Thermal response type bornyl steam instant micro-needle eye mask and preparation method and application thereof
A borneol-based, thermally responsive technology, applied in microneedles, needles, pharmaceutical formulations, etc., can solve problems that have not yet been discovered, and achieve the effects of improving bioavailability, accelerating microcirculation, and improving user comfort.
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Embodiment 1
[0051] The thermally responsive borneol-based steam instant microneedle eye patch for relieving eye problems in this embodiment includes the following components by mass percentage:
[0052] Needle base solution: nicotinamide 0.5%, carnosine 0.1%, arbutin 2%, tranexamic acid 0.5%, VC-ethyl ether 0.2%, acetyl hexapeptide-8 2%, palmitoyl pentapeptide-4 1 %, Palmitoyl Tetrapeptide-7 2%, Phytosterol 1%, Hydroxypropyl Tetrahydropyrantriol 0.5%, Fibronectin 1%, Sodium Tocopheryl Phosphate 0.4%, Silk Extract 3%, Natural Right Spiral borneol 0.2%, PEG-40 hydrogenated castor oil 0.8%, Glycyrrhiza glabra root extract 4%, hyaluronic acid 5%, and the balance is deionized water.
[0053] Lining matrix solution: needle body matrix solution 30%, hyaluronic acid 8%, polyvinylpyrrolidone 5%, and the balance is deionized water.
[0054] Intermediate sustained-release layer solution: borneol essential oil 50%, sweet orange essential oil 30%, lavender essential oil 3%, green tea essential oil 5%...
Embodiment 2
[0071] The thermally responsive borneol-based steam instant microneedle eye patch for relieving eye problems in this embodiment includes the following components by mass percentage:
[0072] Needle base solution: nicotinamide 0.8%, carnosine 0.2%, arbutin 1%, tranexamic acid 1%, VC-ethyl ether 0.1%, acetyl hexapeptide-8 3%, palmitoyl pentapeptide-4 2 %, Palmitoyl Tetrapeptide-7 1%, Phytosterol 1.5%, Hydroxypropyl Tetrahydropyrantriol 0.6%, Fibronectin 2%, Sodium Tocopheryl Phosphate 0.5%, Silk Extract 2.5%, Natural Right Spiral borneol 0.5%, PEG-40 hydrogenated castor oil 2%, Glycyrrhiza glabra root extract 2%, hyaluronic acid 6%, and the balance is deionized water.
[0073] Lining matrix solution: needle body matrix solution 30%, hyaluronic acid 5%, polyvinyl alcohol 8%, and the balance is deionized water.
[0074] Intermediate sustained-release layer solution: borneol essential oil 60%, sweet orange essential oil 13%, green tea essential oil 20%, polyglycerol-2 sesquiisoste...
Embodiment 3
[0091] The thermally responsive borneol-based steam instant microneedle eye patch for relieving eye problems in this embodiment includes the following components by mass percentage:
[0092] Needle base solution: niacinamide 1%, carnosine 0.3%, arbutin 0.5%, tranexamic acid 1.5%, VC-ethyl ether 0.5%, acetyl hexapeptide-8 5%, palmitoyl pentapeptide-4 3 %, Palmitoyl Tetrapeptide-7 2%, Phytosterol 0.5%, Hydroxypropyl Tetrahydropyrantriol 0.3%, Fibronectin 3%, Sodium Tocopheryl Phosphate 0.8%, Silk Extract 0.5%, Natural Right Spiral borneol 1%, PEG-40 hydrogenated castor oil 4%, Glycyrrhiza glabra root extract 3%, hyaluronic acid 3%, and the balance is deionized water.
[0093] Lining matrix solution: needle body matrix solution 30%, hyaluronic acid 10%, polyvinyl alcohol 5%, polyvinylpyrrolidone 2%, and the balance is deionized water.
[0094] Intermediate sustained-release layer solution: borneol essential oil 30%, rose essential oil 30%, sweet orange essential oil 24%, green t...
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