Preparation and application of polyelectrolyte-coated drug-loaded Gd2O3@mesoporous silica nanoparticles

A technology of mesoporous silica and nanoparticles, which can be applied in preparations for in vivo experiments, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of reducing the relaxation rate of Gd3+

Inactive Publication Date: 2021-12-03
贺克武
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The introduction of chelate reduced the Gd to a certain extent 3+ Toxicity, but also occupy Gd 3+ most of the water coordination sites, reducing the Gd 3+ relaxation rate

Method used

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  • Preparation and application of polyelectrolyte-coated drug-loaded Gd2O3@mesoporous silica nanoparticles
  • Preparation and application of polyelectrolyte-coated drug-loaded Gd2O3@mesoporous silica nanoparticles
  • Preparation and application of polyelectrolyte-coated drug-loaded Gd2O3@mesoporous silica nanoparticles

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Embodiment Construction

[0048] In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further elaborated below in conjunction with specific embodiments.

[0049] Synthetic Gd 2 o 3 Nanoparticles

[0050] 2.4g GdCl 3 .6H 2 Add O and 40ml DEG into a 50ml reaction kettle, tighten the sealing screw, place on a constant temperature stirring table, 750rpm, 80°C, 60min; open the reaction kettle, take 1mmol / L NaOH 4.5ml into the reaction kettle, mix well, and tighten Reactor lid, 750rpm, 140°C, 60min, then change the reaction conditions to 750rpm, 180°C, 240min, stop the reaction, and cool naturally. The light brown product was transferred into a container, added with 400ml of ultrapure water, mixed well, and stored in a refrigerator at 4°C. Take 10ul sample and drop it on the TEM carbon support film, let it dry naturally, and test it on the TEM machine.

[0051] Synthetic Gd 2 o 3 @MSN

[0052] W...

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Abstract

The invention discloses preparation and application of polyelectrolyte-coated drug-loaded Gd2O3@mesoporous silica nanoparticles, and relates to the technical field of medicinal chemistry. The preparation method comprises the following steps: loading synthesized Gd2O3 nanoparticles on mesoporous walls of MSN by adopting a one-step method, removing a synthesis template CTAB by adopting a calcination method, loading DOX in mesopores of MSN by utilizing an ultrasonic oscillation method, coating the surface of MSN with a pH responsive substance PAH / P (DMA-co-TPAMA) by using an LBL method, connecting folic acid to the outermost layer of the coating material to serve as a targeting agent, and therefore the pH responsive polyelectrolyte-coated drug-loaded Gd2O3@mesoporous silica nanoparticles are prepared and have the cancer cell targeting property, the cancer cell microenvironment response drug controlled release property and the MRI contrast agent enhancement effect, and the purposes of diagnosis and treatment integration, anti-cancer drug tracing, real-time curative effect monitoring and the like are achieved.

Description

Technical field: [0001] The invention relates to the technical field of medicinal chemistry, in particular to a polyelectrolyte-coated drug-loaded Gd 2 o 3 Preparation and application of mesoporous silica nanoparticles. Background technique: [0002] Liver cancer is a common and frequently-occurring disease in my country. Although various methods have been developed for the treatment of liver cancer, such as surgical resection, TACE, radiofrequency ablation, systemic chemotherapy, gene-targeted drug therapy, immunotherapy, radiotherapy, etc. Both morbidity and mortality are increasing year by year. At present, the key factors restricting the curative effect of liver cancer are the difficulty in early detection, early diagnosis and early treatment of tumors. In recent years, there has been extensive attention and in-depth research on the medical application of nanomaterials worldwide, especially the rapid development of targeting agents, tumor internal environment responsiv...

Claims

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Application Information

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IPC IPC(8): A61K49/18A61K49/12A61K47/69A61K49/08A61K47/54A61K31/704A61P35/00C08F8/46C08F8/32C08F220/54C08F220/60
CPCA61K49/1818A61K47/6923A61K31/704A61P35/00A61K47/545A61K47/6935A61K49/08A61K49/126C08F8/46C08F8/32C08F2438/03C08F220/54C08F220/60
Inventor 贺克武余永强沈玉先
Owner 贺克武
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