseases. Reasonable supplementation of selenium and maintaining a reasonable metabolism of selenium in the body are crucial to maintaining the normal physiological functions of animals and humans. The development of innovative oral selenium supplements has a good effect on alleviating selenium deficiency. [0003] Compared with the traditional inorganic selenium and organic sel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K33/04A61K47/34A61P3/02A61P9/00A61P31/12A61P35/00A61P37/02A61P39/06B82Y5/00
CPCA61K33/04A61K9/5146A61P3/02A61P35/00A61P9/00A61P39/06A61P31/12A61P37/02B82Y5/00
Inventor 白锴凯洪碧红何建林
Owner THIRD INST OF OCEANOGRAPHY MINIST OF NATURAL RESOURCES
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