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Drug-loaded nanofiber for acupuncture point catgut embedding material as well as preparation method and application of drug-loaded nanofiber

A drug-loaded nano and fiber technology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve problems such as analgesic effectiveness and safety problems, and achieve prolonged drug release time, good application prospects, and excellent biocompatibility Effects on sex and spinnability

Active Publication Date: 2022-04-22
上海市第四人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005]Therefore, there is an urgent need to develop a compound catgut embedding material that can slowly release adenosine A1 receptor agonist for acupuncture points, simulating acupuncture plus catgut embedding The compound analgesic effect of the compound analgesic effect, in order to exert a synergistic effect, enhance the analgesic effect of adenosine A1 receptors and acupoints, and achieve relatively long-term acupoint stimulation, thereby achieving high-efficiency and long-term analgesia, and solving day surgery patients Analgesic Effectiveness and Safety Conundrums After Home Discharge

Method used

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  • Drug-loaded nanofiber for acupuncture point catgut embedding material as well as preparation method and application of drug-loaded nanofiber
  • Drug-loaded nanofiber for acupuncture point catgut embedding material as well as preparation method and application of drug-loaded nanofiber
  • Drug-loaded nanofiber for acupuncture point catgut embedding material as well as preparation method and application of drug-loaded nanofiber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Example 1: Preparation of three-layer coaxial drug-loaded nanofibers and embedding materials

[0077] 1.1 Polylactic acid (PLA) purification:

[0078] Add 30g of PLA pellets into 180mL of dichloromethane, stir to dissolve it completely, and then add 1080mL of ethanol to form a mixed solution. At room temperature (25±3° C.), vacuum filter the solution, pour it into a petri dish, and dry it at 30° C. to obtain purified PLA.

[0079] 1.2 Solution preparation:

[0080] 0.1 g of polylactic acid purified by 1.1 was added to 0.9 g of acetone solvent, and stirred at 70° C. for 12 h to obtain a uniform polylactic acid-acetone solution (PLA solution) with a mass fraction of 10%. Weighed 267.2 mg of adenosine and added it to 1 mL of dimethyl sulfoxide (DMSO), stirred at room temperature for 30 min to prepare a homogeneous solution with a concentration of 1 M, which was designated as adenosine solution A.

[0081] 1.3 Preparation of three-layer coaxial fiber and embedding materi...

Embodiment 2 3

[0084] Example 2. Preparation of three-layer coaxial drug-loaded nanofibers and embedding materials

[0085] Take the same polylactic acid-acetone solution (PLA solution) as in Example 1, weigh 347.4 mg of adenosine and dissolve it in 1 mL of DMSO to prepare a homogeneous solution with a concentration of 1.3 M, which is designated as adenosine solution B.

[0086] 800 μL of PLA solution and 200 μL of adenosine solution B were uniformly mixed as the spinning solution for the core layer and the middle layer, and other steps were consistent with the preparation method of step 1.3 in Example 1 to obtain the drug-loaded nanofiber membrane. The three layers of coaxial drug-loaded nanofibers that make up the drug-loaded nanofiber membrane have a general structure as figure 1 As shown, it includes a shell layer 1, an intermediate layer 2 and a core layer 3 in sequence from outside to inside, wherein both the core layer 3 and the intermediate layer 2 are drug-loaded layers.

[0087] T...

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Abstract

The invention provides a drug-loaded nanofiber which is of a multi-layer coaxial structure, and the multi-layer coaxial structure at least comprises a shell layer, a middle layer and a core layer from outside to inside; all the drug-loaded layers are arranged except the shell layer, and each drug-loaded layer is made of a mixture of an adenosine A1 receptor agonist and a biodegradable material; and the shell layer is made of a biodegradable material. The invention also provides a medical catgut embedding material which is composed of the drug-loaded nanofiber and can slowly release an adenosine A1 receptor stimulant. The invention also provides a method for preparing the drug-loaded nanofiber, and an application of the drug-loaded nanofiber or the medical catgut embedding material in preparation of a medical material for analgesia. After the drug-loaded nanofiber and the medical catgut embedding material are applied to acupuncture points, adenosine A1 receptor agonists can be slowly released, so that the purpose of long-acting analgesia is achieved.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a drug-loaded nanofiber, a medical thread-embedding material based on the drug-loaded nanofiber, a preparation method thereof, and a composite type of slow-release adenosine A1 receptor agonist for acupuncture points Application of embedding material in analgesic treatment. Background technique [0002] Day surgery is the main form of surgery in the future. Similar to other surgeries, postoperative pain is one of the most common symptoms after surgery. The incidence of acute postoperative pain was 91.8%, and about 86% of the surgical patients experienced moderate, severe or very severe pain. The management of pain after day surgery differs markedly from the management of pain after inpatient surgery. Day surgery patients are discharged home within 24 hours after surgery. If opioids are used as the main analgesic, respiratory depression, pruritus, nausea and vomiting, urinary r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/7076A61K47/34A61P29/00A61P25/00B82Y5/00D01D5/00D01D5/34
CPCA61K9/0092A61K9/0024A61K9/0002A61K31/7076A61K47/34A61P29/00A61P25/00B82Y5/00D01D5/003D01D5/0069D01D5/34
Inventor 熊利泽黄佳李宛蓉张璇
Owner 上海市第四人民医院
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