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Traditional Chinese medicine extract and traditional Chinese medicine preparation capable of promoting skin cell proliferation

A technology for skin cells and traditional Chinese medicine preparations is applied in the fields of traditional Chinese medicine extracts that can promote skin cell proliferation, and traditional Chinese medicine preparations that promote skin cell proliferation, and achieves high safety, promotes human dermal fibroblast proliferation, and has the effects of low toxicity and side effects.

Pending Publication Date: 2022-02-15
上海小方制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are drugs including vitamins and signaling pathway regulators targeting photoaging and inhibiting skin aging, but there is still a big gap in the development of beauty products in the field of modern Chinese medicine

Method used

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  • Traditional Chinese medicine extract and traditional Chinese medicine preparation capable of promoting skin cell proliferation
  • Traditional Chinese medicine extract and traditional Chinese medicine preparation capable of promoting skin cell proliferation
  • Traditional Chinese medicine extract and traditional Chinese medicine preparation capable of promoting skin cell proliferation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The preparation of embodiment 1 Chinese medicine extract:

[0044] Weigh 2.5kg (10 parts) of bitter almonds, 2.5kg (10 parts) of Trichosanthes kernels, 2.5kg (10 parts) of Trichosanthes peel, mash them, add 6 times the amount of water, cook for 120 minutes, add 18 times more water, and cook 20 minutes, filter, measure the density at 20°C, concentrate until its consistency is 1.90, then add absolute ethanol to make the alcohol content reach 50%, let it stand for 24 hours, filter, recover ethanol from the filtrate, and store at 50°C Concentrate under vacuum to a thick paste.

Embodiment 2

[0045] The preparation of embodiment 2 Chinese medicine extracts:

[0046] Weigh 5kg (10 parts) of bitter almonds, 1.25kg (2.5 parts) of Trichosanthes kernels, 1.25kg (2.5 parts) of Trichosanthes peel, mash them, add 10 times of water, decoct for 40 minutes, add 8 times of water, and decoct for 60 Minutes, filter, measure the density at 60°C, concentrate until its consistency is 1.05-1.18, then add absolute ethanol to make the alcohol content reach 80%, let it stand for 24 hours, filter, and recover ethanol from the filtrate, at 60 Concentrate in vacuo at °C to a thick paste.

Embodiment 3

[0047] The preparation of embodiment 3 Chinese medicine extracts:

[0048] Weigh 1.25kg of bitter almonds (5 parts), 2.5kg of Trichosanthes kernels (10 parts), 2.5kg of Trichosanthes peel (10 parts), mash them, add 12 times the amount of water, cook for 70 minutes, add 3 times more water, and cook 70 minutes, filter, measure the density at 30°C, concentrate until its consistency is 1.20, then add absolute ethanol to make the alcohol content reach 30%, let it stand for 6 hours, filter, recover ethanol from the filtrate, and store at 30°C Concentrate under vacuum to a thick paste.

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Abstract

The invention discloses a traditional Chinese medicine extract capable of promoting skin cell proliferation. An extraction method of the traditional Chinese medicine extract comprises the following steps: weighing extraction raw materials and mashing the raw materials; adding water with the amount being 6-18 times of the amount of the medicine materials, conducting decocting for 30-150 minutes, and taking the decoction; adding water which is 3-18 times of the amount of the medicine materials, conducting decocting for 20-100 minutes, and taking the decoction again; combining the two decoctions, conducting standing, and conducting filtering to obtain a liquid medicine; conducting concentrating at the temperature of 10 to 100 DEG C until the thickness of the liquid medicine is 1.00 to 2.00; adding absolute ethyl alcohol to enable the alcohol content to reach 20-90%; and conducting standing for 6-36 hours, conducting filtering, recovering ethanol from the filtrate, and carrying out vacuum concentration at 20-90 DEG C to obtain the traditional Chinese medicine extract capable of promoting skin cell proliferation. The extract disclosed by the invention has a relatively good effect of promoting cell proliferation on human dermal fibroblasts, so that the aging of the human dermal fibroblasts can be inhibited, and the effect of resisting skin aging is realized. The invention further discloses a traditional Chinese medicine preparation capable of promoting skin cell proliferation.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine extract capable of promoting skin cell proliferation. The invention also relates to a traditional Chinese medicine preparation capable of promoting skin cell proliferation. Background technique [0002] With the improvement of living standards, people have higher requirements for the appearance and condition of the skin. Skin aging is an inevitable problem as we age. Skin aging is mainly manifested as increased skin wrinkles, dry and rough skin, sunken and loose skin, which may be caused by physiological and environmental factors. The main environmental factor leading to skin aging is photoaging, for example, the irradiation of light sources such as ultraviolet rays will accelerate the physiological aging of the skin. The thickness of the dermis is a key factor affecting skin aging, and fibroblasts are the main constituent cells of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61K9/00A61P17/18A61P17/00A61K8/9789A61Q19/00A61Q19/08
CPCA61K36/736A61K36/428A61K9/0014A61P17/18A61P17/00A61K8/9789A61Q19/00A61Q19/08A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2800/5922A61K2300/00
Inventor 邹纯朴王冰张宁方家辰
Owner 上海小方制药股份有限公司
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