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Content detection method of antiasthmatic tablets

A detection method, the technology of Anchuan tablet, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of simple detection method and inability to control product quality well, and achieve the effect of quality assurance

Pending Publication Date: 2022-04-08
JIANGSU 707 NATURAL PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The detection methods in the existing quality standards are simple and cannot control product quality well

Method used

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  • Content detection method of antiasthmatic tablets
  • Content detection method of antiasthmatic tablets
  • Content detection method of antiasthmatic tablets

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0026] Experimental Example 1 Study on the Methodology of Hyperin Content Determination

[0027] The content detection method of the present invention is obtained by screening, and the screening process is as follows:

[0028] 1. Selection of chromatographic conditions

[0029] The chromatographic column uses octadecylsilane bonded silica gel as filler, the mobile phase is acetonitrile-0.1% acetic acid solution with a volume ratio of 10:90, and the detection wavelength is 360nm. Under this chromatographic condition, hyperin is well separated from other components in the sample, and the number of theoretical plates should not be less than 5000 based on the peak of the hyperin reference product.

[0030] 2. Preparation of the test solution

[0031] Take 10 tablets of this product, grind them finely, accurately add 50mL of methanol with a volume fraction of 80%, weigh the weight, heat to reflux for 1 hour, let cool, weigh again, and make up the lost weight with methanol with a ...

Embodiment 2

[0059] The content detection method of Anchuan Tablets:

[0060] Choice of detection wavelength:

[0061] The hyperin reference substance solution used in the experiment was used for spectral scanning. The experiment showed that the reference substance solution had maximum absorption at a wavelength of 360nm, and the separation effect was good with less interference. Therefore, the detection wavelength was selected to be 360nm.

[0062] figure 1 It is the ultraviolet absorption spectrum of hyperoside, and the absorbance of hyperoside is the largest at the ultraviolet wavelength of 360nm, so the detection wavelength is 360nm;

[0063] Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel is used as filler, acetonitrile-0.1% acetic acid solution (10:90) is used as mobile phase; detection wavelength is 360nm; theoretical plate number is based on hyperin Peak calculation should not be less than 5000;

[0064] Preparation of the reference subs...

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Abstract

The content detection method comprises the following steps: step 1, preparing a reference substance solution, step 2, preparing a test sample solution, step 3, injecting the reference substance solution and the test sample solution into a high performance liquid chromatograph to obtain a chromatogram, and step 4, calculating the content of hyperoside in a test sample according to the chromatogram. The content of lindley eupatorium lindley in each tablet is not less than 50mg in terms of hyperoside (C21H20O12). The content detection method of the antiasthmatic tablet can objectively, comprehensively and accurately evaluate the quality of the antiasthmatic tablet, and has important significance on guaranteeing the quality of the product while guaranteeing the curative effect of the product.

Description

technical field [0001] The invention belongs to the technical field of quality control methods for traditional Chinese medicine preparations, and in particular relates to a content detection method for Anchuan Tablets. Background technique [0002] Anchuan Tablets produced by Jiangsu 707 Natural Pharmaceutical Co., Ltd. relieve cough and eliminate phlegm, ventilate the lung and relieve asthma. It is used for phlegm invading the lung, lung failure to ventilate, chest tightness, cough, wheezing, excessive phlegm, acute and chronic bronchitis, see above symptomatic. The prescription of the Anchuan Tablets contains: Ye Ma Zhui, Tian Xian Zi, Cicada Slough, Vitex Oil, Clenbuterol Hydrochloride, and Chlorpheniramine Maleate. Reflux extraction 3 times, 2 hours each time, combine the medicinal solution, filter, recover ethanol until the alcohol content of the medicinal solution is 30-40%, let it stand for 24 hours, recover the ethanol from the supernatant to the end, and dilute the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/74
Inventor 耿秋霞
Owner JIANGSU 707 NATURAL PHARMA
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