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Application of flavonol derivative to preparation of anti-chlamydia infection medicine

A technology for flavonols and chlamydia, which is applied in the field of medicine, can solve the problems of low content of dihydroflavonoids and no biological activity, etc., and achieves good anti-chlamydia proliferation activity, wide application, and good effect of inhibiting proliferation.

Active Publication Date: 2021-12-10
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the content of dihydroflavonoids with complex rearrangements in the B ring is extremely low in nature, and there are no reports on their biological activities at the same time

Method used

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  • Application of flavonol derivative to preparation of anti-chlamydia infection medicine
  • Application of flavonol derivative to preparation of anti-chlamydia infection medicine
  • Application of flavonol derivative to preparation of anti-chlamydia infection medicine

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Experimental program
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Effect test

Embodiment 1

[0023] Embodiment 1, structural formula is the preparation of formula I compound

[0024] The present invention adopts the steps of extraction, purification and the like under conventional conditions under laboratory culture conditions to prepare the compound of the present invention. The plant used therein is fresh pine leaves (Pinusyunnanensis Franch).

[0025] The process of concrete compound is as follows: 1) extract

[0026] Collect fresh pine leaves (5.2kg) of Pine yunnanensis, dry in the shade, crush them, extract with absolute ethanol at room temperature (5L*3), and concentrate the extract to dryness under reduced pressure to obtain about 1071.8g of the transformed residue.

[0027] 2) Reverse-phase silica gel column purification

[0028] Dissolve the resulting residue in an appropriate amount of methanol, add to a chromatographic column equipped with 120 g of reversed-phase silica gel (120 angstroms, 30–50 mesh), and elute with a methanol-water system gradient (30%-...

Embodiment 2

[0035] Embodiment 2: the anti-chlamydia activity of compound I of the present invention

[0036] (1) Experimental materials

[0037] Instruments and reagents: carbon dioxide incubator; microplate reader (Bio-TEKELx800); fluorescent inverted microscope (Olympus IX51); RPM I1640 medium (Gibcol BRL), RNaseA, fetal calf serum, dimethyl sulfoxide (DMSO), pancreatic Protease (Shanghai Bioengineering Co., Ltd.), HeLa / Hep2 cells. The pathogenic strains of Chlamydia used in the test: Chlamydia trachomatis (Ct), Chlamydia pneumoniae (Cpn), and murine variant Chlamydia (Chlamydia muridarum Nigg, MoPn) were purchased from the Institute of Microbiology, Chinese Academy of Medical Sciences.

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Abstract

The invention belongs to the technical field of medicine preparation, and discloses an application of a flavonol derivative to preparation of an anti-chlamydia infection medicine. The flavonol derivative provided by the invention has a relatively good anti-chlamydia proliferation effect on plant growth, can be used for preparing the anti-chlamydia infection medicine, and has relatively good medical application as an active component of the anti-chlamydia infection medicine.

Description

technical field [0001] The invention relates to the field of medicine, and relates to the application of a flavonoid alcohol derivative in the preparation of an anti-chlamydia infection drug, in particular to the application of a dihydroflavonoid alcohol derivative in the preparation of an anti-chlamydia infection drug. Background technique [0002] Chlamydia is a prokaryotic Gram-negative pathogen with a unique biphasic developmental cycle and strict eukaryotic intracellular parasitism, which can infect any animal and cause a variety of diseases. The main pathogenic chlamydia mainly include chlamydia trachomatis, chlamydia pneumoniae and chlamydia psittaci. Genital Chlamydia trachomatis infection is one of the most common sexually transmitted diseases worldwide. According to reports, there are approximately 130 million new infections of genital chlamydia trachomatis each year, which has risen to the top of the list of sexually transmitted diseases. When Chlamydia trachoma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61P31/04A61K36/15C07D311/32C07D311/40A61K127/00
CPCA61K31/353A61P31/04A61K36/15C07D311/32C07D311/40
Inventor 李建林刘迪宋妍王安东杨敏
Owner NANTONG UNIVERSITY
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