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Oil gel and preparation method and use thereof

An oil-gel and oil-phase technology, which can be used in applications, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of accelerating the oxidation of unsaturated fatty acids, and achieve high antioxidant properties, simple components, and simple preparation processes.

Active Publication Date: 2022-05-17
SIRIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in this method, the melting zone temperature of the extruder needs to be as high as 100~200°C, and the high temperature process will accelerate the oxidation of unsaturated fatty acids

Method used

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  • Oil gel and preparation method and use thereof
  • Oil gel and preparation method and use thereof
  • Oil gel and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0049] The method of preparation of the product

[0050] The oleogel of the present invention can be prepared by mixing a structuring agent, such as whey protein denatured particles, with liquid oil to form an oil phase suspension, and then adding water. For whey protein denatured granules, a whey protein suspension with a concentration range of 2-25% can be prepared, and after being fully dissolved by magnetic stirring, the denatured protein granules can be prepared by heating at 75-100°C for 30-100 minutes; after drying, Denatured protein powder. 6~35% whey protein denatured granules can be mixed with liquid oil, such as algae oil rich in Omega-3 polyunsaturated fatty acids, and homogenized to obtain an oil phase suspension of whey protein, and then, can be added to the above suspension Add 4~15% water to the mixture, then homogeneously obtain the oil gel of the present invention. The method may not include the step of heating the liquid oil. Herein, heating may be heatin...

Embodiment 1

[0094] Embodiment 1: Structural characterization of oil composition

[0095] 1. Prepare the oil gel according to the formula in Table 1. Specifically, 18wt% whey protein denatured particles were added to 70wt% algae oil rich in Omega-3 polyunsaturated fatty acids, mixed for 0.5-3h to obtain protein oil phase suspension; then 12wt% purified water was added to In the above oil phase suspension, the oil gel rich in Omega-3 polyunsaturated fatty acids is obtained after homogenizing for 3-30 minutes.

[0096] Table 1: Formulations of Oleogels

[0097]

[0098] Oleogels were microscopically observed (stained) for structural characterization: protein particles were stained with Thioflavin T (Th T) fluorescence during preparation; , Germany) captures the imaging of protein particles or networks with an excitation wavelength of 458 nm.

[0099] figure 2 The results of the formation of osmotic networks by protein particles in oil and fat compositions are shown in . according to...

Embodiment 2

[0103] Example 2: Investigation of the amount of denatured protein particles added

[0104] Evaluation of the rheological properties and peroxide value of the oleogel formulations for the content of denatured particles of whey protein. Specifically, the quality of algae oil and water (70 g and 12 g, respectively) was controlled, the quality of protein denatured particles (in g) was changed, and the rheological properties and peroxide value were determined by the method described above. The results are shown in Table 2.

[0105] Table 2: Effects of different amounts of protein denatured particles added on rheological properties and peroxide value

[0106]

[0107] Unformed: refers to that the prepared composition is in the form of liquid or obviously fluid suspension oil, which cannot be condensed into solid or semi-solid.

[0108] According to Table 2, the oil gel can be prepared when the protein denatured particle content is 6-35%, and the oil gel cannot be formed when the...

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Abstract

Provided are oil gels, their preparation methods and uses. The oil gel contains 60-90wt% liquid oil, 6-35wt% structuring agent and 4-15wt% water, wherein the liquid oil contains unsaturated fatty acid, and the structuring agent is protein denatured particles. As an antioxidant edible oil composition rich in unsaturated fatty acids, the oil gel of the present invention has simple components, does not need to add additional stabilizers, avoids the use of thickeners, emulsifiers and organic reagents, and has antioxidant properties , which is beneficial to the long-term storage of the product. The oil gel of the present invention can be used as an oral pharmaceutical preparation for realizing multiple therapeutic effects, such as regulating blood fat and / or clearing thrombus.

Description

technical field [0001] The invention belongs to the field of functional food, and in particular relates to a functional composition rich in unsaturated fatty acids, which is used as an oral pharmaceutical preparation to improve the physical state of a subject and prevent or treat related diseases or diseases. Background technique [0002] Unsaturated fatty acid is a kind of fatty acid that constitutes body fat and is an indispensable fatty acid for the human body. Unsaturated fatty acids are divided into monounsaturated fatty acids and polyunsaturated fatty acids according to the number of double bonds. As a common animal source of unsaturated fatty acids, fish oil contains unsaturated fatty acids that combine with cholesterol to form esters, and then degrade into bile acids to be excreted, which can significantly reduce blood cholesterol, triglycerides and increase high-density lipoprotein. , can be used for anti-hyperlipidemia. In addition, fish oil also has anti-platele...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A23L33/12A61K8/36A61K8/04A61K8/64A61K8/65A61K8/67A61Q19/08A61K31/202A61K47/42A61P7/02A61P19/06
CPCA23L33/12A23L3/3526A61K8/361A61K8/65A61K8/64A61K8/042A61K8/925A61K8/922A61K8/60A61K8/345A61K8/676A61Q19/08A61K9/06A61K31/202A61K9/0053A61K47/42A61K47/22A61K47/26A61P7/02A61P25/28A61P19/02A61P19/06A61P11/06A61P29/00A61P9/10A61P27/10A23V2002/00A61K2800/522A23V2200/3262A23V2200/322A23V2200/30A23V2250/1882A23V2250/54252
Inventor 方素琼陈文荣王培建
Owner SIRIO PHARMA CO LTD
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