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Composition containing pinoresinol and cycloartenyl resin 9-glucoside as well as preparation method and application of composition

An olive resinin and rosinol-containing technology, applied in the field of medicine, can solve the problems of not effectively improving drug utilization efficiency, unclear interaction between raw materials, and the curative effect needs to be improved, so as to improve drug storage stability, promote stability, The effect of improving the stability of drug efficacy

Pending Publication Date: 2021-12-17
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Most of the medicaments in the prior art have many types of raw materials. Although they have a certain effect on relieving knee arthritis symptoms, they have not effectively improved the utilization efficiency of the drugs, and the curative effect still needs to be improved. At the same time, the interaction between the raw materials is not clear. During use, side effects are relatively large

Method used

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  • Composition containing pinoresinol and cycloartenyl resin 9-glucoside as well as preparation method and application of composition
  • Composition containing pinoresinol and cycloartenyl resin 9-glucoside as well as preparation method and application of composition

Examples

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Effect test

Embodiment 1

[0037] A composition containing oleoresin 9-glucoside, comprising the following components in parts by weight: 12 parts of oleoresin 9-glucoside, 7 parts of chlorogenic acid, 7 parts of pinoresin, and 4 parts of eucommia alcohol , 2 parts of quercetin.

[0038] The preparation method of the composition containing cyclooleveresin 9-glucoside, comprises the following steps:

[0039] (1) Take distilled water twice the total mass of olivine oleoresin 9-glucoside, chlorogenic acid and pinoresin, and add 0.3wt% of N-dodecyl-N- The mixture of methylglucamide and soybean lecithin is heated to 40°C and then dissolved in olivine 9-glucoside, chlorogenic acid and pinoresin in sequence, and stirred to form solution 1;

[0040] (2) Add tea saponin in distilled water, the addition of tea saponin is 0.3wt% of the total mass of eucommia alcohol and quercetin, then add eucommia alcohol and quercetin to form solution 2;

[0041] (3) The solution 1 and the solution 2 are mixed and stirred to o...

Embodiment 2

[0044] A composition containing oleoresin 9-glucoside, in parts by weight, comprising the following components: 5 parts of oleoresin 9-glucoside, 5 parts of chlorogenic acid, 11 parts of pinoresin, 2 parts of eucommia alcohol , 1 part of quercetin.

[0045] The preparation method of the composition containing cyclooleveresin 9-glucoside, comprises the following steps:

[0046] (1) Get the distilled water of 3 times of the total mass of olivine oleoresin 9-glucoside, chlorogenic acid and pinoresin, add 0.5wt% N-dodecyl-N- The mixture of methylglucamide and soybean lecithin is heated to 30°C and then dissolved in olivine 9-glucoside, chlorogenic acid and pinoresin in sequence, and stirred to form solution 1;

[0047](2) Add tea saponin in distilled water, the addition of tea saponin is 0.1% of the total mass of eucommia alcohol and quercetin, then add eucommia alcohol and quercetin to form solution 2;

[0048] (3) The solution 1 and the solution 2 are mixed and stirred to obta...

Embodiment 3

[0051] A composition containing oleoresin 9-glucoside, comprising the following components in parts by weight: 20 parts of oleoresin 9-glucoside, 10 parts of chlorogenic acid, 11 parts of pinoresin, and 5 parts of eucommia alcohol , 5 parts of quercetin.

[0052] The preparation method of the composition containing cyclooleveresin 9-glucoside, comprises the following steps:

[0053] (1) Get 2-3 times the distilled water of the total mass of olivine oleoresin 9-glucoside, chlorogenic acid and pinoresin, and add 0.1wt% of N-dodecyl- The mixture of N-methylglucamide and soybean lecithin is heated to 45°C and then dissolved in olivine 9-glucoside, chlorogenic acid and pinoresin in sequence, and stirred to form solution 1;

[0054] (2) Add tea saponin in distilled water, the addition of tea saponin is 1% of the total mass of eucommia alcohol and quercetin, then add eucommia alcohol and quercetin to form solution 2;

[0055] (3) The solution 1 and the solution 2 are mixed and stir...

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Abstract

The invention belongs to the technical field of medicines and in particular relates to a composition containing pinoresinol and cycloartenyl resin 9-glucoside as well as a preparation method and application of the composition. The composition is prepared from the following components: cycloartenyl resin 9-glucoside, chlorogenic acid, pinoresinol, eucommiol and quercetin. The composition provided by the invention can be used for effectively improving the effect of treating gonitis; meanwhile, the utilization rate of medicines is relatively high, and the cost is effectively reduced; and meanwhile, side effects of the medicines are reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition containing pinoresin and oleulinin 9-glucoside, a preparation method and application thereof. Background technique [0002] Knee arthritis is a disease based on degenerative pathological changes. Mostly affected by middle-aged and elderly people, the symptoms are mostly red, swollen and painful knees, pain when going up and down stairs, knee soreness and discomfort when sitting up and walking. There will also be patients showing swelling, snapping, effusion, etc. If not treated in time, it will cause joint deformity and disability. In the knee joint, there are often joint diseases such as knee synovitis, ligament injury, meniscus injury, knee joint loose body, popliteal cyst, patellar softening, anserine bursitis, and knee varus / valgus. There are many kinds of medicines for treating knee arthritis. For example, Chinese patent application CN20191054016...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K47/28A61P19/02A61K31/216A61K31/34A61K31/047A61K31/352
CPCA61K31/704A61K31/216A61K31/34A61K31/047A61K31/352A61K47/28A61P19/02A61K2300/00
Inventor 肖军平李小锋毛金娣刘胜张小梅旷春兰张洪军
Owner JIANGXI POZIN PHARMA
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