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Drug-loaded ceramic artificial bone with extremely small curved surface structure and preparation method of drug-loaded ceramic artificial bone

A very small curved surface, artificial bone technology, applied in the medical field, can solve the problems of poor compatibility of artificial bone, side effects of anti-inflammatory drugs, etc., and achieve the effect of improving the success rate of surgery, facilitating proliferation, and reducing pain

Active Publication Date: 2022-02-11
PARTICLE CLOUD BIOTECHNOLOGY (HANGZHOU) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to overcome the above-mentioned shortcomings of the prior art, and provide a drug-loaded ceramic artificial bone with an extremely small curved surface structure and its preparation method to solve the problem of poor compatibility between the artificial bone and the human body in the prior art, and the side effects of anti-inflammatory drugs on the human body The problem

Method used

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  • Drug-loaded ceramic artificial bone with extremely small curved surface structure and preparation method of drug-loaded ceramic artificial bone
  • Drug-loaded ceramic artificial bone with extremely small curved surface structure and preparation method of drug-loaded ceramic artificial bone
  • Drug-loaded ceramic artificial bone with extremely small curved surface structure and preparation method of drug-loaded ceramic artificial bone

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preparation example Construction

[0032] The invention provides a formula and a preparation method of a drug-loaded ceramic artificial bone with an extremely small curved surface structure. The preparation method of the artificial bone includes: providing raw materials, the raw materials including bioactive glass (BG), β-tricalcium phosphate, HA Whiskers, calcium sulfate, fibrinogen (FG), carboxymethylcellulose (CMC), sodium alginate, chondroitin sulfate, autologous red bone marrow. The method of preparation is to combine composite materials with triple periodic minimal surfaces.

[0033] see figure 1 , the preparation method of artificial bone is as follows:

[0034] (1) Preparation of binder: Weigh carboxymethylcellulose (CMC) and dissolve it in sterile water for injection, place it in a temperature-controlled magnetic stirrer at 85°C and stir for 3 hours, 5% to 6% of CMC will bind agent.

[0035] (2) Preparation of sodium alginate solution: Weigh sodium alginate and dissolve it in sterile water for injec...

Embodiment example 1

[0055] (1) Preparation of binder: Weigh 3g of CMC and 47g of sterilized water for injection and pour it into a blue cap bottle to prepare a 6% CMC solution, place it in a temperature-controlled magnetic stirrer at 85°C and stir for 3 hours to prepare into a 6% CMC solution.

[0056] (2) Weigh sodium alginate and dissolve it in sterile water for injection, place it in a water bath at 55°C and stir slowly for 2 hours, and completely dissolve into a 2% homogeneous solution.

[0057] (3) Preparation of printing paste: mix BG and bioceramic β-tricalcium phosphate in a mass ratio of 5:5 to obtain mixture A; then add HA whiskers to mixture A to obtain mixture B, and HA whiskers are added to mixture B The mass fraction in is 5%; then calcium sulfate, fibrin coagulant and chondroitin sulfate are mixed according to the mass fraction ratio of 55%, 5%, and 40% to obtain mixture C; then the above-mentioned obtained mixture C is added to mixture B, and mixed to obtain Mixture D, wherein th...

Embodiment example 2

[0064] (1) Preparation of binder: Weigh 3.5g of CMC and 46.5g of sterile water for injection and pour them into a blue-capped bottle to prepare a 7% CMC solution, and stir in a temperature-controlled magnetic stirrer at 85°C for 3 hours , to make a 6% CMC solution.

[0065] (2) Weigh sodium alginate and dissolve it in sterile water for injection, place it in a water bath at 55°C and stir slowly for 2 hours, and completely dissolve into a 3% homogeneous solution.

[0066] (3) Preparation of printing paste: mix BG and bioceramic β-tricalcium phosphate in a mass ratio of 7:5 to obtain mixture A; then add HA whiskers to mixture A to obtain mixture B, and HA whiskers are added to mixture B The mass fraction in is 4%; then calcium sulfate, fibrinogen and chondroitin sulfate are mixed according to the mass fraction ratio of 60%, 3%, and 37% to obtain mixture C; then the above obtained mixture C is added to mixture B, and mixed to obtain Mixture D, wherein the mass fraction of mixtur...

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Abstract

The invention provides a drug-loaded ceramic artificial bone with an extremely small curved surface structure and a preparation method thereof. According to the method, a carboxymethyl cellulose binder, beta-tricalcium phosphate and chondroitin sulfate are prepared into printing slurry, so the printing slurry has an anti-inflammatory effect, and chondroitin sulfate is a natural substance and has a certain anti-inflammatory effect; therefore, the paste can solve the problems of inflammation of a patient, long curing time and the like, substances of the patient are further added to the surface of the artificial bone, the anti-inflammatory substances and the substances of the patient can prevent inflammation of the patient and promote formation of new bones, and the substances greatly improve the operation success rate and reduce pain of the patient; in addition, the existing artificial bone with the extremely small curved surface structure in the biological field can be accurately prepared.

Description

technical field [0001] The invention belongs to the field of medical technology, and in particular relates to a drug-loaded ceramic artificial bone with an extremely small curved surface structure and a preparation method thereof. Background technique [0002] Human bones play an important role in the human body, such as load bearing, power transmission and cushioning. However, various reasons such as inflammation, injury, tumor, etc. will cause damage to human bone and thus cause joint dysfunction. Bone tissue engineering is currently widely used as a main method for repairing human bones. Traditional bone repair materials have limited strength and toughness, so they cannot provide effective support after being implanted in the human body, and it is easy to cause inflammation during the treatment process and the recovery time of patients is limited. For a long time, both the economy and the body and mind were seriously damaged. In addition, after artificial bone is implan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/42A61L27/54A61L27/58B29C64/30B33Y40/20
CPCA61L27/54A61L27/58A61L27/365A61L27/3604A61L27/425A61L27/427B29C64/30B33Y40/20A61L2430/02
Inventor 曾庆丰张新平
Owner PARTICLE CLOUD BIOTECHNOLOGY (HANGZHOU) CO LTD
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