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Application of typhagoside in preparation of medicine for treating inflammatory bowel diseases

A technology of inflammatory bowel disease and Typhaloside, which is applied in the application field of traditional Chinese medicine monomer Typhaloside in the preparation of drugs for the treatment of inflammatory bowel disease. reduce the effect of expression

Pending Publication Date: 2021-11-30
GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, some studies have shown that Typhaloside plays a certain role in anti-inflammation, acute myeloid leukemia, animal ventricular remodeling and brain glutamate release, but there is no precedent for Typhaloside in the treatment of IBD

Method used

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  • Application of typhagoside in preparation of medicine for treating inflammatory bowel diseases
  • Application of typhagoside in preparation of medicine for treating inflammatory bowel diseases
  • Application of typhagoside in preparation of medicine for treating inflammatory bowel diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Effect of Typhaloside on Disease Symptoms in Ulcerative Colitis Mice

[0035] Thirty healthy 8-week-old female C57BL / 6J mice with a body weight of about 18-20 g were randomly divided into 3 groups, 10 in each group, namely the control group (PBS group), the model group (DSS group) and the cattail glycoside group In the (TYP+DSS) group, administration was performed after the mice adapted to the SPF environment for 1 week. The control group was administered with PBS and drank normal water; dissolving Typhaloside (TYP) in phosphate buffered saline (PBS), and administered 8-week-old male C57BL / 6J at a dose of 40 mg / kg according to the weight of the mice Mice, DSS group and TYP+DSS group mice were used 2% dextran sodium sulfate (DSS) to establish colitis model. The DSS solution was changed every two days. The experimental animal groups and administration methods are shown in Table 1.

[0036] Table 1 Animal experiment design

[0037]

[0038] After starting ...

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Abstract

The invention creatively provides an application of typhagoside in preparation of a medicine for treating inflammatory bowel diseases. According to the application disclosed by the invention, a DSS-induced C57BL / 6J mouse colitis model is treated by the typhagoside. Inflammation-related parameters such as weight loss, disease activity index and spleen weight of a mouse are improved, histological staining reveals that intestinal inflammation of the mouse is inhibited, and the pathological score is reduced. By further investigating a specific mechanism of anti-inflammatory effect, the result shows that the typhagoside can inhibit activation of an NF-kB pathway in mouse intestinal epithelial cells and reduce expression of inflammatory factors in the mouse intestinal epithelial cells. In conclusion, the Chinese herbal monomer typhagoside can provide a new way for preparing medicines for treating IBD and related diseases thereof in the future.

Description

technical field [0001] The invention belongs to the field of new applications of typtail glycosides, and in particular relates to the application of the traditional Chinese medicine monomer typtail glycosides in the preparation of medicines for treating inflammatory bowel disease. Background technique [0002] IBD is a chronic non-specific intestinal inflammatory disease of unknown etiology, including ulcerative colitis (Ulcerative Colitis, UC) and Crohn's Disease (Crohn's Disease, CD). The most common symptom is diarrhea, accompanied by abdominal cramps, vomiting, blood in the stool, anemia, tiredness, etc. Although my country is a low-incidence area of ​​IBD in the world, due to the westernization of dietary structure and lifestyle in our country, the incidence rate in many areas has a tendency to increase to varying degrees. The occurrence of IBD is a complex process, and its etiology and pathogenesis are still unclear. It is currently considered to be the result of the ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P1/00A61K36/88A61K133/00
CPCA61K31/7048A61P1/00A61K36/88
Inventor 曹海龙王邦茂谢润祥仲威龙谷雨李梦帆杨云蔚孙悦李凌峰
Owner GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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