Pressure stabilizing system for accurately preparing ultrathin corneal endothelium graft

Abstract

The invention discloses a pressure stabilizing system for accurately preparing an ultrathin corneal endothelium graft. The system comprises an artificial anterior chamber support for cutting the endothelium graft of an in-vitro cornea, a placing part for placing the in-vitro cornea is arranged on the artificial anterior chamber support, and a pressure supply mechanism and a pressure stabilizing mechanism are connected to the artificial anterior chamber support. The pressure supply mechanism and the pressure stabilizing mechanism are both of an elastic pipeline structure, the pressure supply mechanism is connected with a pressurizing device and provides pressure for the liquid medium in the flow channel so as to support the in-vitro cornea on the placing part, and a movable buckle is arranged on the pipeline structure of the pressure stabilizing mechanism. The movable buckle is in sliding fit with the pipeline structure of the pressure stabilizing mechanism so as to cut off all positions of the pipeline structure. A liquid medium of the artificial anterior chamber support enters the pipeline structure of the pressure stabilizing mechanism, and fluctuation generated by internal pressure caused by cutting is reduced through the elastic pipe wall of the pipeline structure so as to maintain the stability of the form of the in-vitro cornea, so that the required thickness can be accurately cut; and real-time fine adjustment of the pressure during cutting operation is realized through a pressure fine adjustment device, so that the success rate of the ultrathin corneal endothelium graft reaches 96% or above.

Description

technical field [0001] The invention relates to the technical field of corneal endothelial graft preparation, in particular to a pressure stabilization system for accurately preparing ultra-thin corneal endothelial grafts. Background technique [0002] The corneal endothelium maintains the transparency and thickness of the cornea due to the barrier function formed by the tight junctions between the cells and the function of the sodium-potassium pump. , refractive surgery, early penetrating or endothelial keratoplasty, endothelial dystrophy, or certain disease stresses (such as diabetes or glaucoma) will cause a significant decrease in the density of corneal endothelial cells, once the density of corneal endothelial cells is less than 400 ~500 cells / mm 2 When there is a cascade of corneal stromal edema, corneal opacity, bullous keratopathy, and vision loss, that is corneal endothelial decompensation. [0003] At present, corneal endothelial transplantation using automatic l...

AI Technical Summary

Problems solved by technology

During the operation of the MORIA artificial anterior chamber pressurization device, it was found that when the cornea was cut, although the pressure was stable, the liquid in the pressurization device still flowed, indicating that the corneal shape was still unstable during cutting

Moreover, the difference in the preservation state of the isolated cornea and the shape of the cornea itself (including curvature, thickness, flexibility, etc.) will also affect the accuracy of corneal cutting.

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