Application of dry paste powder of Ardisia brevicaulis Diels in preparation of anti-inflammatory and analgesic drugs

An anti-inflammatory, analgesic, and dry ointment technology, which is applied in the direction of anti-inflammatory agents, drug combinations, antipyretics, etc., and can solve problems that have not been reported.

Active Publication Date: 2021-11-30
GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern pharmacological studies have shown that blood party has anti-tumor activity, but there are few reports on other pharmacological activities of blood party, and there is no report at home and abroad on the pharmacological activity of blood party or its extracts on anti-inflammatory and analgesic effects

Method used

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  • Application of dry paste powder of Ardisia brevicaulis Diels in preparation of anti-inflammatory and analgesic drugs
  • Application of dry paste powder of Ardisia brevicaulis Diels in preparation of anti-inflammatory and analgesic drugs
  • Application of dry paste powder of Ardisia brevicaulis Diels in preparation of anti-inflammatory and analgesic drugs

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Application of a Zhuang medicine Xuedang dry ointment powder in the preparation of anti-inflammatory and analgesic drugs, the said Zhuang medicine Xuedang is the purple gold bovine plant nine tube blood ( Ardisia brevicaulis Diels ) of the dried whole plant.

[0022] The extracting method of described Zhuang medicine Xuedanggan ointment powder, comprises the steps:

[0023] (1) Chopped the Zhuang medicine Xuedang medicinal material, added water 10 times the weight of the medicinal material, soaked for 1 hour, heated and boiled for 2 hours, filtered; added 10 times the amount of water to the filter residue, heated and boiled for 1 hour, filtered; added 10 times the filter residue After a certain amount of water was heated and boiled for 1 hour, filtered; the filtrates were combined for 3 times, and concentrated at 90°C to a concentrated medicinal solution with a relative density of 1.05-1.25;

[0024] (2) Let the concentrated medicinal solution cool down to room tempera...

Embodiment 2

[0027] Application of a Zhuang medicine Xuedang dry ointment powder in the preparation of anti-inflammatory and analgesic drugs, the said Zhuang medicine Xuedang is the purple gold bovine plant nine tube blood ( Ardisia brevicaulis Diels ) of the dried whole plant.

[0028] The extracting method of described Zhuang medicine Xuedanggan ointment powder, comprises the steps:

[0029] (1) Chopped the Zhuang medicine Xuedang medicinal material, added water 10 times the weight of the medicinal material, soaked for 1 hour, heated and boiled for 2 hours, filtered; added 10 times the amount of water to the filter residue, heated and boiled for 1 hour, filtered; added 10 times the filter residue After a certain amount of water was heated and boiled for 1 hour, filtered; the filtrates were combined for 3 times, and concentrated at 90°C to a concentrated medicinal solution with a relative density of 1.05-1.25;

[0030] (2) Let the concentrated medicinal solution cool down to room tempera...

Embodiment 3

[0033] Application of a Zhuang medicine Xuedang dry ointment powder in the preparation of anti-inflammatory and analgesic drugs, the said Zhuang medicine Xuedang is the purple gold bovine plant nine tube blood ( Ardisia brevicaulis Diels ) of the dried whole plant.

[0034] The extracting method of described Zhuang medicine Xuedanggan ointment powder, comprises the steps:

[0035] (1) Chopped the Zhuang medicine Xuedang medicinal material, added water 10 times the weight of the medicinal material, soaked for 1 hour, heated and boiled for 2 hours, filtered; added 10 times the amount of water to the filter residue, heated and boiled for 1 hour, filtered; added 10 times the filter residue After a certain amount of water was heated and boiled for 1 hour, filtered; the filtrates were combined for 3 times, and concentrated at 90°C to a concentrated medicinal solution with a relative density of 1.05-1.25;

[0036](2) Let the concentrated medicinal solution cool down to room temperat...

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Abstract

The invention belongs to the technical field of Zhuang medicines of traditional Chinese medicines, and particularly relates to application of dry paste powder of Ardisia brevicaulis Diels in preparation of anti-inflammatory and analgesic drugs. The Ardisia brevicaulis Diels is a whole dry plant of Ardisia brevicaulis Diels, and the dry paste powder of Ardisia brevicaulis Diels is extracted by adopting a water extraction and alcohol precipitation method. The invention discloses the application of the dry paste powder of Ardisia brevicaulis Diels in preparation of the anti-inflammatory and analgesic drugs for the first time. Pharmacological tests show that the dry paste powder of Ardisia brevicaulis Diels can obviously reduce the xylene-induced mouse auricle inflammation swelling degree, obviously reduce the mouse cotton ball granuloma quality, obviously improve the mouse hot plate pain threshold and obviously reduce the acetic acid-induced mouse pain writhing reaction frequency, has obvious anti-inflammatory and analgesic effects, and can be applied to preparation of the anti-inflammatory and analgesic drugs.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine Zhuang medicine, and in particular relates to the application of Zhuang medicine Xuedanggan ointment powder in the preparation of anti-inflammatory and analgesic medicines. Background technique [0002] Inflammation is the body's defense-based response to various inflammatory factors. The clinical features are redness, swelling, heat, and pain. It is the response of inflammatory factors to stimulate living tissues with vascular system to local damage. The pathological process is generally divided into early capillary hyperpermeability, exudation of vascular contents, edema, and late connective tissue hyperplasia and granuloma formation; pain refers to the somatic sensation associated with tissue damage and potential tissue damage. or injury, the injured site releases pain-causing substances such as bradykinin, histamine, serotonin, and prostaglandin, which stimulate the recept...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P29/00
CPCA61K36/185A61P29/00A61K2236/333A61K2236/39A61K2236/53A61K2236/51
Inventor 陈晓军华全东农云开
Owner GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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