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Compound preparation for treating cough and preparation method thereof

A compound preparation and tablet technology, applied in the field of medicine, can solve problems such as insufficient curative effect and troublesome application of multiple drugs, and achieve the effect of less types of drugs, convenient taking, and convenient taking

Inactive Publication Date: 2022-02-18
崔光华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the insufficient curative effect of the existing single drug and the troublesome combined application of multiple drugs, the purpose of this application is to provide a compound preparation and preparation method for treating cough

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A compound preparation for treating cough is prepared from the following raw materials in proportion by weight: 4.5 parts of dextromethorphan, 30 parts of guaifenesin and 60 parts of cimetidine. Its preparation method comprises the following steps:

[0024] (1) Take by weighing 13.5g of dextromethorphan bulk drug, 90g of guaifenesin bulk drug ether, and 180g of cimetidine bulk drug, and set aside;

[0025] (2) Select the required auxiliary materials according to the prepared dosage form, and set aside;

[0026] (3) According to the conventional preparation method of pharmacy, it is prepared into tablets, and each tablet contains 15 mg of dextromethorphan, 100 mg of guaifenesin, and 200 mg of cimetidine.

Embodiment 2

[0028] A compound preparation for treating cough is prepared from the following raw materials in proportion by weight: 4 parts of dextromethorphan, 26 parts of guaifenesin, and 53 parts of cimetidine. Its preparation method comprises the following steps:

[0029] (1) Weigh 20g of dextromethorphan bulk drug, 130g of guaifenesin bulk drug, and 265g of cimetidine bulk drug, and set aside;

[0030] (2) Select the required auxiliary materials according to the prepared dosage form, and set aside;

[0031] (3) According to the conventional preparation method of pharmacy, it is prepared into a syrup, so that every 10 ml contains 16 mg of dextromethorphan, 104 mg of guaifenesin, and 212 mg of cimetidine.

[0032] drug efficacy test

[0033] 1. Select the medicines prepared in Examples 1 and 2 to carry out clinical trials.

[0034] According to the design scheme of parallel, randomized and controlled experiments, a control group was strictly set up to observe the clinical curative ef...

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Abstract

The invention provides a compound preparation for treating cough and a preparation method thereof. The compound preparation is prepared from the following raw material medicines, by weight: 3-6 parts of dextromethorphan, 20-40 parts of guaifenesin and 40-80 parts of cimetidine. The compound preparation for treating cough can be obtained by taking corresponding parts of raw material medicines and a proper amount of corresponding auxiliary materials and respectively preparing the raw material medicines into tablets, capsules, syrup, solutions, dry suspensions, granules or other dosage forms according to corresponding preparation methods in pharmaceutics. The compound preparation is prepared from the dextromethorphan, the guaifenesin and the cimetidine, is used for treating cough caused by acute and chronic bronchitis, bronchial asthma and other respiratory system diseases, and can remarkably improve the pharmaceutical curative effect of the dextromethorphan and the guaifenesin and reduce the adverse reaction of the dextromethorphan and the guaifenesin. The compound preparation can be prepared into any dosage form such as tablets, capsules, syrup, solutions, dry suspensions or granules so as to be convenient for patients to take.

Description

technical field [0001] The application relates to the technical field of medicine, in particular to a compound preparation for treating cough and a preparation method thereof. Background technique [0002] Cough is a common symptom of respiratory disease. Caused by inflammation, foreign body, physical or chemical stimulation of the trachea, bronchial mucosa or pleura. Among them, cough caused by acute bronchitis, chronic bronchitis, bronchial asthma and other respiratory diseases is the most common, such as chronic bronchitis, when airway inflammation is severe, symptoms such as cough, expectoration, and dyspnea will occur; acute bronchitis It is an acute inflammation of the bronchial mucosa caused by biological or abiotic pathogenic factors. The main clinical symptoms are cough, sputum, chest tightness, shortness of breath, and fever. [0003] Although there are more and more ways to treat cough caused by acute bronchitis, chronic bronchitis, bronchial asthma and other re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/485A61K31/09A61K31/4164A61P11/14A61P11/10
CPCA61K31/485A61K31/09A61K31/4164A61P11/14A61P11/10A61K2300/00
Inventor 崔光华
Owner 崔光华
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