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Electrochemical sensor for detecting dopamine in gastric juice as well as preparation method and application of electrochemical sensor

A dopamine and sensor technology, applied in the field of electrochemical sensors and preparations for the detection of dopamine in gastric juice, can solve the problems of high sensor performance and stability requirements, achieve excellent reproducibility and stability, low detection limit, and overcome stability poor sex effect

Inactive Publication Date: 2021-12-10
CIVIL AVIATION UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high performance and stability requirements of the sensor for detection under acidic conditions, there are few reports on electrochemical sensors based on dopamine in gastric juice.

Method used

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  • Electrochemical sensor for detecting dopamine in gastric juice as well as preparation method and application of electrochemical sensor
  • Electrochemical sensor for detecting dopamine in gastric juice as well as preparation method and application of electrochemical sensor
  • Electrochemical sensor for detecting dopamine in gastric juice as well as preparation method and application of electrochemical sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] (1) Nb 2 Preparation of C-MXene

[0045] Add Nb to 40% HF solution 2 AlC powder was reacted for 24 h under 25°C with 700 r / min magnetic stirring to obtain corrosion products; the corrosion products were continuously washed with deionized water until the pH of the supernatant was 7; washed with absolute ethanol for 5 After drying the product in a vacuum oven at 60°C for 12 h, the Nb 2 C matrix material.

[0046] (2) NS-Nb 2 Preparation of C-MXene

[0047] 100 mg Nb prepared in step (1) 2 C powder was ground and mixed with 300 mg thiourea evenly, then put into an atmosphere furnace and heated to 500°C under an argon atmosphere, kept for 3 h, and then cooled to 25°C with the furnace; the prepared material was ground again, and used The deionized water is continuously washed until the pH of the supernatant is 7; the obtained powder is dried to obtain nitrogen and sulfur co-doped Nb 2 C nano powder NS-Nb 2 C-MXene.

[0048] figure 1 Be the NS-Nb that the embodiment...

Embodiment 2

[0057] (1) Nb 2 Preparation of C-MXene

[0058] Add Nb to 50% HF solution 2 AlC powder was reacted at 20°C with 800 r / min magnetic stirring for 20 h to obtain corrosion products; the corrosion products were continuously washed with deionized water until the pH of the supernatant was 6; washed with absolute ethanol for 7 After the second time, the product was dried in a vacuum oven at 60°C for 10 hours to obtain Nb 2 C matrix material.

[0059] (2) NS-Nb 2 Preparation of C-MXene

[0060] 200 mg Nb prepared in step (1) 2 C powder was ground and mixed with 700 mg thiourea evenly, and then put into an atmosphere furnace and heated to 600°C under an argon atmosphere, kept for 4 h, and then cooled to 20°C with the furnace; the prepared material was ground again, and used Wash with deionized water until the pH of the supernatant is 6; dry the obtained powder to obtain NS-Nb 2 C-MXene.

[0061] (3) NS-Nb 2 Preparation of C-MXene / Nafion Modified Electrode

[0062] The NS-Nb p...

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PUM

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Abstract

The invention belongs to the technical field of electrochemical sensors, and discloses an electrochemical sensor for detecting dopamine in gastric juice as well as a preparation method and application thereof. The preparation method disclosed by the invention comprises the following steps: (1) preparing Nb2C-MXene; (2) preparing NS-Nb2C-MXene; (3) preparing an NS-Nb2C-MXene / Nafion modified electrode, and preparing the NS-Nb2C-MXene / Nafion modified electrode, (4) constructing the electrochemical dopamine sensor based on the NS-Nb2C-MXene / Nafion. Through a simple heteroatom doping preparation method, the nitrogen and sulfur co-doped Nb2C / Nafion modified electrode disclosed by the invention has good electrochemical activity, stability and reproducibility, and nitrogen and sulfur co-doping synergistically enhances an electrochemical response signal of a sensor, so rapid and sensitive detection of dopamine in gastric juice under an acidic condition is realized.

Description

technical field [0001] The invention belongs to the technical field of electrochemical sensors, and in particular relates to an electrochemical sensor for detecting dopamine in gastric juice, a preparation method and application thereof. Background technique [0002] Dopamine is the most abundant catecholamine neurotransmitter in the human central nervous system. It plays an important regulatory role in gastrointestinal motility, gastric acid secretion, gastric mucosal blood flow oxygen supply and various gastrointestinal diseases. It is currently involved in gastrointestinal diseases. One of the protective factors of the mucous membrane. Therefore, the quantitative detection of dopamine in biological systems, especially the detection of dopamine in gastric juice under acidic conditions, is of great significance to human health and the diagnosis, treatment and control of diseases. [0003] In recent years, a lot of research has been carried out around the detection methods ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30G01N27/48
CPCG01N27/308G01N27/48
Inventor 陈达石宇晴练美玲
Owner CIVIL AVIATION UNIV OF CHINA
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