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Trichosanthes kirilowii Maxim extract with skin whitening effect and application thereof

A Trichosanthes extract and skin whitening technology are applied in medical preparations containing active ingredients, skin care preparations, food ingredients containing natural extracts, etc., to achieve the effect of reducing melanin production, flexible and diverse applications, and a wide range of applications

Pending Publication Date: 2022-03-25
上海小方制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But at present, there is no skin whitening product that uses Chinese herbal extracts as active ingredients

Method used

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  • Trichosanthes kirilowii Maxim extract with skin whitening effect and application thereof
  • Trichosanthes kirilowii Maxim extract with skin whitening effect and application thereof
  • Trichosanthes kirilowii Maxim extract with skin whitening effect and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: the preparation of Trichosanthes quince extract

[0040]Take 2.5kg of the nut part of Gualou decoction slices and mash it; 2.5kg of the peel part of Gualou decoction slices, and mix the two ingredients; add water to extract twice, and feed after boiling; add 10 times the amount of water for the first time, decoct for 60 minutes, and the second Add water 6 times at a time, decoct for 40 minutes; filter, concentrate to the corresponding consistency (1.10-1.12, measured at 60°C); slowly add absolute ethanol, stir while adding, so that the alcohol content reaches 70%, let it stand overnight, After filtration, the filtrate recovered ethanol and concentrated in vacuum below 60°C to a thick paste. Operation process such as figure 1 shown.

Embodiment 2

[0041] Embodiment 2: the preparation of Trichosanthes quince extract

[0042] Take 1 kg of the nut part of Gualou decoction slices and mash it; 1 kg of the peel part of Gualou decoction slices, mix the two ingredients; add water to extract twice, and feed after boiling; add 15 times the amount of water for the first time, decoct for 100 minutes, and add water for the second time 5 times, decocted for 30min, filtered, concentrated to the corresponding consistency (about 1.12-1.16, measured at 60°C); slowly added absolute ethanol, stirring while adding, so that the alcohol content reached 60%, stood overnight, filtered After the ethanol is recovered from the filtrate, it is concentrated in vacuum below 70°C to a thick paste.

Embodiment 3

[0043] Embodiment 3: the preparation of Trichosanthes quince extract

[0044] Take 2kg of the nut part of Gualou decoction slices and mash it; 2kg of the peel part of Gualou decoction slices, mix the two ingredients; add water to extract twice, and feed after boiling; add 12 times the amount of water for the first time, decoct for 80 minutes, and add water for the second time 4 times, decoct for 30 minutes, filter, concentrate to the corresponding consistency (about 1.13-1.15, measured at 60°C); slowly add absolute ethanol, stir while adding, so that the alcohol content reaches 80%, stand overnight, filter After the ethanol is recovered from the filtrate, it is concentrated in vacuum below 60°C to a thick paste.

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PUM

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Abstract

An extraction method of the trichosanthes kirilowii maxim extract comprises the following steps: weighing nutlet parts of trichosanthes kirilowii maxim decoction pieces, mashing the nutlet parts, weighing peel parts and nutlet parts of the trichosanthes kirilowii maxim decoction pieces with the same amount, and mixing the peel parts and the nutlet parts of the trichosanthes kirilowii maxim decoction pieces; adding water to extract twice, combining the two decoctions, standing, and filtering to obtain a liquid medicine; concentrating at the temperature of 10 to 100 DEG C until the thickness of the liquid medicine is 1.00 to 2.00; then adding absolute ethyl alcohol to enable the alcohol content to reach 20-90%; and standing for 6-36 hours, filtering, recovering ethanol from filtrate, and carrying out vacuum concentration at the temperature of 20-90 DEG C to obtain the trichosanthes kirilowii maxim extract with the skin whitening effect. The traditional Chinese medicine composition can generate an effective inhibition effect on tyrosinase, can effectively reduce melanogenesis, and realizes whitening and spot fading effects. The invention further discloses application of the trichosanthes kirilowii maxim extract with the skin whitening effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract, in particular to a Trichosanthes quince extract with skin whitening effect. The present invention also relates to the use of the Trichosanthes quince extract with skin whitening effect. Background technique [0002] With the development of the times and the improvement of people's living standards, people pay more and more attention to skin whitening. Various radiation, air pollution, and exposure to strong ultraviolet rays in daily life will cause skin melanocytes to produce excessive melanin, and then the dendrites of melanocytes will transfer and transport melanin to keratinocytes, and then undergo a series of Transported to the stratum corneum, pigmentation is formed, resulting in darkening of the skin. According to modern scientific research, there are two main ways to prevent skin darkening, that is, skin whitening. The first way is to start from the source of its production and i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/428A61K9/00A61P17/00A61K8/9789A61Q19/02A23L33/105A61K131/00
CPCA61K36/428A61K9/0014A61K9/0053A61P17/00A61K8/9789A61Q19/02A23L33/105A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2800/782A61K2800/92A23V2002/00A23V2200/318A23V2250/21A23V2300/14A23V2300/50
Inventor 张宁邹纯朴王冰方家辰
Owner 上海小方制药股份有限公司
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